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Pneumonia remains a leading global cause of morbidity and mortality, particularly in low-resource settings where access to imaging, laboratory testing, and specialist care is limited. Clinical assessment relies on heterogeneous evidence,…

Computer Vision and Pattern Recognition · Computer Science 2026-05-27 Dineth Jayakody , Pasindu Thenahandi , Chameli Dommanige

The therapeutic working alliance is a critical predictor of psychotherapy success. Traditionally, working alliance assessment relies on questionnaires completed by both therapists and patients. In this paper, we present COMPASS, a novel…

Computation and Language · Computer Science 2025-08-12 Baihan Lin , Djallel Bouneffouf , Yulia Landa , Rachel Jespersen , Cheryl Corcoran , Guillermo Cecchi

Network pharmacology (NP) explores pharmacological mechanisms through biological networks. Multi-omics data enable multi-layer network construction under diverse conditions, requiring integration into NP analyses. We developed POINT, a…

Molecular Networks · Quantitative Biology 2025-03-11 Zihao He , Liu Liu , Dongchen Han , Kai Gao , Lei Dong , Dechao Bu , Peipei Huo , Zhihao Wang , Wenxin Deng , Jingjia Liu , Jin-cheng Guo , Yi Zhao , Yang Wu

Computer-aided diagnosis (CAD) systems play a crucial role in analyzing neuroimaging data for neurological and psychiatric disorders. However, small-sample studies suffer from low reproducibility, while large-scale datasets introduce…

Machine Learning · Computer Science 2025-08-12 Xinglin Zhao , Yanwen Wang , Xiaobo Liu , Yanrong Hao , Rui Cao , Xin Wen

Parkinson's disease (PD), the second most common neurodegenerative disorder, is characterized by dopaminergic neuron loss and the accumulation of abnormal synuclein. PD presents both motor and non-motor symptoms that progressively impair…

Machine Learning · Computer Science 2025-04-07 Masahiro Matsumoto , Abu Saleh Musa Miah , Nobuyoshi Asai , Jungpil Shin

We present an application of Physics-Informed Neural Networks to handle MultiPhase-Field simulations of microstructure evolution. It has been showcased that a combination of optimization techniques extended and adapted from the PINNs…

Materials Science · Physics 2024-09-04 Seifallah Elfetni , Reza Darvishi Kamachali

Cerebral Microbleeds (CMBs) are chronic deposits of small blood products in the brain tissues, which have explicit relation to various cerebrovascular diseases depending on their anatomical location, including cognitive decline,…

Image and Video Processing · Electrical Eng. & Systems 2023-06-27 Jun-Ho Kim , Young Noh , Haejoon Lee , Seul Lee , Woo-Ram Kim , Koung Mi Kang , Eung Yeop Kim , Mohammed A. Al-masni , Dong-Hyun Kim

Understanding a medical conversation between a patient and a physician poses a unique natural language understanding challenge since it combines elements of standard open ended conversation with very domain specific elements that require…

Computation and Language · Computer Science 2020-09-21 Anirudh Joshi , Namit Katariya , Xavier Amatriain , Anitha Kannan

In this paper, we explore the possibility to apply machine learning to make diagnostic predictions using discomfort drawings. A discomfort drawing is an intuitive way for patients to express discomfort and pain related symptoms. These…

Machine Learning · Computer Science 2016-12-06 Cheng Zhang , Hedvig Kjellstrom , Bo C. Bertilson

With the advancement of telemedicine, both researchers and medical practitioners are working hand-in-hand to develop various techniques to automate various medical operations, such as diagnosis report generation. In this paper, we first…

Computation and Language · Computer Science 2023-09-28 Abhisek Tiwari , Anisha Saha , Sriparna Saha , Pushpak Bhattacharyya , Minakshi Dhar

Neuroblastoma (NB), a leading cause of childhood cancer mortality, exhibits significant histopathological variability, necessitating precise subtyping for accurate prognosis and treatment. Traditional diagnostic methods rely on subjective…

Computer Vision and Pattern Recognition · Computer Science 2025-03-20 Huangwei Chen , Yifei Chen , Zhenyu Yan , Mingyang Ding , Chenlei Li , Zhu Zhu , Feiwei Qin

We introduce Matched Machine Learning, a framework that combines the flexibility of machine learning black boxes with the interpretability of matching, a longstanding tool in observational causal inference. Interpretability is paramount in…

Methodology · Statistics 2023-04-05 Marco Morucci , Cynthia Rudin , Alexander Volfovsky

Patient pain can be detected highly reliably from facial expressions using a set of facial muscle-based action units (AUs) defined by the Facial Action Coding System (FACS). A key characteristic of facial expression of pain is the…

Machine Learning · Computer Science 2018-02-21 Zhanli Chen , Rashid Ansari , Diana J. Wilkie

More and more people are experiencing pressure from work, life, and education. These pressures often lead to an anxious state of mind, or even the early symptoms of suicidal ideation. With the advancement of artificial intelligence (AI)…

Human-Computer Interaction · Computer Science 2025-03-21 Longdi Xian , Junhao Xu

In the clinical treatment of mood disorders, the complex behavioral symptoms presented by patients and variability of patient response to particular medication classes can create difficulties in providing fast and reliable treatment when…

Machine Learning · Computer Science 2024-02-13 Bradley T. Baker , Mustafa S. Salman , Zening Fu , Armin Iraji , Elizabeth Osuch , Jeremy Bockholt , Vince D. Calhoun

Graph neural networks (GNN) have emerged as a popular tool for modelling functional magnetic resonance imaging (fMRI) datasets. Many recent studies have reported significant improvements in disorder classification performance via more…

Machine Learning · Computer Science 2026-04-27 Yi Hao Chan , Deepank Girish , Sukrit Gupta , Jing Xia , Chockalingam Kasi , Yinan He , Conghao Wang , Jagath C. Rajapakse

Aggregating multi-subject functional magnetic resonance imaging (fMRI) data is indispensable for generating valid and general inferences from patterns distributed across human brains. The disparities in anatomical structures and functional…

Machine Learning · Computer Science 2019-11-20 Weida Li , Mingxia Liu , Fang Chen , Daoqiang Zhang

This paper describes a novel approach to medical diagnosis based on the SP theory of computing and cognition. The main attractions of this approach are: a format for representing diseases that is simple and intuitive; an ability to cope…

Artificial Intelligence · Computer Science 2014-09-30 J. Gerard Wolff

Schizophrenia is a globally prevalent psychiatric disorder that severely impairs daily life. Schizophrenia is caused by dopamine imbalances in the fronto-striatal pathways of the brain, which influences fine motor control in the cerebellum.…

Computer Vision and Pattern Recognition · Computer Science 2024-08-14 Rafael Castro , Ishaan Patel , Tarun Patanjali , Priya Iyer

Understanding pain-related facial behaviors is essential for digital healthcare in terms of effective monitoring, assisted diagnostics, and treatment planning, particularly for patients unable to communicate verbally. Existing data-driven…

Machine Learning · Computer Science 2025-06-18 Zhiyu Wang , Yang Liu , Hatice Gunes