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Decision-makers are faced with the challenge of estimating what is likely to happen when they take an action. For instance, if I choose not to treat this patient, are they likely to die? Practitioners commonly use supervised learning…

Machine Learning · Statistics 2018-02-02 Peter Schulam , Suchi Saria

Chain-of-thought explanations are widely used to inspect the decision process of large language models (LLMs) and to evaluate the trustworthiness of model outputs, making them important for effective collaboration between LLMs and humans.…

Computation and Language · Computer Science 2025-07-16 Pedro Ferreira , Wilker Aziz , Ivan Titov

The use of high-fidelity computational simulations promises to enable high-throughput hypothesis testing and optimisation of cancer therapies. However, increasing realism comes at the cost of increasing computational requirements. This…

Neural and Evolutionary Computing · Computer Science 2022-12-05 Richard J. Preen , Larry Bull , Andrew Adamatzky

Checklists are simple decision aids that are often used to promote safety and reliability in clinical applications. In this paper, we present a method to learn checklists for clinical decision support. We represent predictive checklists as…

Machine Learning · Computer Science 2022-01-19 Haoran Zhang , Quaid Morris , Berk Ustun , Marzyeh Ghassemi

The integration of bioinformatics predictions and experimental validation plays a pivotal role in advancing biological research, from understanding molecular mechanisms to developing therapeutic strategies. Bioinformatics tools and methods…

Regulation, legal liabilities, and societal concerns challenge the adoption of AI in safety and security-critical applications. One of the key concerns is that adversaries can cause harm by manipulating model predictions without being…

Machine Learning · Computer Science 2023-01-31 Jona Klemenc , Holger Trittenbach

The concept of personalised medicine in cancer therapy is becoming increasingly important. There already exist drugs administered specifically for patients with tumours presenting well-defined mutations. However, the field is still in its…

Biomolecules · Quantitative Biology 2024-08-26 Abbi Abdel-Rehim , Oghenejokpeme Orhobor , Gareth Griffiths , Larisa Soldatova , Ross D. King

For obtaining causal inferences that are objective, and therefore have the best chance of revealing scientific truths, carefully designed and executed randomized experiments are generally considered to be the gold standard. Observational…

Applications · Statistics 2008-11-12 Donald B. Rubin

Within the last few years, there has been a move towards using statistical models in conjunction with neural networks with the end goal of being able to better answer the question, "what do our models know?". From this trend, classical…

Machine Learning · Computer Science 2021-12-03 Achintya Gopal

Machine learning-supported decisions, such as ordering diagnostic tests or determining preventive custody, often require converting probabilistic forecasts into binary classifications. We adopt a consequentialist perspective from decision…

Machine Learning · Computer Science 2026-03-11 Gerardo Flores , Abigail Schiff , Alyssa H. Smith , Julia A Fukuyama , Ashia C. Wilson

A world model is an AI system that simulates how an environment evolves under actions, enabling planning through imagined futures rather than reactive perception. Current world models, however, suffer from visual conflation: the mistaken…

Artificial Intelligence · Computer Science 2026-01-23 Zhikang Chen , Tingting Zhu

Over the past decade, the use of machine learning (ML) models in healthcare applications has rapidly increased. Despite high performance, modern ML models do not always capture patterns the end user requires. For example, a model may…

Online experiments such as Randomised Controlled Trials (RCTs) or A/B-tests are the bread and butter of modern platforms on the web. They are conducted continuously to allow platforms to estimate the causal effect of replacing system…

Machine Learning · Computer Science 2023-04-24 Olivier Jeunen

AI systems are often used to make or contribute to important decisions in a growing range of applications, including criminal justice, hiring, and medicine. Since these decisions impact human lives, it is important that the AI systems act…

Artificial Intelligence · Computer Science 2021-03-16 Duncan C McElfresh , Lok Chan , Kenzie Doyle , Walter Sinnott-Armstrong , Vincent Conitzer , Jana Schaich Borg , John P Dickerson

Different research communities have developed various approaches to assess the credibility of predictive models. Each approach usually works well for a specific type of model, and under some epistemic conditions that are normally satisfied…

Quantitative Methods · Quantitative Biology 2019-10-25 Marco Viceconti , Miguel A. Juárez , Cristina Curreli , Marzio Pennisi , Giulia Russo , Francesco Pappalardo

Estimating a causal query from observational data is an essential task in the analysis of biomolecular networks. Estimation takes as input a network topology, a query estimation method, and observational measurements on the network…

Prediction, where observed data is used to quantify uncertainty about a future observation, is a fundamental problem in statistics. Prediction sets with coverage probability guarantees are a common solution, but these do not provide…

Statistics Theory · Mathematics 2022-11-22 Leonardo Cella , Ryan Martin

Systems biology models are useful models of complex biological systems that may require a large amount of experimental data to fit each model's parameters or to approximate a likelihood function. These models range from a few to thousands…

Quantitative Methods · Quantitative Biology 2024-07-12 Vincent D. Zaballa , Elliot E. Hui

Machine learning models are often trained to predict the outcome resulting from a human decision. For example, if a doctor decides to test a patient for disease, will the patient test positive? A challenge is that historical decision-making…

Machine Learning · Computer Science 2024-04-23 Sidhika Balachandar , Nikhil Garg , Emma Pierson

This paper proposes the use of causal modeling to detect and mitigate algorithmic bias. We provide a brief description of causal modeling and a general overview of our approach. We then use the Adult dataset, which is available for download…

Machine Learning · Computer Science 2023-11-10 Wendy Hui , Wai Kwong Lau