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Healthcare requires AI that is predictive, reliable, and data-efficient. However, recent generative models lack physical foundation and temporal reasoning required for clinical decision support. As scaling language models show diminishing…

Machine Learning · Computer Science 2025-11-21 Mohammad Areeb Qazi , Maryam Nadeem , Mohammad Yaqub

When an algorithm provides risk assessments, we typically think of them as helpful inputs to human decisions, such as when risk scores are presented to judges or doctors. However, a decision-maker may react not only to the information…

Machine Learning · Computer Science 2025-11-04 Bryce McLaughlin , Jann Spiess

Current approaches to building general-purpose AI systems tend to produce systems with both beneficial and harmful capabilities. Further progress in AI development could lead to capabilities that pose extreme risks, such as offensive cyber…

We consider decision problems under uncertainty where the options available to a decision maker and the resulting outcome are related through a causal mechanism which is unknown to the decision maker. We ask how a decision maker can learn…

Artificial Intelligence · Computer Science 2018-07-04 M. Gonzalez-Soto , L. E. Sucar , H. J. Escalante

The widespread adoption of algorithmic decision-making systems has brought about the necessity to interpret the reasoning behind these decisions. The majority of these systems are complex black box models, and auxiliary models are often…

Human-Computer Interaction · Computer Science 2022-02-28 Md Naimul Hoque , Klaus Mueller

Conditioning on some set of confounders that causally affect both treatment and outcome variables can be sufficient for eliminating bias introduced by all such confounders when estimating causal effect of the treatment on the outcome from…

Methodology · Statistics 2018-04-24 Priyantha Wijayatunga

There is a growing trend in molecular and synthetic biology of using mechanistic (non machine learning) models to design biomolecular networks. Once designed, these networks need to be validated by experimental results to ensure the…

Quantitative Methods · Quantitative Biology 2020-11-26 Ruby Sedgwick , John Goertz , Molly Stevens , Ruth Misener , Mark van der Wilk

A growing body of work uses the paradigm of algorithmic fairness to frame the development of techniques to anticipate and proactively mitigate the introduction or exacerbation of health inequities that may follow from the use of…

Machine Learning · Statistics 2022-02-07 Stephen R. Pfohl , Yizhe Xu , Agata Foryciarz , Nikolaos Ignatiadis , Julian Genkins , Nigam H. Shah

We consider comparisons of statistical learning algorithms using multiple data sets, via leave-one-in cross-study validation: each of the algorithms is trained on one data set; the resulting model is then validated on each remaining data…

Applications · Statistics 2015-06-02 Lorenzo Trippa , Levi Waldron , Curtis Huttenhower , Giovanni Parmigiani

A characteristic of existing predictive process monitoring techniques is to first construct a predictive model based on past process executions, and then use it to predict the future of new ongoing cases, without the possibility of updating…

Artificial Intelligence · Computer Science 2023-10-26 Chiara Di Francescomarino , Chiara Ghidini , Fabrizio Maria Maggi , Williams Rizzi , Cosimo Damiano Persia

In biomedical studies, researchers are often interested in assessing the association between one or more ordinal explanatory variables and an outcome variable, at the same time adjusting for covariates of any type. The outcome variable may…

Methodology · Statistics 2023-04-17 Kaspar Rufibach

There is significant interest in deploying machine learning algorithms for diagnostic radiology, as modern learning techniques have made it possible to detect abnormalities in medical images within minutes. While machine-assisted diagnoses…

Data Structures and Algorithms · Computer Science 2022-12-21 Woo-Hyung Cho , Shane Henderson , David Shmoys

Black box machine learning models are currently being used for high stakes decision-making throughout society, causing problems throughout healthcare, criminal justice, and in other domains. People have hoped that creating methods for…

Machine Learning · Statistics 2019-09-24 Cynthia Rudin

This paper presents an approach to the evaluation and validation of mass spectrometry data for construction of an `early warning' diagnostic procedure. We describe implementation of a designed experiment and place emphasis on the consistent…

Statistics Theory · Mathematics 2007-06-13 Bart J. A. Mertens , M. E. de Noo , R. A. E. M. Tollenaar , A. M. Deelder

Machine learning has shown much promise in helping improve the quality of medical, legal, and financial decision-making. In these applications, machine learning models must satisfy two important criteria: (i) they must be causal, since the…

Machine Learning · Computer Science 2021-10-12 Carolyn Kim , Osbert Bastani

A key task in ML is to optimize models at various stages, e.g. by choosing hyperparameters or picking a stopping point. A traditional ML approach is to use validation loss, i.e. to apply the training loss function on a validation set to…

Machine Learning · Computer Science 2026-01-23 Charles B. Delahunt , Courosh Mehanian , Daniel E. Shea , Matthew P. Horning

The main aim of decision support systems is to find solutions that satisfy user requirements. Often, this leads to predictability of those solutions, in the sense that having the input data and the model, an adversary or enemy can predict…

Discrete Mathematics · Computer Science 2021-01-18 Daniel Karapetyan , Andrew J. Parkes

Risk Assessment Instruments (RAIs) are widely used to forecast adverse outcomes in domains such as healthcare and criminal justice. RAIs are commonly trained on observational data and are optimized to predict observable outcomes rather than…

Methodology · Statistics 2021-04-06 Alan Mishler , Niccolò Dalmasso

The wide-spread adoption of representation learning technologies in clinical decision making strongly emphasizes the need for characterizing model reliability and enabling rigorous introspection of model behavior. While the former need is…

Machine Learning · Computer Science 2020-05-01 Jayaraman J. Thiagarajan , Prasanna Sattigeri , Deepta Rajan , Bindya Venkatesh

Advances in machine learning have created new opportunities to develop artificial intelligence (AI)-based clinical decision support systems using past clinical data and improve diagnosis decisions in life-threatening illnesses such breast…

Human-Computer Interaction · Computer Science 2024-12-17 Olya Rezaeian , Onur Asan , Alparslan Emrah Bayrak
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