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Neurological injuries predominantly result in loss of functioning of neurons. These neurons may regain function after particular medical therapeutics, such as Chondroitinase ABC (ChABC), that promote axon elongation by manipulating the…

Optimization and Control · Mathematics 2022-04-01 Cenk Demir , Shumon Koga , Miroslav Krstic

In this work, stabilization of an axonal growth in a neuron associated with the dynamics of tubulin concentration is proposed by designing a boundary control. The dynamics are given by a parabolic Partial Differential Equation (PDE) of the…

Optimization and Control · Mathematics 2021-09-30 Cenk Demir , Shumon Koga , Miroslav Krstic

Exploring novel strategies for the regulation of axon growth, we introduce a periodic event-triggered control (PETC) to enhance the practical implementation of the associated PDE backstepping control law. Neurological injuries may impair…

Optimization and Control · Mathematics 2024-05-01 Cenk Demir , Mamadou Diagne , Miroslav Krstic

A transport PDE with a spatial integral and recirculation with constant delay has been a benchmark for neural operator approximations of PDE backstepping controllers. Introducing a spatially-varying delay into the model gives rise to a gain…

Systems and Control · Electrical Eng. & Systems 2025-10-01 Jie Qi , Jiaqi Hu , Jing Zhang , Miroslav Krstic

The recently introduced DeepONet operator-learning framework for PDE control is extended from the results for basic hyperbolic and parabolic PDEs to an advanced hyperbolic class that involves delays on both the state and the system output…

Optimization and Control · Mathematics 2024-06-17 Jie Qi , Jing Zhang , Miroslav Krstic

The information of spiking neural networks (SNNs) are propagated between the adjacent biological neuron by spikes, which provides a computing paradigm with the promise of simulating the human brain. Recent studies have found that the time…

Neural and Evolutionary Computing · Computer Science 2022-05-05 Pengfei Sun , Longwei Zhu , Dick Botteldooren

We present a methodology for stabilization of general nonlinear systems with actuator dynamics governed by general, quasilinear, first-order hyperbolic PDEs. Since for such PDE-ODE cascades the speed of propagation depends on the PDE state…

Optimization and Control · Mathematics 2017-10-23 Nikolaos Bekiaris-Liberis , Miroslav Krstic

Deep neural networks that approximate nonlinear function-to-function mappings, i.e., operators, which are called DeepONet, have been demonstrated in recent articles to be capable of encoding entire PDE control methodologies, such as…

Analysis of PDEs · Mathematics 2023-08-22 Shanshan Wang , Mamadou Diagne , Miroslav Krstić

We present here the details of a backstepping transformation aiming at reformulating the dynamics of a nonlinear systems subject to unknown long input delay in a form which is suitable for Lyapunov stability analysis. The control law…

Dynamical Systems · Mathematics 2013-05-24 Delphine Bresch-Pietri , Miroslav Krstic

In this paper, a delay compensation design method based on PDE backstepping is developed for a two-dimensional reaction-diffusion partial differential equation (PDE) with bilateral input delays. The PDE is defined in a rectangular domain,…

Optimization and Control · Mathematics 2023-07-10 Dandan Guan , Yanmei Chen , Jie Qi , Linglong Du

A backstepping-based compensator design is developed for a system of $2\times2$ first-order linear hyperbolic partial differential equations (PDE) in the presence of an uncertain long input delay at boundary. We introduce a transport PDE to…

Optimization and Control · Mathematics 2023-07-24 Jing Zhang , Jie Qi

We develop a delay-adaptive controller for a class of first-order hyperbolic partial integro-differential equations (PIDEs) with an unknown input delay. By employing a transport PDE to represent delayed actuator states, the system is…

Analysis of PDEs · Mathematics 2023-07-11 Shanshan Wang , Jie Qi , Miroslav Krstic

The effect of intrinsic channel noise is investigated for the dynamic response of a neuronal cell with a delayed feedback loop. The loop is based on the so-called autapse phenomenon in which dendrites establish not only connections to…

Biological Physics · Physics 2014-12-22 Yunyun Li , Gerhard Schmid , Peter Hanggi , Lutz Schimansky-Geier

We consider the effect of distributed delays in neural feedback systems. The avian optic tectum is reciprocally connected with the nucleus isthmi. Extracellular stimulation combined with intracellular recordings reveal a range of signal…

Biological Physics · Physics 2007-12-04 Ulrike Meyer , Jing Shao , Saurish Chakrabarty , Sebastian F. Brandt , Harald Luksch , Ralf Wessel

We introduce a dynamic event-triggering mechanism for regulating the axonal growth of a neuron. We apply boundary actuation at the soma (the part of a neuron that contains the nucleus) and regulate the dynamics of tubulin concentration and…

Optimization and Control · Mathematics 2024-03-19 Cenk Demir , Shumon Koga , Miroslav Krstic

Neuronal damage, in the form of both brain and spinal cord injuries, is one of the major causes of disability and death in young adults worldwide. One way to assess the direct damage occurring after a mechanical insult is the simulation of…

Neural and Evolutionary Computing · Computer Science 2024-09-20 Antonio LaTorre , Man Ting Kwong , Julián A. García-Grajales , Riyi Shi , Antoine Jérusalem , José-María Peña

Control of distributed parameter systems affected by delays is a challenging task, particularly when the delays depend on spatial variables. The idea of integrating analytical control theory with learning-based control within a unified…

Artificial Intelligence · Computer Science 2025-01-31 Jiaqi Hu , Jie Qi , Jing Zhang

This paper introduces a novel approach to PDE boundary control design using neural operators to alleviate stop-and-go instabilities in congested traffic flow. Our framework leverages neural operators to design control strategies for traffic…

Machine Learning · Computer Science 2023-12-19 Yihuai Zhang , Ruiguo Zhong , Huan Yu

To stabilize PDEs, feedback controllers require gain kernel functions, which are themselves governed by PDEs. Furthermore, these gain-kernel PDEs depend on the PDE plants' functional coefficients. The functional coefficients in PDE plants…

Systems and Control · Electrical Eng. & Systems 2024-01-17 Maxence Lamarque , Luke Bhan , Yuanyuan Shi , Miroslav Krstic

Despite significant advances in understanding neuronal development, a fully quantitative framework that integrates intracellular mechanisms with environmental cues during axonal growth remains incomplete. Here, we present a unified…

Neurons and Cognition · Quantitative Biology 2025-05-26 Kyle Cheng , Udathari Kumarasinghe , Cristian Staii
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