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In artificial neural networks trained with gradient descent, the weights used for processing stimuli are also used during backward passes to calculate gradients. For the real brain to approximate gradients, gradient information would have…

Neurons and Cognition · Quantitative Biology 2020-02-04 Jordan Guerguiev , Konrad P. Kording , Blake A. Richards

Training transmission delays in spiking neural networks (SNNs) has been shown to substantially improve their performance on complex temporal tasks. In this work, we show that learning either axonal or dendritic delays enables deep…

Neural and Evolutionary Computing · Computer Science 2026-02-11 Younes Bouhadjar , Emre Neftci

We establish that stabilization of a class of linear, hyperbolic partial differential equations (PDEs) with a large (nevertheless finite) number of components, can be achieved via employment of a backstepping-based control law, which is…

Optimization and Control · Mathematics 2024-11-05 Jukka-Pekka Humaloja , Nikolaos Bekiaris-Liberis

Deep neural network approximation of nonlinear operators, commonly referred to as DeepONet, has proven capable of approximating PDE backstepping designs in which a single Goursat-form PDE governs a single feedback gain function. In boundary…

Optimization and Control · Mathematics 2024-07-04 Shanshan Wang , Mamadou Diagne , Miroslav Krstić

The pancreatic innervation undergoes dynamic remodeling during the development of pancreatic ductal adenocarcinoma (PDAC). Denervation experiments have shown that different types of axons can exert either pro- or anti-tumor effects, but…

Analysis of PDEs · Mathematics 2024-04-04 Marie-Jose Chaaya , Sophie Chauvet , Florence Hubert , Fanny Mann , Mathieu Mezache , Pierre Pudlo

Time--delayed feedback is exploited for controlling noise--induced motion in coherence resonance oscillators. Namely, under the proper choice of time delay, one can either increase or decrease the regularity of motion. It is shown that in…

Statistical Mechanics · Physics 2009-11-10 N. B. Janson , A. G. Balanov , E. Schoell

The nervous system is today recognized to play an important role in the development of cancer. Indeed, neurons extend long processes (axons) that grow and infiltrate tumors in order to regulate the progression of the disease in a positive…

Dynamical Systems · Mathematics 2022-05-25 Sophie Chauvet , Florence Hubert , Fanny Mann , Mathieu Mezache

The plasticity property of biological neural networks allows them to perform learning and optimize their behavior by changing their configuration. Inspired by biology, plasticity can be modeled in artificial neural networks by using Hebbian…

Neural and Evolutionary Computing · Computer Science 2020-12-21 Anil Yaman , Giovanni Iacca , Decebal Constantin Mocanu , George Fletcher , Mykola Pechenizkiy

This work concerns efficient and reliable numerical simulations of the dynamic behaviour of a moving-boundary model for tubulin-driven axonal growth. The model is nonlinear and consists of a coupled set of a partial differential equation…

Cell Behavior · Quantitative Biology 2016-08-03 Stefan Diehl , Erik Henningsson , Anders Heyden

This paper addresses boundary prescribed-time stabilization of a one-dimensional heat equation with spatially and temporally varying coefficients. In contrast to asymptotic or exponential stabilization, prescribed-time stabilization ensures…

Optimization and Control · Mathematics 2026-02-27 Kaijing Lyu , Umberto Biccari , Jun-Min Wang

Backpropagation (BP) has been pivotal in advancing machine learning and remains essential in computational applications and comparative studies of biological and artificial neural networks. Despite its widespread use, the implementation of…

Neurons and Cognition · Quantitative Biology 2025-04-15 Xinhao Fan , Shreesh P Mysore

This paper presents a backstepping solution for the output feedback control of general linear heterodirectional hyperbolic PDE-ODE systems with spatially-varying coefficients. Thereby, the coupling in the PDE is in-domain and at the…

Optimization and Control · Mathematics 2017-11-03 Joachim Deutscher , Nicole Gehring , Richard Kern

To stabilize PDE models, control laws require space-dependent functional gains mapped by nonlinear operators from the PDE functional coefficients. When a PDE is nonlinear and its "pseudo-coefficient" functions are state-dependent, a…

Systems and Control · Electrical Eng. & Systems 2024-01-08 Maxence Lamarque , Luke Bhan , Rafael Vazquez , Miroslav Krstic

A neural networks (NN) compensator is designed for systems with multi-segment piecewise-linear nonlinearities. The compensator uses the back stepping technique with NN for inverting the multi-segment piecewise-linear nonlinearities in the…

Systems and Control · Electrical Eng. & Systems 2021-10-04 Jun Oh Jang

We propose a novel {\it Equilibrated Recurrent Neural Network} (ERNN) to combat the issues of inaccuracy and instability in conventional RNNs. Drawing upon the concept of autapse in neuroscience, we propose augmenting an RNN with a…

Machine Learning · Computer Science 2019-03-05 Ziming Zhang , Anil Kag , Alan Sullivan , Venkatesh Saligrama

This paper is concerned with the output feedback boundary stabilization of general 1-D reaction diffusion PDEs in the presence of an arbitrarily large input delay. We consider the cases of Dirichlet/Neumann/Robin boundary conditions for the…

Optimization and Control · Mathematics 2022-07-13 Hugo Lhachemi , Christophe Prieur

This paper proposes a backstepping boundary control design for robust stabilization of linear first-order coupled hyperbolic partial differential equations (PDEs) with Markov-jumping parameters. The PDE system consists of 4 X 4 coupled…

Optimization and Control · Mathematics 2023-12-29 Yihuai Zhang , Jean Auriol , Huan Yu

This is the first part of four series papers, aiming at the problem of actuator dynamics compensation for linear systems. We consider the stabilization of a type of cascade abstract linear systems which model the actuator dynamics…

Systems and Control · Electrical Eng. & Systems 2020-08-27 Hongyinping Feng , Xiao-Hui Wu , Bao-Zhu Guo

Neurons are connected to other neurons by axons and dendrites that conduct signals with finite velocities, resulting in delays between the firing of a neuron and the arrival of the resultant impulse at other neurons. Since delays greatly…

Neurons and Cognition · Quantitative Biology 2021-08-25 Akke Mats Houben

Working memory requires the brain to maintain information from the recent past to guide ongoing behavior. Neurons can contribute to this capacity by slowly integrating their inputs over time, creating persistent activity that outlasts the…

Neurons and Cognition · Quantitative Biology 2025-11-20 Nicoas Zucchet , Qianqian Feng , Axel Laborieux , Friedemann Zenke , Walter Senn , João Sacramento