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Here we analyze the topology of the network formed by the minima and transition states on the potential energy landscape of small clusters. We find that this network has both a small-world and scale-free character. In contrast to other…

Condensed Matter · Physics 2007-05-23 Jonathan P. K. Doye

Many biological, chemical, and physical systems are underpinned by stochastic transitions between equilibrium states in a potential energy. Here, we consider such transitions in a minimal model with two possible competing pathways, both…

Statistical Mechanics · Physics 2025-12-17 Gulzar Ahmad , Sergey Saveliev , Steven P Fitzgerald , Marco G Mazza , Andrew J Archer

Functional networks provide a topological description of activity patterns in the brain, as they stem from the propagation of neural activity on the underlying anatomical or structural network of synaptic connections. This latter is well…

Disordered Systems and Neural Networks · Physics 2021-02-11 Ali Safari , Paolo Moretti , Ibai Diez , Jesus M. Cortes , Miguel Ángel Muñoz

Many problems in physics, material sciences, chemistry and biology can be abstractly formulated as a system that navigates over a complex energy landscape of high or infinite dimensions. Well-known examples include phase transitions of…

Numerical Analysis · Mathematics 2025-10-20 Weinan E , Weiqing Ren , Eric Vanden-Eijnden

How systems transit between different stable states under external perturbation is an important practical issue. We discuss here how a recently-developed energy optimization method for identifying the minimal disturbance necessary to reach…

Pattern Formation and Solitons · Physics 2018-05-02 Daniel Lecoanet , Rich R. Kerswell

Recent progress in diverse intelligence has shown simple learning capacities below the organism level - single cells and even molecular networks. However, there are still many knowledge gaps around learning capacity above the organism…

Populations and Evolution · Quantitative Biology 2026-05-29 Adrita Samanta , Hananel Hazan , Michael Levin

Predicting how the brain can be driven to specific states by means of internal or external control requires a fundamental understanding of the relationship between neural connectivity and activity. Network control theory is a powerful tool…

Neurons and Cognition · Quantitative Biology 2019-08-12 Teresa M. Karrer , Jason Z. Kim , Jennifer Stiso , Ari E. Kahn , Fabio Pasqualetti , Ute Habel , Danielle S. Bassett

Energy landscapes provide a valuable means for studying the folding dynamics of short RNA molecules in detail by modeling all possible structures and their transitions. Higher abstraction levels based on a macro-state decomposition of the…

Biomolecules · Quantitative Biology 2014-09-09 Martin Mann , Marcel Kucharik , Christoph Flamm , Michael T. Wolfinger

We investigate a network model in which a single random walker combines local diffusion with preferential resetting to previously visited nodes. Each arrival deposits one unit of stress on the target node, and threshold crossings trigger…

Statistical Mechanics · Physics 2026-04-14 Mohammad Jafari

We introduce a novel model for updating perceptual beliefs about the environment by extending the concept of Allostasis to the control of internal representations. Allostasis is a fundamental regulatory mechanism observed in animal…

Neurons and Cognition · Quantitative Biology 2025-03-21 Aung Htet , Alejandro Rodriguez Jimenez , Sarah Hamburg , Alessandro Di Nuovo

It has previously been shown that the network of connected minima on a potential energy landscape is scale-free, and that this reflects a power-law distribution for the areas of the basins of attraction surrounding the minima. Here, we set…

Statistical Mechanics · Physics 2007-09-19 Claire P. Massen , Jonathan P. K. Doye

Dynamical brain state transitions are critical for flexible working memory but the network mechanisms are incompletely understood. Here, we show that working memory entails brainwide switching between activity states. The stability of…

A neural correlate of parametric working memory is a stimulus specific rise in neuron firing rate that persists long after the stimulus is removed. Network models with local excitation and broad inhibition support persistent neural…

Neurons and Cognition · Quantitative Biology 2013-10-15 Zachary P. Kilpatrick , Bard Ermentrout , Brent Doiron

We address the problem of identifying functional interactions among stochastic neurons with variable-length memory from their spiking activity. The neuronal network is modeled by a stochastic system of interacting point processes with…

Applications · Statistics 2025-07-01 Ricardo F. Ferreira , Matheus E. Pacola , Vitor G. Schiavone , Rodrigo F. O. Pena

This paper proposes networked dynamics to solve resource allocation problems over time-varying multi-agent networks. The state of each agent represents the amount of used resources (or produced utilities) while the total amount of resources…

Systems and Control · Electrical Eng. & Systems 2022-07-26 Mohammadreza Doostmohammadian , Alireza Aghasi , Mohammad Pirani , Ehsan Nekouei , Usman A. Khan , Themistoklis Charalambous

As data-driven methods are deployed in real-world settings, the processes that generate the observed data will often react to the decisions of the learner. For example, a data source may have some incentive for the algorithm to provide a…

Machine Learning · Computer Science 2023-04-26 Roy Dong , Heling Zhang , Lillian J. Ratliff

Recent developments in network neuroscience have highlighted the importance of developing techniques for analyzing and modeling brain networks. A particularly powerful approach for studying complex neural systems is to formulate generative…

Neurons and Cognition · Quantitative Biology 2022-09-09 Viplove Arora , Enrico Amico , Joaquín Goñi , Mario Ventresca

We study data-driven learning of robust stochastic control for infinite-horizon systems with potentially continuous state and action spaces. In many managerial settings--supply chains, finance, manufacturing, services, and dynamic…

Machine Learning · Statistics 2025-11-18 Shengbo Wang , Jason Meng , Nian Si , Jose Blanchet , Zhengyuan Zhou

Deep neural networks are workhorse models in machine learning with multiple layers of non-linear functions composed in series. Their loss function is highly non-convex, yet empirically even gradient descent minimisation is sufficient to…

Disordered Systems and Neural Networks · Physics 2020-03-18 Simon Becker , Yao Zhang , Alpha A. Lee

Qualitatively, some real networks in the brain could be characterized as 'small worlds', in the sense that the structure of their connections is intermediate between the extremes of an orderly geometric arrangement and of a…

Neurons and Cognition · Quantitative Biology 2007-05-23 A. Anishchenko , E. Bienenstock , A. Treves
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