Brain state stability during working memory is explained by network control theory, modulated by dopamine D1/D2 receptor function, and diminished in schizophrenia
Neurons and Cognition
2019-06-25 v1 Biological Physics
Abstract
Dynamical brain state transitions are critical for flexible working memory but the network mechanisms are incompletely understood. Here, we show that working memory entails brainwide switching between activity states. The stability of states relates to dopamine D1 receptor gene expression while state transitions are influenced by D2 receptor expression and pharmacological modulation. Schizophrenia patients show altered network control properties, including a more diverse energy landscape and decreased stability of working memory representations.
Keywords
Cite
@article{arxiv.1906.09290,
title = {Brain state stability during working memory is explained by network control theory, modulated by dopamine D1/D2 receptor function, and diminished in schizophrenia},
author = {Urs Braun and Anais Harneit and Giulio Pergola and Tommaso Menara and Axel Schaefer and Richard F. Betzel and Zhenxiang Zang and Janina I. Schweiger and Kristina Schwarz and Junfang Chen and Giuseppe Blasi and Alessandro Bertolino and Daniel Durstewitz and Fabio Pasqualetti and Emanuel Schwarz and Andreas Meyer-Lindenberg and Danielle S. Bassett and Heike Tost},
journal= {arXiv preprint arXiv:1906.09290},
year = {2019}
}