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Energy landscapes play a crucial role in shaping dynamics of many real-world complex systems. System evolution is often modeled as particles moving on a landscape under the combined effect of energy-driven drift and noise-induced diffusion,…

Computational Engineering, Finance, and Science · Computer Science 2025-03-04 Ruikun Li , Huandong Wang , Qingmin Liao , Yong Li

The interplay between structure and function is crucial in determining some emerging properties of many natural systems. Here we use an adaptive neural network model inspired in observations of synaptic pruning that couples activity and…

Physics and Society · Physics 2019-04-26 Ana P. Millán , J. J. Torres , S. Johnson , J. Marro

Large-scale white matter pathways crisscrossing the cortex create a complex pattern of connectivity that underlies human cognitive function. Generative mechanisms for this architecture have been difficult to identify in part because little…

Neurons and Cognition · Quantitative Biology 2015-06-16 Florian Klimm , Danielle S. Bassett , Jean M. Carlson , Peter J. Mucha

Deep neural networks exhibit a fascinating spectrum of phenomena ranging from predictable scaling laws to the unpredictable emergence of new capabilities as a function of training time, dataset size and network size. Analysis of these…

Machine Learning · Computer Science 2023-07-20 Shreyas Gokhale

The mammalian brain could contain dense and sparse network connectivity structures, including both excitatory and inhibitory neurons, but is without any clearly defined output layer. The neurons have time constants, which mean that the…

Neurons and Cognition · Quantitative Biology 2021-06-04 Udaya B. Rongala , Henrik Jörntell

Cognitive function is driven by dynamic interactions between large-scale neural circuits or networks, enabling behavior. Fundamental principles constraining these dynamic network processes have remained elusive. Here we use network control…

Neurons and Cognition · Quantitative Biology 2015-10-28 Shi Gu , Fabio Pasqualetti , Matthew Cieslak , Scott T. Grafton , Danielle S. Bassett

Dimensionality reduction, a form of compression, can simplify representations of information to increase efficiency and reveal general patterns. Yet, this simplification also forfeits information, thereby reducing representational capacity.…

Free energy landscapes encode the kinetics, intermediates, and transition states that govern molecular processes and are thus a key target of single biomolecule research. Typical approaches to deriving optimal, error-minimizing,…

Biological Physics · Physics 2025-11-25 Oliver Cheng , Zosia Adamska , Michael P. Brenner , Megan C. Engel

We present a simple model system with four hard disks moving in a circular region for which free energy landscapes can be directly calculated and visualized in two and three dimensions. We construct several energy landscapes for our system…

Disordered Systems and Neural Networks · Physics 2021-04-06 Eric R. Weeks , Keely Criddle

We compute the distribution of triplets of stationary points in the energy landscape of the spherical p-spin model, by evaluating the quenched three-point complexity by means of the Kac-Rice formalism. We show the occurrence of transitions…

Disordered Systems and Neural Networks · Physics 2025-03-12 Alessandro Pacco , Alberto Rosso , Valentina Ros

Neural population activity in cortical and hippocampal circuits can be flexibly reorganized by context, suggesting that cognition relies on dynamic manifolds rather than static representations. However, how such dynamic organization can be…

Machine Learning · Computer Science 2026-03-04 Chong Li , Taiping Zeng , Xiangyang Xue , Jianfeng Feng

Working memory - the ability to remember recent events as they recede continuously into the past - requires the ability to represent any stimulus at any time delay. This property requires neurons coding working memory to show mixed…

Neurons and Cognition · Quantitative Biology 2025-08-12 Aakash Sarkar , Chenyu Wang , Shangfu Zuo , Marc W. Howard

We propose a dynamical neural network model with a hierarchical and modular structure. The network architecture can be derived by minimizing an energy function that is originally designed based on two kinds of neurons with quite different…

Neurons and Cognition · Quantitative Biology 2026-04-14 Kazuyoshi Tsutsumi , Ernst Niebur

The phase transition in the number partitioning problem (NPP), i.e., the transition from a region in the space of control parameters in which almost all instances have many solutions to a region in which almost all instances have no…

Condensed Matter · Physics 2016-08-16 Peter F. Stadler , Wim Hordijk , José F. Fontanari

Well characterized sequences of dynamical states play an important role for motor control and associative neural computation in the brain. Autonomous dynamics involving sequences of transiently stable states have been termed associative…

Adaptation and Self-Organizing Systems · Physics 2013-07-15 Mathias Linkerhand , Claudius Gros

An analysis of the network defined by the potential energy minima of multi-atomic systems and their connectivity via reaction pathways that go through transition states allows to understand important characteristics like thermodynamic,…

Materials Science · Physics 2016-08-03 Bastian Schaefer , Stefan Goedecker

Quantifying stochastic processes is essential to understand many natural phenomena, particularly in biology, including cell-fate decision in developmental processes as well as genesis and progression of cancers. While various attempts have…

Statistical Mechanics · Physics 2017-06-28 Ying Tang , Ruoshi Yuan , Gaowei Wang , Xiaomei Zhu , Ping Ao

Semantic memory is the subsystem of human memory that stores knowledge of concepts or meanings, as opposed to life specific experiences. The organization of concepts within semantic memory can be understood as a semantic network, where the…

Continuous "bump" attractors are an established model of cortical working memory for continuous variables and can be implemented using various neuron and network models. Here, we develop a generalizable approach for the approximation of…

Neurons and Cognition · Quantitative Biology 2017-11-23 Alexander Seeholzer , Moritz Deger , Wulfram Gerstner

Demystifying effective connectivity among neuronal populations has become the trend to understand the brain mechanisms of Parkinson's disease, schizophrenia, mild traumatic brain injury, and many other unlisted neurological diseases.…

Quantitative Methods · Quantitative Biology 2019-09-27 Po-Ya Hsu