Related papers: The molecular memory code and synaptic plasticity:…
Memory is often defined as the mental capacity of retaining information about facts, events, procedures and more generally about any type of previous experience. Memories are remembered as long as they influence our thoughts, feelings, and…
The ability to form memories is a basic feature of learning and accumulating knowledge. But where is memory information stored in the brain? Within the scientific research community, it is generally believed that memory information is…
Memories are stored, retained, and recollected through complex, coupled processes operating on multiple timescales. To understand the computational principles behind these intricate networks of interactions we construct a broad class of…
Memory is a complex phenomenon that involves several distinct mechanisms. These mechanisms operate at different spatial and temporal levels. This chapter focuses on the theoretical framework and the mathematical models that have been…
Memory information in the brain is commonly believed to be stored in the synapse. However, a recent groundbreaking electrophysiology research has raised the possibility that memory information may actually be stored inside the neuron…
What is the physiological basis of long-term memory? The prevailing view in neuroscience attributes changes in synaptic efficacy to memory acquisition. This view implies that stable memories correspond to stable connectivity patterns.…
Within the scientific research community, memory information in the brain is commonly believed to be stored in the synapse - a hypothesis famously attributed to psychologist Donald Hebb. However, there is a growing minority who postulate…
The main problem about replacing LTP as a memory mechanism has been to find other highly abstract, easily understandable principles for induced plasticity. In this paper we attempt to lay out such a basic mechanism, namely intrinsic…
We present an account of neuroplasticity with respect to cell-internal processing pathways in relation to membrane and synaptic plasticity. We think traditional synapse-centric, weight-based models of memorization are not sufficient or…
Synaptic plasticity is the capacity of a preexisting connection between two neurons to change in strength as a function of neural activity. Because synaptic plasticity is the major candidate mechanism for learning and memory, the…
We have recognized that 2D codes, i.e., a group of strongly connected neurosomes that can be simultaneously excited, are the basic data carriers for memory in a brain. An echoing mechanism between two neighboring layers of neurosomes is…
We first review traditional approaches to memory storage and formation, drawing on the literature of quantitative neuroscience as well as statistical physics. These have generally focused on the fast dynamics of neurons; however, there is…
Competitive dynamics are thought to occur in many processes of learning involving synaptic plasticity. Here we show, in a game theory-inspired model of synaptic interactions, that the competition between synapses in their weak and strong…
The standard model of memory consolidation foresees that memories are initially recorded in the hippocampus, while features that capture higher-level generalisations of data are created in the cortex, where they are stored for a possibly…
In the mammalian brain newly acquired memories depend on the hippocampus for maintenance and recall, but over time these functions are taken over by the neocortex through a process called systems consolidation. However, reactivation of a…
In the mammalian brain, newly acquired memories depend on the hippocampus for maintenance and recall, but over time the neocortex takes over these functions, rendering memories hippocampus-independent. The process responsible for this…
Learning and memory relies on synapses changing their strengths in response to neural activity. However there is a substantial gap between the timescales of neural electrical dynamics (1-100 ms) and organism behaviour during learning…
Humans have long been fascinated by how memories are formed, how they can be damaged or lost, or still seem vibrant after many years. Thus the search for the locus and organization of memory has had a long history, in which the notion that…
Memories are stored, at least partly, as patterns of strong synapses. Given molecular turnover, how can synapses maintain strong for the years that memories can persist? Some models postulate that biochemical bistability maintains strong…
General results from statistical learning theory suggest to understand not only brain computations, but also brain plasticity as probabilistic inference. But a model for that has been missing. We propose that inherently stochastic features…