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Humans and animals learn throughout life. Such continual learning is crucial for intelligence. In this chapter, we examine the pivotal role plasticity mechanisms with complex internal synaptic dynamics could play in enabling this ability in…

Neurons and Cognition · Quantitative Biology 2024-10-21 Friedemann Zenke , Axel Laborieux

Short-term plasticity (STP) is a mechanism that stores decaying memories in synapses of the cerebral cortex. In computing practice, STP has been used, but mostly in the niche of spiking neurons, even though theory predicts that it is the…

Neural and Evolutionary Computing · Computer Science 2023-08-03 Hector Garcia Rodriguez , Qinghai Guo , Timoleon Moraitis

With memory encoding reliant on persistent changes in the properties of synapses, a key question is how can memories be maintained from days to months or a lifetime given molecular turnover? It is likely that positive feedback loops are…

Neurons and Cognition · Quantitative Biology 2019-04-18 Paul Smolen , Douglas A. Baxter , John H. Byrne

Despite substantial research into the biological basis of memory, the precise mechanisms by which experiences are encoded, stored, and retrieved in the brain remain incompletely understood. A growing body of evidence supports the engram…

Neural and Evolutionary Computing · Computer Science 2025-10-28 Daniel Szelogowski

Storage and retrieval of data in a computer memory plays a major role in system performance. Traditionally, computer memory organization is static - i.e., they do not change based on the application-specific characteristics in memory access…

Artificial Intelligence · Computer Science 2021-01-11 Prabuddha Chakraborty , Swarup Bhunia

Molecular data systems have the potential to store information at dramatically higher density than existing electronic media. Some of the first experimental demonstrations of this idea have used DNA, but nature also uses a wide diversity of…

Working memory often appears to exceed its basic span by organizing items into compact representations called chunks. Chunking can be learned over time for familiar inputs; however, it can also arise spontaneously for novel stimuli. Such…

Neurons and Cognition · Quantitative Biology 2025-09-19 Weishun Zhong , Mikhail Katkov , Misha Tsodyks

Synaptic strength can be seen as probability to propagate impulse, and according to synaptic plasticity, function could exist from propagation activity to synaptic strength. If the function satisfies constraints such as continuity and…

Neurons and Cognition · Quantitative Biology 2019-04-25 Sizhong Lan

Our brains encode many features of the sensory world into memories: we can sing along with songs we have heard before, interpret spoken and written language composed of words we have learned, and recognize faces and objects. Where are these…

Neurons and Cognition · Quantitative Biology 2025-01-22 Mark H. Histed

Understanding how biological neural networks carry out learning using spike-based local plasticity mechanisms can lead to the development of powerful, energy-efficient, and adaptive neuromorphic processing systems. A large number of…

Neural and Evolutionary Computing · Computer Science 2022-11-08 Lyes Khacef , Philipp Klein , Matteo Cartiglia , Arianna Rubino , Giacomo Indiveri , Elisabetta Chicca

Hippocampal cognitive map---a neuronal representation of the spatial environment---is broadly discussed in the computational neuroscience literature for decades. More recent studies point out that hippocampus plays a major role in producing…

Neurons and Cognition · Quantitative Biology 2017-10-18 Andrey Babichev , Yuri Dabaghian

Neural Turing Machines (NTM) contain memory component that simulates "working memory" in the brain to store and retrieve information to ease simple algorithms learning. So far, only linearly organized memory is proposed, and during…

Artificial Intelligence · Computer Science 2015-10-27 Wei Zhang , Yang Yu , Bowen Zhou

Many mathematical models of synaptic plasticity have been proposed to explain the diversity of plasticity phenomena observed in biological organisms. These models range from simple interpretations of Hebb's postulate, which suggests that…

Neurons and Cognition · Quantitative Biology 2025-08-05 Danil Tyulmankov

Traditionally, semantic models of imperative languages use an auxiliary structure which mimics memory. In this way, ownership and other encapsulation properties need to be reconstructed from the graph structure of such global memory. We…

Programming Languages · Computer Science 2019-04-24 Paola Giannini , Marco Servetto , Elena Zucca

Learning, especially rapid learning, is critical for survival. However, learning is hard: a large number of synaptic weights must be set based on noisy, often ambiguous, sensory information. In such a high-noise regime, keeping track of…

Neurons and Cognition · Quantitative Biology 2021-03-22 Laurence Aitchison , Jannes Jegminat , Jorge Aurelio Menendez , Jean-Pascal Pfister , Alex Pouget , Peter E. Latham

Associative learning is one of the key mechanisms displayed by living organisms in order to adapt to their changing environments. It was early recognized to be a general trait of complex multicellular organisms but also found in "simpler"…

Cell Behavior · Quantitative Biology 2017-01-24 Javier Macia , Blai Vidiella , Ricard Sole

Synaptic plasticity, the dynamic tuning of signal transmission strength between neurons, serves as a fundamental basis for memory and learning in biological organisms. This adaptive nature of synapses is considered one of the key features…

Mesoscale and Nanoscale Physics · Physics 2024-11-11 Yechan Noh , Alex Smolyanitsky

Associative memories are data structures that allow retrieval of stored messages from part of their content. They thus behave similarly to human brain that is capable for instance of retrieving the end of a song given its beginning. Among…

Neural and Evolutionary Computing · Computer Science 2013-07-25 Bartosz Boguslawski , Vincent Gripon , Fabrice Seguin , Frédéric Heitzmann

Various neurophysiological and cognitive functions are based on transferring information between spiking neurons via a complex system of synaptic connections. In particular, the capacity of presynaptic inputs to influence the postsynaptic…

Neurons and Cognition · Quantitative Biology 2018-10-30 Y. Dabaghian

Humans can learn in a continuous manner. Old rarely utilized knowledge can be overwritten by new incoming information while important, frequently used knowledge is prevented from being erased. In artificial learning systems, lifelong…

Computer Vision and Pattern Recognition · Computer Science 2018-10-08 Rahaf Aljundi , Francesca Babiloni , Mohamed Elhoseiny , Marcus Rohrbach , Tinne Tuytelaars