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Employing X-ray photon correlation spectroscopy we measure the kinetics and dynamics of a pressure-induced liquid-liquid phase separation (LLPS) in a water-lysozyme solution. Scattering invariants and kinetic information provide evidence…

Soft Condensed Matter · Physics 2021-07-13 M. Moron , A. Al-Masoodi , C. Lovato , M. Reiser , L. Randolph , G. Surmeier , J. Bolle , F. Westermeier , M. Sprung , R. Winter , M. Paulus , C. Gutt

Motor-proteins are responsible for transport inside cells. Harnessing their activity is key towards developing new nano-technologies, or functional biomaterials. Cytoskeleton-like networks, recently tailored in vitro, result from the…

Soft Condensed Matter · Physics 2016-06-21 Pau Guillamat , Jordi Ignés-Mullol , Francesc Sagués

Protein flotation is a process in which protein molecules are enriched by adsorption at rising bubbles. The bubbles then form a foam above the solution, where the liquid drains down and the dried foam, which is concentrated in protein, is…

Phase-separated biomolecular condensates with liquid-like properties play a key role in the organization and compartmentalization of the intracellular environment. Condensate-mediated capillary forces acting on membranes drive…

Unstructured proteins can modulate cellular responses to environmental conditions by undergoing coil-globule transitions and phase separation. However, the molecular mechanisms of these phenomena still need to be fully understood. Here, we…

Soft Condensed Matter · Physics 2023-06-28 Bernat Durà Faulí , Valentino Bianco , Giancarlo Franzese

The intriguing dynamics of a compound liquid-system comprising of water and (uncured) poly-dimethylsiloxane is explored in the present work. The viscoelastic nature of the film, coupled with the dynamics of evaporation, triggered a…

Soft Condensed Matter · Physics 2021-09-23 Sri Ganesh Subramanian , Sachin Nair , Sunando DasGupta

The non-modal self-heating mechanism driven by the velocity shear in kinematically complex magnetohydrodynamic (MHD) plasma flows is considered. The study is based on the full set of MHD equations including dissipative terms. The equations…

Solar and Stellar Astrophysics · Physics 2015-06-12 Zaza Osmanov , Andria Rogava , Stefaan Poedts

We describe several unexpected phenomena, caused by a solid-solid phase transition (gel-to-crystal) typical for all main classes of lipid substances - phospholipids, triglycerides, diglycerides, alkanes, etc. We discovered that this…

Materials Science · Physics 2020-08-26 Diana Cholakova , Desislava Glushkova , Slavka Tcholakova , Nikolai Denkov

Many biological processes are supported by special molecules, called motor proteins or molecular motors, that transport cellular cargoes along linear protein filaments and can reversibly associate to their tracks. Stimulated by these…

Statistical Mechanics · Physics 2021-11-17 Akriti Jindal , Anatoly B. Kolomeisky , Arvind Kumar Gupta

We show that a rather simple, steady modification of the streamwise velocity profile in a pipe can lead to a complete collapse of turbulence and the flow fully relaminarizes. Two different devices, a stationary obstacle (inset) and a device…

Fluid Dynamics · Physics 2018-02-06 J. Kühnen , D. Scarselli , M. Schaner , B. Hof

The issue of the stability of Pickering emulsions is tackled at a mesoscopic level using dissipative particle dynamics simulations within the Adiabatic Biased Molecular Dynamics framework. We consider the early stage of the coalescence…

Soft Condensed Matter · Physics 2017-02-08 François Sicard , Alberto Striolo

Protein conformational transitions, which are essential for function, may be driven either by entropy or enthalpy when molecular systems comprising solute and solvent molecules are the focus. Revealing thermodynamic origin of a given…

Biomolecules · Quantitative Biology 2015-05-04 Kai Wang , Shiyang Long , Zhiming Zhang , Lanru Liu , Qimeng Wang , Pu Tian

Recent experimental results suggest that the native fold, or topology, plays a primary role in determining the structure of the transition state ensemble, at least for small fast folding proteins. To investigate the extent of the…

Statistical Mechanics · Physics 2007-05-23 Cecilia Clementi , Hugh Nymeyer , Jose' Nelson Onuchic

Twinning induced plasticity (TWIP) steels are high strength metallic materials with potential for structural components in e.g. automotive applications. However, they are prone to hydrogen embrittlement (HE) and galvanic corrosion. We…

Materials Science · Physics 2023-05-03 Heena Khanchandani , Baptiste Gault

Many cellular organelles are membrane-bound structures with complex membrane composition and shape. Their shapes have been observed to depend on the metabolic state of the organelle, and the mechanisms that couple biochemical pathways and…

Soft Condensed Matter · Physics 2023-07-19 Toni V. Mendes , Jonas Ranft , Hélène Berthoumieux

Step-emulsification is a microfluidic technique for droplet generation which relies on the abrupt decrease of confinement of a liquid filament surrounded by a continuous phase. A striking feature of this geometry is the transition between…

Fluid Dynamics · Physics 2014-09-19 M. Hein , S. Afkhami , R. Seemann , L. Kondic

We use coarse grained molecular dynamics simulations to investigate diffusion properties of sheared lipid membranes with embedded transmembrane proteins. In membranes without proteins, we find normal in-plane diffusion of lipids in all flow…

Biological Physics · Physics 2013-09-10 Atefeh Khoshnood , Mir Abbas Jalali

The coffee-ring effect is a universal feature of evaporating sessile droplets with pinned contact line, wherein solutes or particles are advected to the droplet's edge due to evaporation-driven flows. While existing models have successfully…

In addition to the biologically active monomer of the protein Insulin circulating in human blood, the molecule also exists in dimeric and hexameric forms that are used as storage. The Insulin monomer contains two distinct surfaces, namely…

Biomolecules · Quantitative Biology 2013-12-24 Kushal Bagchi , Susmita Roy

We implement the replica exchange molecular dynamics algorithm to study the interactions of a model peptide (WALP-16) with an explicitly represented DPPC membrane bilayer. We observe the spontaneous, unbiased insertion of WALP-16 into the…

Biomolecules · Quantitative Biology 2007-05-23 Hugh Nymeyer , Thomas B. Woolf , Angel E. Garcia