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Multiple Instance Learning (MIL) involves predicting a single label for a bag of instances, given positive or negative labels at bag-level, without accessing to label for each instance in the training phase. Since a positive bag contains…

Machine Learning · Computer Science 2020-09-09 Beomjo Shin , Junsu Cho , Hwanjo Yu , Seungjin Choi

Accurately predicting and detecting interstitial lung disease (ILD) patterns given any computed tomography (CT) slice without any pre-processing prerequisites, such as manually delineated regions of interest (ROIs), is a clinically…

Computer Vision and Pattern Recognition · Computer Science 2017-01-23 Mingchen Gao , Ziyue Xu , Le Lu , Adam P. Harrison , Ronald M. Summers , Daniel J. Mollura

Multiple Instance Learning (MIL) is increasingly being used as a support tool within clinical settings for pathological diagnosis decisions, achieving high performance and removing the annotation burden. However, existing approaches for…

Computer Vision and Pattern Recognition · Computer Science 2025-08-01 Sungrae Hong , Kyungeun Kim , Juhyeon Kim , Sol Lee , Jisu Shin , Chanjae Song , Mun Yong Yi

Randomized controlled trials estimate average treatment effects, but treatment response heterogeneity motivates personalized approaches. A critical question is whether statistically detectable heterogeneity translates into improved…

Machine Learning · Computer Science 2026-02-10 Cristian Minoccheri , Sophia Tesic , Kayvan Najarian , Ryan Stidham

In the last years, the weakly supervised paradigm of multiple instance learning (MIL) has become very popular in many different areas. A paradigmatic example is computational pathology, where the lack of patch-level labels for whole-slide…

Computer Vision and Pattern Recognition · Computer Science 2023-10-31 Pablo Morales-Álvarez , Arne Schmidt , José Miguel Hernández-Lobato , Rafael Molina

In recent years, the availability of digitized Whole Slide Images (WSIs) has enabled the use of deep learning-based computer vision techniques for automated disease diagnosis. However, WSIs present unique computational and algorithmic…

Image and Video Processing · Electrical Eng. & Systems 2021-06-15 Yash Sharma , Aman Shrivastava , Lubaina Ehsan , Christopher A. Moskaluk , Sana Syed , Donald E. Brown

Traditional supervised learning tasks require a label for every instance in the training set, but in many real-world applications, labels are only available for collections (bags) of instances. This problem setting, known as multiple…

Computer Vision and Pattern Recognition · Computer Science 2023-05-23 Georg Wölflein , Lucie Charlotte Magister , Pietro Liò , David J. Harrison , Ognjen Arandjelović

Prostate cancer grading using the ISUP system (International Society of Urological Pathology) for treatment decisions is highly subjective and requires considerable expertise. Despite advances in computer-aided diagnosis systems, few have…

Computer Vision and Pattern Recognition · Computer Science 2025-01-28 Riddhasree Bhattacharyya , Surochita Pal Das , Sushmita Mitra

Analyzing high resolution whole slide images (WSIs) with regard to information across multiple scales poses a significant challenge in digital pathology. Multi-instance learning (MIL) is a common solution for working with high resolution…

Previous approaches to the task of implicit discourse relation recognition (IDRR) generally view it as a classification task. Even with pre-trained language models, like BERT and RoBERTa, IDRR still relies on complicated neural networks…

Computation and Language · Computer Science 2024-09-24 Yiheng Wu , Junhui Li , Muhua Zhu

Self-supervised instance discrimination is an effective contrastive pretext task to learn feature representations and address limited medical image annotations. The idea is to make features of transformed versions of the same images similar…

Computer Vision and Pattern Recognition · Computer Science 2022-11-17 Yejia Zhang , Xinrong Hu , Nishchal Sapkota , Yiyu Shi , Danny Z. Chen

Multi-instance learning (MIL) is widely used in the computer-aided interpretation of pathological Whole Slide Images (WSIs) to solve the lack of pixel-wise or patch-wise annotations. Often, this approach directly applies "natural image…

Multiple instance learning exhibits a powerful approach for whole slide image-based diagnosis in the absence of pixel- or patch-level annotations. In spite of the huge size of hole slide images, the number of individual slides is often…

New intent discovery is a crucial capability for task-oriented dialogue systems. Existing methods focus on transferring in-domain (IND) prior knowledge to out-of-domain (OOD) data through pre-training and clustering stages. They either…

Computation and Language · Computer Science 2024-10-29 Yimin Deng , Yuxia Wu , Guoshuai Zhao , Li Zhu , Xueming Qian

The whole slide histopathology images (WSIs) play a critical role in gastric cancer diagnosis. However, due to the large scale of WSIs and various sizes of the abnormal area, how to select informative regions and analyze them are quite…

Computer Vision and Pattern Recognition · Computer Science 2020-10-14 Shujun Wang , Yaxi Zhu , Lequan Yu , Hao Chen , Huangjing Lin , Xiangbo Wan , Xinjuan Fan , Pheng-Ann Hen

Large-scale volumetric medical images with annotation are rare, costly, and time prohibitive to acquire. Self-supervised learning (SSL) offers a promising pre-training and feature extraction solution for many downstream tasks, as it only…

Computer Vision and Pattern Recognition · Computer Science 2023-03-16 Ke Yu , Li Sun , Junxiang Chen , Max Reynolds , Tigmanshu Chaudhary , Kayhan Batmanghelich

In computational pathology, multiple instance learning (MIL) is widely used to circumvent the computational impasse in giga-pixel whole slide image (WSI) analysis. It usually consists of two stages: patch-level feature extraction and…

Image and Video Processing · Electrical Eng. & Systems 2023-09-21 Beidi Zhao , Wenlong Deng , Zi Han , Li , Chen Zhou , Zuhua Gao , Gang Wang , Xiaoxiao Li

Self-Supervised Learning (SSL) has emerged as a promising approach in computer vision, enabling networks to learn meaningful representations from large unlabeled datasets. SSL methods fall into two main categories: instance discrimination…

Computer Vision and Pattern Recognition · Computer Science 2026-05-01 Alina Ciocarlan , Sidonie Lefebvre , Sylvie Le Hégarat-Mascle , Arnaud Woiselle

Predicting breast cancer recurrence risk is a critical clinical challenge. This study investigates the potential of computational pathology to stratify patients using deep learning on routine Hematoxylin and Eosin (H&E) stained whole-slide…

Computer Vision and Pattern Recognition · Computer Science 2025-12-23 Jinqiu Chen , Huyan Xu

When applying multi-instance learning (MIL) to make predictions for bags of instances, the prediction accuracy of an instance often depends on not only the instance itself but also its context in the corresponding bag. From the viewpoint of…

Computer Vision and Pattern Recognition · Computer Science 2022-04-25 Tiancheng Lin , Hongteng Xu , Canqian Yang , Yi Xu