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Multi-Instance Learning (MIL) has shown impressive performance for histopathology whole slide image (WSI) analysis using bags or pseudo-bags. It involves instance sampling, feature representation, and decision-making. However, existing…

Computer Vision and Pattern Recognition · Computer Science 2024-03-14 Tingting Zheng , Kui Jiang , Hongxun Yao

Digital pathology has revolutionized the field by enabling the digitization of tissue samples into whole slide images (WSIs). However, the high resolution and large size of WSIs present significant challenges when it comes to applying Deep…

Computer Vision and Pattern Recognition · Computer Science 2025-07-03 Ali Mammadov , Loïc Le Folgoc , Guillaume Hocquet , Pietro Gori

Crohn's Disease (CD) and Ulcerative Colitis (UC) are the two main Inflammatory Bowel Disease (IBD) types. We developed deep learning models to identify histological disease features for both CD and UC using only endoscopic labels. We…

Self-supervised learning is emerging in fine-grained visual recognition with promising results. However, existing self-supervised learning methods are often susceptible to irrelevant patterns in self-supervised tasks and lack the capability…

Computer Vision and Pattern Recognition · Computer Science 2024-12-03 ShuaiHeng Li , Qing Cai , Fan Zhang , Menghuan Zhang , Yangyang Shu , Zhi Liu , Huafeng Li , Lingqiao Liu

Multi-instance learning (MIL) is a form of weakly supervised learning where a single class label is assigned to a bag of instances while the instance-level labels are not available. Training classifiers to accurately determine the bag label…

Computer Vision and Pattern Recognition · Computer Science 2020-06-11 Bin Li , Kevin W. Eliceiri

Multiple instance learning (MIL) has been increasingly used in the classification of histopathology whole slide images (WSIs). However, MIL approaches for this specific classification problem still face unique challenges, particularly those…

Computer Vision and Pattern Recognition · Computer Science 2022-03-24 Hongrun Zhang , Yanda Meng , Yitian Zhao , Yihong Qiao , Xiaoyun Yang , Sarah E. Coupland , Yalin Zheng

We propose DiRL, a Diversity-inducing Representation Learning technique for histopathology imaging. Self-supervised learning techniques, such as contrastive and non-contrastive approaches, have been shown to learn rich and effective…

Computer Vision and Pattern Recognition · Computer Science 2023-09-13 Saarthak Kapse , Srijan Das , Jingwei Zhang , Rajarsi R. Gupta , Joel Saltz , Dimitris Samaras , Prateek Prasanna

Existing Class Incremental Learning (CIL) methods are based on a supervised classification framework sensitive to data labels. When updating them based on the new class data, they suffer from catastrophic forgetting: the model cannot…

Machine Learning · Computer Science 2021-11-23 Zixuan Ni , Siliang Tang , Yueting Zhuang

Multiple Instance Learning (MIL) is a cornerstone approach in computational pathology (CPath) for generating clinically meaningful slide-level embeddings from gigapixel tissue images. However, MIL often struggles with small, weakly…

Computer Vision and Pattern Recognition · Computer Science 2025-06-12 Daniel Shao , Richard J. Chen , Andrew H. Song , Joel Runevic , Ming Y. Lu , Tong Ding , Faisal Mahmood

Unsupervised feature learning has made great strides with contrastive learning based on instance discrimination and invariant mapping, as benchmarked on curated class-balanced datasets. However, natural data could be highly correlated and…

Computer Vision and Pattern Recognition · Computer Science 2021-05-18 Xudong Wang , Ziwei Liu , Stella X. Yu

Deep neural classifiers trained with cross-entropy loss (CE loss) often suffer from poor calibration, necessitating the task of out-of-distribution (OOD) detection. Traditional supervised OOD detection methods require expensive manual…

Computation and Language · Computer Science 2023-05-25 Dheeraj Mekala , Adithya Samavedhi , Chengyu Dong , Jingbo Shang

Integrated Gradients is a well-known technique for explaining deep learning models. It calculates feature importance scores by employing a gradient based approach computing gradients of the model output with respect to input features and…

Computation and Language · Computer Science 2024-12-06 Swarnava Sinha Roy , Ayan Kundu

Multiple Instance Learning (MIL) is a weakly-supervised problem in which one label is assigned to the whole bag of instances. An important class of MIL models is instance-based, where we first classify instances and then aggregate those…

Image and Video Processing · Electrical Eng. & Systems 2024-03-13 Łukasz Struski , Dawid Rymarczyk , Arkadiusz Lewicki , Robert Sabiniewicz , Jacek Tabor , Bartosz Zieliński

Recent advances in prototypical learning have shown remarkable potential to provide useful decision interpretations associating activation maps and predictions with class-specific training prototypes. Such prototypical learning has been…

Computer Vision and Pattern Recognition · Computer Science 2025-04-07 Chong Wang , Fengbei Liu , Yuanhong Chen , Helen Frazer , Gustavo Carneiro

We consider machine-learning-based thyroid-malignancy prediction from cytopathology whole-slide images (WSI). Multiple instance learning (MIL) approaches, typically used for the analysis of WSIs, divide the image (bag) into patches…

Contrastive learning and self-supervised techniques have gained prevalence in computer vision for the past few years. It is essential for medical image analysis, which is often notorious for its lack of annotations. Most existing…

Image and Video Processing · Electrical Eng. & Systems 2022-03-07 Jun Li , Quan Quan , S. Kevin Zhou

Self-supervised learning (SSL) has recently shown tremendous potential to learn generic visual representations useful for many image analysis tasks. Despite their notable success, the existing SSL methods fail to generalize to downstream…

Computer Vision and Pattern Recognition · Computer Science 2021-10-07 Chetan L Srinidhi , Anne L Martel

Recent research in self-supervised learning (SSL) has shown its capability in learning useful semantic representations from images for classification tasks. Through our work, we study the usefulness of SSL for Fine-Grained Visual…

Computer Vision and Pattern Recognition · Computer Science 2021-05-20 Muhammad Maaz , Hanoona Abdul Rasheed , Dhanalaxmi Gaddam

In-context learning (ICL) enables medical image segmentation models to adapt to new anatomical structures from limited examples, reducing the clinical annotation burden. However, standard ICL methods typically rely on dense, global…

Computer Vision and Pattern Recognition · Computer Science 2026-04-23 T. Camaret Ndir , Marco Reisert , Robin T. Schirrmeister

Multiple Instance Learning (MIL) offers a natural solution for settings where only coarse, bag-level labels are available, without having access to instance-level annotations. This is usually the case in digital pathology, which consists of…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Andreas Lolos , Stergios Christodoulidis , Aris L. Moustakas , Jose Dolz , Maria Vakalopoulou
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