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Plasmonic metamaterials can be used to enhance mid-infrared sensors and detectors for immunosensing applications. The major challenge is to integrate these technologies in low-cost, compact, and promising platforms. In this study, as an…

An exact, analytic solution for a simple electrostatic model applicable to biomolecular recognition is presented. In the model, a layer of high dielectric constant material (representative of the solvent, water) whose thickness may vary…

Classical Physics · Physics 2013-05-29 T. P. Doerr , Yi-Kuo Yu

Targeted light delivery into biological tissue is needed in applications such as optogenetic stimulation of the brain and in vivo functional or structural imaging of tissue. These applications require very compact, soft, and flexible…

Applied Physics · Physics 2020-09-22 Jay W. Reddy , Maya Lassiter , Maysamreza Chamanzar

We propose and numerically demonstrate a novel strategy to achieve dual-band symmetry-protected bound states in the continuum (BICs) based on a nanodisk tetramer metasurface for lasing generation. The method involves breaking the in-plane…

Optics · Physics 2024-11-27 T. Wang , W. Z. Di , W. E. I. Sha , R. P. Zaccaria

Highly sensitive and selective label free devices for real-time identification of specific biomarkers are expected to significantly impact the biosensing field. The ability of plasmonic systems to confine the light in nanometer volume and…

A multimode microcavity sensor based on a self-interference microring resonator is demonstrated experimentally. The proposed multimode sensing method is implemented by recording wideband transmission spectra that consist of multiple…

In recent years the NHS has been having increased difficulty seeing all low-risk patients, this includes but not limited to suspected osteoarthritis (OA) patients. To help address the increased waiting lists and shortages of staff, we…

Computer Vision and Pattern Recognition · Computer Science 2023-04-27 Kai Armstrong , Lei Zhang , Yan Wen , Alexander P. Willmott , Paul Lee , Xujioing Ye

Whispering gallery mode (WGM) laser sensors, utilizing the interaction between the in-plane evanescent field and the surface vicinity, provide enhanced sensitivity in label-free sensing for bioanalysis and disease screening. However, the…

Optics · Physics 2025-08-25 Xiaolu Cui , Jiyang Ma , Hao Wu , Shuoying Zhao , Xubiao Peng , Chuyu Li , Ruiqi Ming , Qing Zhao

Oxygen (O2)-sensing matrices are promising tools for the live monitoring of extracellular O2 consumption levels in long-term cell cultures. In this study, ratiometric O2-sensing membranes were prepared by electrospinning, an easy, low-cost,…

Accurately recognizing health-related conditions from wearable data is crucial for improved healthcare outcomes. To improve the recognition accuracy, various approaches have focused on how to effectively fuse information from multiple…

Machine Learning · Computer Science 2022-02-18 Huiyuan Yang , Han Yu , Kusha Sridhar , Thomas Vaessen , Inez Myin-Germeys , Akane Sano

Microplastics (MPs) are ubiquitous in all ecosystems, affecting wildlife and, ultimately, human health. The complexity of natural samples plus the unspecificity of their treatments to isolate polymers renders the characterization of…

Instrumentation and Detectors · Physics 2025-04-01 Adrian Lopez-Rosales , Jose Andrade , Borja Ferreiro , Soledad Muniategui

Quantum sensing technologies offer transformative potential for ultra-sensitive biomedical sensing, yet their clinical translation remains constrained by classical noise limits and a reliance on macroscopic ensembles. We propose a unifying…

A micro-ring-resonator (MRR) optical biosensor based on the evanescent field sensing mechanism has been extensively studied due to its high sensitivity and compact device size. However, a suitable on-chip integrated spectrometer device has…

Optics · Physics 2022-07-19 Kyoung Min Yoo , May Hlaing , Sourabh Jain , James Fan , Yue An , Ray T. Chen

In this study, we present a highly sensitive Surface Plasmon Resonance (SPR)-based biosensor integrated with a circular-lattice Photonic Crystal Fiber (PCF) for early-stage cancer detection. The proposed sensor leverages the synergy between…

Optical metasurfaces supporting resonances with high quality factors offer an outstanding platform for applications such as non-linear optics, light guiding, lasing, sensing, light-matter coupling, and quantum optics. However, their…

As the global population continues to age, there is an increasing demand for ways to accurately quantify the biological processes underlying aging. Biological age, unlike chronological age, reflects an individual's physiological state,…

Quantitative Methods · Quantitative Biology 2025-08-29 Jared A Kushner , Mohit Pandey , Sandeep , S Kohli

We review principles and trends in the use of semiconductor nanowires (NWs) as gain media for stimulated emission and lasing. Semiconductor nanowires have recently been widely studied for use in integrated optoelectronic devices, such as…

Mesoscale and Nanoscale Physics · Physics 2018-09-06 C. Couteau , A. Larrue , C. Wilhelm , C. Soci

Molecules are emerging as new benchmark for metrology and fundamental physics research, driving the demand for spectroscopic techniques combining high sensitivity and resolution. Photoacoustic spectroscopy has proven to combine high…

Fluorescence imaging allows for non-invasively visualizing and measuring key physiological parameters like pH and dissolved oxygen. In our work, we created two ratiometric fluorescent microsensors designed for accurately tracking dissolved…

Polymer micro- and nano-fibers, made of organic light-emitting materials with optical gain, show interesting lasing properties. Fibers with diameters from few tens of nm to few microns can be fabricated by electrospinning, a method based on…

Materials Science · Physics 2013-12-02 Andrea Camposeo , Luana Persano , Dario Pisignano