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The growing interest in bio-inspired materials is driven by the need for increasingly targeted and efficient devices that also have a low ecological impact. These devices often use specially developed materials (e.g., polymers, aptamers,…
Recording of transient absorption microscopy images requires fast detection of minute optical density changes, which is typically achieved with high-repetition-rate laser sources and lock-in detection. Here, we present a highly flexible and…
Genetic analysis methods are foundational to advancing personalized and preventative medicine, accelerating disease diagnostics, and monitoring the health of organisms and ecosystems. Current nucleic acid technologies such as polymerase…
This work demonstrates the Nd:YAG waveguide laser as an efficient platform for the bio-sensing. The waveguide was fabricated in the Nd:YAG crystal by the cooperation of the ultrafast laser writing and ion irradiation. As the laser…
Wireless all-analog biosensor design for concurrent microfluidic and physiological signal monitoring is presented in this work. The key component is an all-analog circuit capable of compressing two analog sources into one analog signal by…
The mathematical theory of compressed sensing (CS) asserts that one can acquire signals from measurements whose rate is much lower than the total bandwidth. Whereas the CS theory is now well developed, challenges concerning hardware…
Antibody-functionalized silicon nanowire field-effect transistors have been shown to exhibit excellent analyte detection sensitivity enabling sensing of analyte concentrations at levels not readily accessible by other methods. One example…
Here we propose a new design paradigm for a superconducting nanowire single photon detector that uses a multi-layer architecture that places the electric leads beneath the nanowires. This allows for a very large number of detector elements,…
With the development of wearable technologies, a new kind of healthcare data has become valuable as medical information. These data provide meaningful information regarding an individual's physiological and psychological states, such as…
An effective biosensor based on two-dimensional (2D) Co-ZIF-L nanosheets for sensitive electrochemical non-enzymatic glucose detection is developed, which exhibits high electrocalalytic activities towards glucose due to the ordered porous…
Biomarkers abound in many areas of clinical research, and often investigators are interested in combining them for diagnosis, prognosis, or screening. In many applications, the true positive rate for a biomarker combination at a…
Two-dimensional (2D) materials have been used extensively in various fields due to their unique physical and chemical properties. Among their diverse applications, field-effect transistor biosensors (bio-FETs) promise a brilliant prospect…
Endoscopes featuring a miniaturized design have significantly enhanced operational flexibility, portability, and diagnostic capability while substantially reducing the invasiveness of medical procedures. Recently, single-use endoscopes…
Single-photon detection via absorption in current-biased nanoscale superconducting structures has become a preferred technology in quantum optics and related fields. Single-mode fiber packaged devices have seen new records set in detection…
Optical detection of nanoscale objects without relying on fluorescence is a current challenge due to their extremely weak interaction with light. Resonator-enhanced absorption microscopy is a novel tool to heavily boost the light-matter…
Sensitive microwave detectors are critical instruments in radioastronomy, dark matter axion searches, and superconducting quantum information science. The conventional strategy towards higher-sensitivity bolometry is to nanofabricate an…
Herein, the concept of point of darkness based on polarized light phase difference and absorption of light is demonstrated by simulations using low refractive index and extinction coefficient semiconductor and dielectric, and high…
Scientific discovery in digital health requires converting continuous physiological signals from wearable devices into clinically actionable biomarkers. We introduce CoDaS (AI Co-Data-Scientist), a multi-agent system that structures…
We present a proof-of-principle study of superconducting single photon detectors (SSPD) for the detection of individual neutral molecules/nanoparticles at low energies. The new detector is applied to characterize a laser desorption source…
Advances in wearable computing and AI have increased interest in leveraging PPG for health monitoring over the past decade. One of the biggest challenges in developing health algorithms based on such biosignals is the sparsity of clinical…