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Classical compartmental models in epidemiology often assume a homogeneous population for simplicity, which neglects the inherent heterogeneity among individuals. This assumption frequently leads to inaccurate predictions when applied to…

Populations and Evolution · Quantitative Biology 2024-09-09 Ning Jiang , Weiqi Chu , Yao Li

A key challenge in building effective regression models for large and diverse populations is accounting for patient heterogeneity. An example of such heterogeneity is in health system risk modeling efforts where different combinations of…

Methodology · Statistics 2022-12-26 Jared D. Huling , Menggang Yu

In order to model an epidemic, different approaches can be adopted. Mainly, the deterministic approach and the stochastic one. Recently, a large amount of literature has been published using the two approaches. The aim of this paper is to…

Populations and Evolution · Quantitative Biology 2023-01-30 Mohamed Mehdaoui

Effective public health decisions require early reliable inference of infectious disease properties. In this paper we assess the ability to infer infectious disease attributes from population-level stochastic epidemic trajectories. In…

Populations and Evolution · Quantitative Biology 2026-01-14 Mark P. Rast , Luke I. Rast

Compartmental models have long served as important tools in mathematical epidemiology, with their usefulness highlighted by the recent COVID-19 pandemic. However, most of the classical models fail to account for certain features of this…

Dynamical Systems · Mathematics 2023-08-21 Monique Chyba , Taylor Klotz , Yuriy Mileyko , Corey Shanbrom

Since roughly a decade ago, network science has focused among others on the problem of how the spreading of diseases depends on structural patterns. Here, we contribute to further advance our understanding of epidemic spreading processes by…

Computational Physics · Physics 2012-06-11 Sergio Gomez , Jesus Gomez-Gardenes , Yamir Moreno , Alex Arenas

The duration, type and structure of connections between individuals in real-world populations play a crucial role in how diseases invade and spread. Here, we incorporate the aforementioned heterogeneities into a model by considering a…

Physics and Society · Physics 2018-04-05 Rosanna C Barnard , Istvan Z Kiss , Luc Berthouze , Joel C Miller

A significant proportion of the infections driving the current {SARS-CoV-2} pandemic are transmitted asymptomatically. Here we introduce and study a simple epidemic model with separate compartments comprising asymptomatic and symptomatic…

Populations and Evolution · Quantitative Biology 2022-10-12 Maurice Görtz , Joachim Krug

The propagation of infectious diseases and its impact on individuals play a major role in disease dynamics, and it is important to incorporate population heterogeneity into efforts to study diseases. As a simplistic but illustrative…

Populations and Evolution · Quantitative Biology 2019-07-24 Juan G. Calvo , Alberto Hernández , Mason A. Porter , Fabio Sanchez

Mathematical modelling of the spread of epidemics has been an interesting challenge in the field of epidemiology. The SIR Model proposed by Kermack and McKendrick in 1927 is a prototypical model of epidemiology. However, it has its…

Populations and Evolution · Quantitative Biology 2021-04-13 Agniva Datta , Muktish Acharyya

The effect of public health interventions on an epidemic are often estimated by adding the intervention to epidemic models. During the Covid-19 epidemic, numerous papers used such methods for making scenario predictions. The majority of…

Methodology · Statistics 2024-10-16 Heejong Bong , Valérie Ventura , Larry Wasserman

The duration of the infectious period is a crucial determinant of the ability of an infectious disease to spread. We consider an epidemic model that is network based and non-Markovian, containing classic Kermack-McKendrick, pairwise,…

Populations and Evolution · Quantitative Biology 2018-05-25 Robert R. Wilkinson , Kieran J. Sharkey

We investigate the application of a framework for sparse model identification of differential equations from timeseries data in the context of compartmental models in epidemiology. Such frameworks often seek a sparse representation from a…

Optimization and Control · Mathematics 2025-10-23 Manuchehr Aminian , Kristin M. Kurianski

A compartment epidemic model for infectious disease spreading is investigated, where movement of individuals is governed by spatial diffusion. The model includes infection age of the infected individuals and assumes a logistic growth of the…

Analysis of PDEs · Mathematics 2023-06-28 Christoph Walker

Compartmental epidemic models have been widely used for predicting the course of epidemics, from estimating the basic reproduction number to guiding intervention policies. Studies commonly acknowledge these models' assumptions but less…

Populations and Evolution · Quantitative Biology 2022-11-23 Alexander F. Siegenfeld , Pratyush K. Kollepara , Yaneer Bar-Yam

We develop a stochastic two-patch epidemic model with nonlinear recidivism to investigate infectious disease dynamics in heterogeneous populations. Extending a deterministic framework, we introduce stochasticity to account for random…

Populations and Evolution · Quantitative Biology 2024-05-21 Juan G. Calvo , Mario I. Simoy , Juan P. Aparicio , José E. Chacón , Fabio Sanchez

A key problem in modelling the evolution dynamics of infectious diseases is the mathematical representation of the mechanism of transmission of the contagion. Models with a finite number of subpopulations can be described via systems of…

Optimization and Control · Mathematics 2017-03-09 Sebastian Anita , Vincenzo Capasso

The paper presents an algorithm for syndromic surveillance of an epidemic outbreak formulated in the context of stochastic nonlinear filtering. The dynamics of the epidemic is modeled using a generalized compartmental epidemiological model…

Quantitative Methods · Quantitative Biology 2011-10-24 Alex Skvortsov , Branko Ristic

We study an infection-age structured epidemic model in which both the infectivity and the rate of loss of immunity depend on the time-since-infection. The model can be equivalently viewed as a nonlinear renewal equation for the incidence of…

Dynamical Systems · Mathematics 2025-11-13 Francesca Scarabel , Harry Coldwell , Tyler Cassidy

We develop a new structured compartmental model for the coevolutionary dynamics between susceptible and infectious individuals in heterogeneous SI epidemiological systems. In this model, the susceptible compartment is structured by a…

Populations and Evolution · Quantitative Biology 2024-10-10 Tommaso Lorenzi , Elisa Paparelli , Andrea Tosin