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Pretraining on large-scale datasets has been shown to improve transformer generalizability, even for out-of-domain (OOD) modalities and tasks. However, two common assumptions often fail under OOD transfer: that downstream datasets can be…

Training end-to-end networks for classifying gigapixel size histopathological images is computationally intractable. Most approaches are patch-based and first learn local representations (patch-wise) before combining these local…

Image and Video Processing · Electrical Eng. & Systems 2020-07-28 Sachin Mehta , Ximing Lu , Donald Weaver , Joann G. Elmore , Hannaneh Hajishirzi , Linda Shapiro

Whole slide image (WSI) refers to a type of high-resolution scanned tissue image, which is extensively employed in computer-assisted diagnosis (CAD). The extremely high resolution and limited availability of region-level annotations make…

Computer Vision and Pattern Recognition · Computer Science 2023-09-06 Ruijie Zhang , Qiaozhe Zhang , Yingzhuang Liu , Hao Xin , Yan Liu , Xinggang Wang

Large-scale pre-training models have promoted the development of histopathology image analysis. However, existing self-supervised methods for histopathology images primarily focus on learning patch features, while there is a notable gap in…

Computer Vision and Pattern Recognition · Computer Science 2024-12-09 Kun Wu , Zhiguo Jiang , Kunming Tang , Jun Shi , Fengying Xie , Wei Wang , Haibo Wu , Yushan Zheng

Histopathology is critical for the diagnosis of many diseases, including cancer. These protocols typically require pathologists to manually evaluate slides under a microscope, which is time-consuming and subjective, leading to interest in…

Computer Vision and Pattern Recognition · Computer Science 2023-03-07 Kianoush Falahkheirkhah , Alex Lu , David Alvarez-Melis , Grace Huynh

Histopathology remains the gold standard for cancer diagnosis because it provides detailed cellular-level assessment of tissue morphology. However, manual histopathological examination is time-consuming, labour-intensive, and subject to…

Computer Vision and Pattern Recognition · Computer Science 2026-03-13 Ravi Mosalpuri , Mohammed Abdelsamea , Ahmed Karam Eldaly

Evaluating lesion progression and treatment response via longitudinal lesion tracking plays a critical role in clinical practice. Automated approaches for this task are motivated by prohibitive labor costs and time consumption when lesion…

Computer Vision and Pattern Recognition · Computer Science 2022-12-13 Wen Tang , Han Kang , Haoyue Zhang , Pengxin Yu , Corey W. Arnold , Rongguo Zhang

Directly predicting human epidermal growth factor receptor 2 (HER2) status from widely available hematoxylin and eosin (HE)-stained whole slide images (WSIs) can reduce technical costs and expedite treatment selection. Accurately predicting…

Image and Video Processing · Electrical Eng. & Systems 2024-02-28 Bao Li , Zhenyu Liu , Lizhi Shao , Bensheng Qiu , Hong Bu , Jie Tian

Transformer-based methods have demonstrated strong potential in hyperspectral pansharpening by modeling long-range dependencies. However, their effectiveness is often limited by redundant token representations and a lack of multi-scale…

Computer Vision and Pattern Recognition · Computer Science 2025-08-12 Hongkun Jin , Hongcheng Jiang , Zejun Zhang , Yuan Zhang , Jia Fu , Tingfeng Li , Kai Luo

Histopathological whole slide images (WSIs) classification has become a foundation task in medical microscopic imaging processing. Prevailing approaches involve learning WSIs as instance-bag representations, emphasizing significant…

Computer Vision and Pattern Recognition · Computer Science 2024-03-13 Jiawen Li , Yuxuan Chen , Hongbo Chu , Qiehe Sun , Tian Guan , Anjia Han , Yonghong He

This paper presents an autoencoder-based neural network architecture to compress histopathological images while retaining the denser and more meaningful representation of the original images. Current research into improving compression…

Image and Video Processing · Electrical Eng. & Systems 2023-05-15 Agnes Barsi , Suvendu Chandan Nayak , Sasmita Parida , Raj Mani Shukla

In pathology, whole-slide images (WSI) based survival prediction has attracted increasing interest. However, given the large size of WSIs and the lack of pathologist annotations, extracting the prognostic information from WSIs remains a…

Image and Video Processing · Electrical Eng. & Systems 2021-10-25 Shuai Jiang , Arief A. Suriawinata , Saeed Hassanpour

Histopathology image analysis can be considered as a Multiple instance learning (MIL) problem, where the whole slide histopathology image (WSI) is regarded as a bag of instances (i.e, patches) and the task is to predict a single class label…

Computer Vision and Pattern Recognition · Computer Science 2019-06-28 Meng Li , Lin Wu , Arnold Wiliem , Kun Zhao , Teng Zhang , Brian C. Lovell

We present a novel method that extends the self-attention mechanism of a vision transformer (ViT) for more accurate object detection across diverse datasets. ViTs show strong capability for image understanding tasks such as object…

Computer Vision and Pattern Recognition · Computer Science 2024-12-30 Tan Nguyen , Coy D. Heldermon , Corey Toler-Franklin

The Segment Anything Model (SAM) marks a significant advancement in segmentation models, offering robust zero-shot abilities and dynamic prompting. However, existing medical SAMs are not suitable for the multi-scale nature of whole-slide…

Computer Vision and Pattern Recognition · Computer Science 2024-03-19 Hong Liu , Haosen Yang , Paul J. van Diest , Josien P. W. Pluim , Mitko Veta

Whole slide image (WSI) analysis presents significant computational challenges due to the massive number of patches in gigapixel images. While transformer architectures excel at modeling long-range correlations through self-attention, their…

Computer Vision and Pattern Recognition · Computer Science 2025-05-27 Zhengrui Guo , Qichen Sun , Jiabo Ma , Lishuang Feng , Jinzhuo Wang , Hao Chen

Transformer architecture has emerged to be successful in a number of natural language processing tasks. However, its applications to medical vision remain largely unexplored. In this study, we present UTNet, a simple yet powerful hybrid…

Computer Vision and Pattern Recognition · Computer Science 2021-09-29 Yunhe Gao , Mu Zhou , Dimitris Metaxas

Biomedical image classification requires capturing of bio-informatics based on specific feature distribution. In most of such applications, there are mainly challenges due to limited availability of samples for diseased cases and imbalanced…

Computer Vision and Pattern Recognition · Computer Science 2025-10-23 Arun K. Sharma , Nishchal K. Verma

Medical image segmentation has seen significant improvements with transformer models, which excel in grasping far-reaching contexts and global contextual information. However, the increasing computational demands of these models,…

Computer Vision and Pattern Recognition · Computer Science 2023-09-04 Reza Azad , Leon Niggemeier , Michael Huttemann , Amirhossein Kazerouni , Ehsan Khodapanah Aghdam , Yury Velichko , Ulas Bagci , Dorit Merhof

In modern cancer diagnostics, Whole Slide Imaging (WSI) is widely used to digitize tissue specimens for detailed, high-resolution examination; however, other diagnostic approaches, such as liquid biopsy and molecular testing, are also…

Computer Vision and Pattern Recognition · Computer Science 2025-07-02 Seyed Kahaki , Alexander R. Webber , Ghada Zamzmi , Adarsh Subbaswamy , Rucha Deshpande , Aldo Badano