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Tissue typology annotation in Whole Slide histological images is a complex and tedious, yet necessary task for the development of computational pathology models. We propose to address this problem by applying Open Set Recognition techniques…

Computer Vision and Pattern Recognition · Computer Science 2022-06-28 Adrian Galdran , Katherine J. Hewitt , Narmin L. Ghaffari , Jakob N. Kather , Gustavo Carneiro , Miguel A. González Ballester

Histopathology whole slide images (WSIs) play a very important role in clinical studies and serve as the gold standard for many cancer diagnoses. However, generating automatic tools for processing WSIs is challenging due to their enormous…

Computer Vision and Pattern Recognition · Computer Science 2022-09-28 Jingwei Zhang , Xin Zhang , Ke Ma , Rajarsi Gupta , Joel Saltz , Maria Vakalopoulou , Dimitris Samaras

Transformer-based methods have shown impressive performance in image restoration tasks, such as image super-resolution and denoising. However, we find that these networks can only utilize a limited spatial range of input information through…

Computer Vision and Pattern Recognition · Computer Science 2025-11-04 Xiangyu Chen , Xintao Wang , Wenlong Zhang , Xiangtao Kong , Yu Qiao , Jiantao Zhou , Chao Dong

Attention-based models, exemplified by the Transformer, can effectively model long range dependency, but suffer from the quadratic complexity of self-attention operation, making them difficult to be adopted for high-resolution image…

Computer Vision and Pattern Recognition · Computer Science 2021-12-28 Long Zhao , Zizhao Zhang , Ting Chen , Dimitris N. Metaxas , Han Zhang

Accurate classification of Whole Slide Images (WSIs) and Regions of Interest (ROIs) is a fundamental challenge in computational pathology. While mainstream approaches often adopt Multiple Instance Learning (MIL), they struggle to capture…

Computer Vision and Pattern Recognition · Computer Science 2025-08-08 Mingxi Fu , Xitong Ling , Yuxuan Chen , Jiawen Li , fanglei fu , Huaitian Yuan , Tian Guan , Yonghong He , Lianghui Zhu

Vision Transformers (ViTs) have ushered in a new era in computer vision, showcasing unparalleled performance in many challenging tasks. However, their practical deployment in computational pathology has largely been constrained by the sheer…

Computer Vision and Pattern Recognition · Computer Science 2023-12-21 Clément Grisi , Geert Litjens , Jeroen van der Laak

Presenting whole slide images (WSIs) as graph will enable a more efficient and accurate learning framework for cancer diagnosis. Due to the fact that a single WSI consists of billions of pixels and there is a lack of vast annotated datasets…

Image and Video Processing · Electrical Eng. & Systems 2023-06-09 Milan Aryal , Nasim Yahyasoltani

In digital pathology, whole slide images (WSIs) are widely used for applications such as cancer diagnosis and prognosis prediction. Visual transformer models have recently emerged as a promising method for encoding large regions of WSIs…

Computer Vision and Pattern Recognition · Computer Science 2023-04-18 Shuai Jiang , Liesbeth Hondelink , Arief A. Suriawinata , Saeed Hassanpour

In computation pathology, the pyramid structure of gigapixel Whole Slide Images (WSIs) has recently been studied for capturing various information from individual cell interactions to tissue microenvironments. This hierarchical structure is…

Computer Vision and Pattern Recognition · Computer Science 2023-09-15 Ziyu Guo , Weiqin Zhao , Shujun Wang , Lequan Yu

Machine learning in computational pathology (CPath) often aggregates patch-level predictions from multi-gigapixel Whole Slide Images (WSIs) to generate WSI-level prediction scores for crucial tasks such as survival prediction and drug…

Machine Learning · Computer Science 2025-12-29 Piotr Keller , Muhammad Dawood , Brinder Singh Chohan , Fayyaz ul Amir Afsar Minhas

Training neural networks with high-quality pixel-level annotation in histopathology whole-slide images (WSI) is an expensive process due to gigapixel resolution of WSIs. However, recent advances in self-supervised learning have shown that…

Image and Video Processing · Electrical Eng. & Systems 2024-05-27 Nohemi Sofia Leon Contreras , Marina D'Amato , Francesco Ciompi , Clement Grisi , Witali Aswolinskiy , Simona Vatrano , Filippo Fraggetta , Iris Nagtegaal

Many image understanding tasks involve identifying what is present and where it appears. However, tasks that address where, such as object discovery, detection, and segmentation, are often considerably more complex than image…

Computer Vision and Pattern Recognition · Computer Science 2026-05-13 Ryota Yoshihashi , Masahiro Kada , Satoshi Ikehata , Rei Kawakami , Ikuro Sato

Histopathological image analysis is an essential process for the discovery of diseases such as cancer. However, it is challenging to train CNN on whole slide images (WSIs) of gigapixel resolution considering the available memory capacity.…

Image and Video Processing · Electrical Eng. & Systems 2019-10-11 Shusuke Takahama , Yusuke Kurose , Yusuke Mukuta , Hiroyuki Abe , Masashi Fukayama , Akihiko Yoshizawa , Masanobu Kitagawa , Tatsuya Harada

Histopathology has played an essential role in cancer diagnosis. With the rapid advances in convolutional neural networks (CNN). Various CNN-based automated pathological image segmentation approaches have been developed in computer-assisted…

Image and Video Processing · Electrical Eng. & Systems 2021-09-23 Cam Nguyen , Zuhayr Asad , Yuankai Huo

Cancer remains one of the leading causes of mortality worldwide, necessitating accurate diagnosis and prognosis. Whole Slide Imaging (WSI) has become an integral part of clinical workflows with advancements in digital pathology. While…

Image and Video Processing · Electrical Eng. & Systems 2025-04-09 Ahmad Hussein , Mukesh Prasad , Ali Anaissi , Ali Braytee

Whole-Slide Imaging allows for the capturing and digitization of high-resolution images of histological specimen. An automated analysis of such images using deep learning models is therefore of high demand. The transformer architecture has…

Computer Vision and Pattern Recognition · Computer Science 2023-05-12 Firas Khader , Jakob Nikolas Kather , Tianyu Han , Sven Nebelung , Christiane Kuhl , Johannes Stegmaier , Daniel Truhn

Automated whole slide image (WSI) tagging has become a growing demand due to the increasing volume and diversity of WSIs collected nowadays in histopathology. Various methods have been studied to classify WSIs with single tags but none of…

Computer Vision and Pattern Recognition · Computer Science 2019-07-05 Weijian Li , Viet-Duy Nguyen , Haofu Liao , Matt Wilder , Ke Cheng , Jiebo Luo

Recently, Transformer architecture has been introduced into image restoration to replace convolution neural network (CNN) with surprising results. Considering the high computational complexity of Transformer with global attention, some…

Computer Vision and Pattern Recognition · Computer Science 2023-03-24 Zheng Chen , Yulun Zhang , Jinjin Gu , Yongbing Zhang , Linghe Kong , Xin Yuan

Computational pathology and whole-slide image (WSI) analysis are pivotal in cancer diagnosis and prognosis. However, the ultra-high resolution of WSIs presents significant modeling challenges. Recent advancements in pathology foundation…

Computer Vision and Pattern Recognition · Computer Science 2025-03-11 Honglin Li , Zhongyi Shui , Yunlong Zhang , Chenglu Zhu , Lin Yang

Most models of visual attention aim at predicting either top-down or bottom-up control, as studied using different visual search and free-viewing tasks. In this paper we propose the Human Attention Transformer (HAT), a single model that…

Computer Vision and Pattern Recognition · Computer Science 2024-04-02 Zhibo Yang , Sounak Mondal , Seoyoung Ahn , Ruoyu Xue , Gregory Zelinsky , Minh Hoai , Dimitris Samaras