Related papers: Optimizing supercontinuum spectro-temporal propert…
Many experiments in biological and medical sciences currently use multiphoton microscopy as a core imaging technique. To date, solid-state lasers are most commonly used as excitation beam sources. However, the most demanding applications…
Multimode fibers (MMFs) have recently reemerged as attractive avenues for nonlinear effects due to their high-dimensional spatiotemporal nonlinear dynamics and scalability for high power. High-brightness MMF sources with effective control…
This thesis centres on the development of multidimensional fluorescence imaging tools, with a particular emphasis on fluorescence lifetime imaging (FLIM) microscopy for application to biological research. The key aspects of this thesis are…
Multiphoton microscopes employ femtosecond lasers as light sources because the high peak power of the ultrashort pulse allows for multiphoton excitation of fluorescence in the examined sample. However, such short pulses are susceptible to…
Numerical simulations are used to study how fiber supercontinuum generation seeded by picosecond pulses can be actively controlled through the use of input pulse modulation. By carrying out multiple simulations in the presence of noise, we…
We show that the modulation of the phases of the laser beams of ultra-short pulses leads to modulation of the two photon fluorescence intensity. The phase modulation technique when used in multi-photon microscopy can improve the signal to…
Spatiotemporal nonlinear interactions in multimode fibers are of interest for beam shaping and frequency conversion by exploiting the nonlinear propagation of different pump regimes from quasi-continuous wave to ultrashort pulses centered…
Multimode optical fibers represent the ideal platform for transferring multidimensional light states. However, dispersion degrades the correlations between the light's degrees of freedom, thus limiting the effective transport of ultrashort…
Supercontinuum generation by femtosecond filaments in air is investigated for different laser wavelengths ranging from ultraviolet to infrared. Particular attention is paid on the role of third-harmonic generation and temporal steepening…
Broadband laser sources based on supercontinuum generation by femtosecond laser filamentation have enabled applications from stand-off sensing and spectroscopy to the generation and self-compression of high-energy few-cycle pulses.…
We report the application of fifth order nonlinear optical processes for multiphoton microscopy, including fifth harmonic and 5-photon excitation fluorescence. This novel imaging modality has been characterized with spectral and power…
Research on multimode optical fibers is arousing a growing interest, for their capability to transport high-power laser beams, coupled with novel nonlinear optics-based applications. However, when beam intensities exceed a certain critical…
Multiphoton microscopy is widely used for live imaging. However, its acquisition speed remains limited by fluorophore emission rates and photodamage. To increase the pixel rate of a two-photon microscope beyond a few megahertz (MHz),…
Nonlinear propagation of intense femtosecond laser pulses in bulk transparent media leads to a specific propagation regime, termed femtosecond filamentation, which in turn produces dramatic spectral broadening, or superbroadening, termed…
Fluorescence microscopy is widely employed for the analysis of living biological samples; however, the utility of the resulting recordings is frequently constrained by noise, temporal variability, and inconsistent visualisation of signals…
A transducer of single photons between microwave and optical frequencies can be used to realize quantum communication over optical fiber links between distant superconducting quantum computers. A promising scalable approach to constructing…
We report the generation of spectrally-tailored supercontinuum using Fourier-domain pulse shaping of femtosecond pulses injected into a highly nonlinear fiber controlled by a genetic algorithm. User-selectable spectral enhancement is…
Multiphoton femtosecond coherent control of is used for implementing innovative photo-induced analog coherent computation that generally might be a basis for future "smart hardware". The specific implemented computational task the…
Nonlinear pulse propagation in multimode fibers (MMFs) offers a compact, low-cost route to broadband, tunable femtosecond light, but most control schemes act by changing the spatial mode composition, typically resulting in irregular or…
Multi-photon microscopy is a powerful tool in biomolecular research. Less complex and more cost effective excitation light sources will make this technique accessible to a broader community. Especially semiconductor diode seeded fiber…