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Diffusion-mediated surface phenomena are crucial for human life and industry, with examples ranging from oxygen capture by lung alveolar surface to heterogeneous catalysis, gene regulation, membrane permeation and filtration processes.…

Statistical Mechanics · Physics 2020-08-19 Denis S. Grebenkov

Many processes in cell biology involve diffusion in a domain $\Omega$ that contains a target $\calU$ whose boundary $\partial \calU$ is a chemically reactive surface. Such a target could represent a single reactive molecule, an…

Statistical Mechanics · Physics 2022-01-06 Paul C. Bressloff

In this paper, we investigate the effects of stochastic resetting on diffusion in $\R^d\backslash \calU$, where $\calU$ is a bounded obstacle with a partially absorbing surface $\partial \calU$. We begin by considering a Robin boundary…

Statistical Mechanics · Physics 2022-06-29 Paul C. Bressloff

We investigate the statistics of encounters of a diffusing particle with different subsets of the boundary of a confining domain. The encounters with each subset are characterized by the boundary local time on that subset. We extend a…

Statistical Mechanics · Physics 2021-10-14 Denis S. Grebenkov

In this paper, we develop an encounter-based model of partial surface adsorption for fractional diffusion in a bounded domain. We take the probability of adsorption to depend on the amount of particle-surface contact time, as specified by a…

Statistical Mechanics · Physics 2023-03-21 Paul C Bressloff

In this paper we develop a hybrid version of the encounter-based approach to diffusion-mediated absorption at a reactive surface, which takes into account stochastic switching of a diffusing particle's conformational state. For simplicity,…

Statistical Mechanics · Physics 2022-09-21 Paul C. Bressloff

In this paper we consider a threshold surface absorption mechanism for a particle diffusing in a domain containing a single target $\calU $. The target boundary $\partial \calU$ is taken to be a reactive surface that modifies an internal…

Statistical Mechanics · Physics 2022-04-12 Paul C. Bressloff

In this paper we extend the encounter-based model of diffusion-mediated surface absorption to the case of an unbiased run-and-tumble particle (RTP) confined to a finite interval $[0,L]$ and switching between two constant velocity states…

Statistical Mechanics · Physics 2022-12-07 Paul C Bressloff

We investigate the statistical correlation between the first-reaction time of a diffusing particle and its boundary local time accumulated until the reaction event. Since the reaction event occurs after multiple encounters of the particle…

Statistical Mechanics · Physics 2026-02-04 Yilin Ye , Denis S. Grebenkov

How long does a diffusing molecule spend in a close vicinity of a confining boundary or a catalytic surface? This quantity is determined by the boundary local time, which plays thus a crucial role in the description of various…

Statistical Mechanics · Physics 2020-01-03 Denis S. Grebenkov

An encounter-based approach consists in using the boundary local time as a proxy for the number of encounters between a diffusing particle and a target to implement various surface reaction mechanisms on that target. In this paper, we…

Statistical Mechanics · Physics 2023-10-03 Ziyad Benkhadaj , Denis S. Grebenkov

A probabilistic framework for studying single-particle diffusion in partially absorbing media has recently been developed in terms of an encounter-based approach. The latter computes the joint probability density (generalized propagator)…

Statistical Mechanics · Physics 2022-10-12 Paul C Bressloff

We revise the encounter-based approach to imperfect diffusion-controlled reactions, which employs the statistics of encounters between a diffusing particle and the reactive region to implement surface reactions. We extend this approach to…

Statistical Mechanics · Physics 2023-10-03 Denis S. Grebenkov

We develop a theory of reversible diffusion-controlled reactions with generalized binding/unbinding kinetics. In this framework, a diffusing particle can bind to the reactive substrate after a random number of arrivals onto it, with a given…

Chemical Physics · Physics 2023-10-03 Denis S. Grebenkov

We develop an encounter-based approach for describing restricted diffusion with a gradient drift towards a partially reactive boundary. For this purpose, we introduce an extension of the Dirichlet-to-Neumann operator and use its eigenbasis…

Chemical Physics · Physics 2022-10-10 Denis S. Grebenkov

Encounter-based models of diffusion provide a probabilistic framework for analyzing the effects of a partially absorbing reactive surface, in which the probability of absorption depends upon the amount of surface-particle contact time.…

Statistical Mechanics · Physics 2023-07-05 Paul C Bressloff

A general topic of current interest is the analysis of diffusion problems in singularly perturbed domains with small interior targets or traps (the narrow capture problem). One major application is to intracellular diffusion, where the…

Statistical Mechanics · Physics 2022-04-13 Paul C. Bressloff

The adsorption phenomenon of neutral particles from the limiting surfaces of the sample in the Langmuir approximation is investigated. The diffusion equation regulating the redistribution of particles in the bulk is assumed to be of…

Mathematical Physics · Physics 2014-02-13 A Sapora , M Codegone , G Barbero , LR Evangelista

Dynamics of a particle diffusing in a confinement can be seen a sequence of bulk-diffusion-mediated hops on the confinement surface. Here, we investigate the surface hopping propagator that describes the position of the diffusing particle…

Statistical Mechanics · Physics 2020-09-23 Denis S. Grebenkov

We derive, through subordination techniques, a generalized Feynman-Kac equation in the form of a time fractional Schrodinger equation. We relate such equation to a functional which we name the subordinated local time. We demonstrate through…

Statistical Mechanics · Physics 2023-05-01 Toby Kay , Luca Giuggioli
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