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Evolutionary algorithms have long been used for optimization problems where the appropriate size of solutions is unclear a priori. The applicability of this methodology is here investigated on the problem of designing a nano-particle (NP)…

Neural and Evolutionary Computing · Computer Science 2020-11-11 Michail-Antisthenis Tsompanas , Larry Bull , Andrew Adamatzky , Igor Balaz

The choice of parameters, and the design of the network architecture are important factors affecting the performance of deep neural networks. Genetic Algorithms (GA) have been used before to determine parameters of a network. Yet, GAs…

Computer Vision and Pattern Recognition · Computer Science 2018-09-28 Yantao Lu , Burak Kakillioglu , Senem Velipasalar

Efficient design of genomic perturbation experiments is crucial for accelerating drug discovery and therapeutic target identification, yet exhaustive perturbation of the human genome remains infeasible due to the vast search space of…

Machine Learning · Statistics 2026-03-24 Yanke Li , Tianyu Cui , Tommaso Mansi , Mangal Prakash , Rui Liao

Intensity modulated proton therapy (IMPT) provides highly conformal dose distributions through the application of multiple, angularly spaced fields, each applying an ad-hoc pattern of spatially varying particle fluences. In particular,…

Medical Physics · Physics 2017-03-10 F. Arcadu

Optical focusing through scattering media has important implications for optical applications in medicine, communications, and detection. In recent years, many wavefront shaping methods have been successfully applied to the field, among…

A split feasibility formulation for the inverse problem of intensity-modulated radiation therapy (IMRT) treatment planning with dose-volume constraints (DVCs) included in the planning algorithm is presented. It involves a new type of…

Medical Physics · Physics 2017-04-26 S. Penfold , R. Zalas , M. Casiraghi , M. Brooke , Y. Censor , R. Schulte

The evolution of gene regulatory networks in variable environments poses Multi-objective Optimization Problem (MOP), where the expression levels of genes must be tuned to meet the demands of each environment. When formalized in the context…

Optimization and Control · Mathematics 2018-04-23 Philippe Nghe , Bela M. Mulder , Sander J. Tans

Targeted therapies on the basis of genomic aberrations analysis of the tumor have shown promising results in cancer prognosis and treatment. Regardless of tumor type, trials that match patients to targeted therapies for their particular…

Applications · Statistics 2018-04-18 Yanxun Xu , Peter Mueller , Apostolia M Tsimberidou , Donald Berry

One of the main limitations of utilizing optimal wavefront shaping in imaging and authentication applications is the slow speed of the optimization algorithms currently being used. To address this problem we develop a micro-genetic…

In this paper, we present a novel approach to accelerate the Bayesian inference process, focusing specifically on the nested sampling algorithms. Bayesian inference plays a crucial role in cosmological parameter estimation, providing a…

Instrumentation and Methods for Astrophysics · Physics 2024-10-17 Isidro Gómez-Vargas , J. Alberto Vázquez

We present for the first time a general 6DoF trajectory planning method that can be used in real-time image guided radiation therapy procedures for robotic stabilization of dynamically moving tumor targets. As the radiation beam is always…

Medical Physics · Physics 2018-08-14 Rodney D. Wiersma , Xinmin Liu

We propose a novel optimization model for volumetric modulated arc therapy (VMAT) planning that directly optimizes deliverable leaf trajectories in the treatment plan optimization problem, and eliminates the need for a separate…

Medical Physics · Physics 2014-03-05 Dávid Papp , Jan Unkelbach

Background: Beam angle optimization (BAO) is a critical component of radiation therapy (RT) treatment planning, where small changes in beam configuration can significantly impact treatment quality, especially for proton RT. Mathematically,…

Medical Physics · Physics 2025-09-08 Nimita Shinde , Ya-Nan Zhu , Haozheng Shen , Hao Gao

Robust optimization is a commonly employed method to mitigate uncertainties in the planning of intensity-modulated proton therapy (IMPT). In certain contexts, the large number of uncertainty scenarios makes the robust problem impractically…

Medical Physics · Physics 2025-04-22 Ivar Bengtsson

Genetic algorithms, computer programs that simulate natural evolution, are increasingly applied across many disciplines. They have been used to solve various optimisation problems from neural network architecture search to strategic games,…

Neural and Evolutionary Computing · Computer Science 2021-09-14 Aymeric Vie , Alissa M. Kleinnijenhuis , Doyne J. Farmer

State selective field ionization detection techniques in physics require a specific progression through a complicated atomic state space to optimize state selectivity and overall efficiency. For large principle quantum number n, the…

Instrumentation and Detectors · Physics 2010-10-28 M. L. Jones , B. Sanguinetti , H. O. Majeed , B. T. H. Varcoe

We wish to minimize the resources used for network coding while achieving the desired throughput in a multicast scenario. We employ evolutionary approaches, based on a genetic algorithm, that avoid the computational complexity that makes…

Networking and Internet Architecture · Computer Science 2016-11-15 Minkyu Kim , Muriel Medard , Varun Aggarwal , Una-May O'Reilly , Wonsik Kim , Chang Wook Ahn , Michelle Effros

Optimization problems aim to find the optimal solution, which is becoming increasingly complex and difficult to solve. Traditional evolutionary optimization methods always overlook the granular characteristics of solution space. In the real…

Machine Learning · Computer Science 2025-02-19 Shuyin Xia , Xinyu Lin , Guan Wang , De-Gang Chen , Sen Zhao , Guoyin Wang , Jing Liang

A novel simulation strategy is proposed to search for semiconductor quantum devices which are optimized with respect to required performances. Based on evolutionary programming, a tecnique implementing the paradigm of genetic algorithms to…

Materials Science · Physics 2009-10-31 Guido Goldoni , Fausto Rossi

The paper represents an algorithm for planning safe and optimal routes for transport facilities with unrestricted movement direction that travel within areas with obstacles. Paper explains the algorithm using a ship as an example of such a…

Neural and Evolutionary Computing · Computer Science 2019-05-15 Ivan Yanchin , Oleg Petrov
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