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Objectives: Pancreatic cancer is a lethal disease, hard to diagnose and usually results in poor prognosis and high mortality. Developing an artificial intelligence (AI) algorithm to accurately and universally predict the early cancer risk…

Uterine leiomyosarcoma (LMS) is a rare but aggressive malignancy. On imaging, it is difficult to differentiate LMS from, for example, degenerated leiomyoma (LM), a prevalent but benign condition. We curated a data set of 115 axial…

Tumor shape plays a critical role in influencing both growth and metastasis. We introduce a novel topological radiomic feature derived from persistent homology to characterize tumor shape, focusing on its association with time-to-event…

Methodology · Statistics 2025-12-08 Yuhyeong Jang , Tu Dan , Eric Vu , Chul Moon

With nearly one million new cases diagnosed worldwide in 2020, head \& neck cancer is a deadly and common malignity. There are challenges to decision making and treatment of such cancer, due to lesions in multiple locations and outcome…

Image and Video Processing · Electrical Eng. & Systems 2023-05-17 Angel Victor Juanco Muller , Joao F. C. Mota , Keith A. Goatman , Corne Hoogendoorn

Cancers are the leading cause of death in many countries. Early diagnosis plays a crucial role in having proper treatment for this debilitating disease. The automated classification of the type of cancer is a challenging task since…

Image and Video Processing · Electrical Eng. & Systems 2021-08-20 Hosein Barzekar , Zeyun Yu

Quantitative medical image computing (radiomics) has been widely applied to build prediction models from medical images. However, overfitting is a significant issue in conventional radiomics, where a large number of radiomic features are…

Image and Video Processing · Electrical Eng. & Systems 2020-01-07 Jianan Chen , Laurent Milot , Helen M. C. Cheung , Anne L. Martel

Routine computed tomography (CT) scans often detect a wide range of renal cysts, some of which may be malignant. Early and precise localization of these cysts can significantly aid quantitative image analysis. Current segmentation methods,…

Recent advances in molecular and genetic research have identified a diverse range of brain tumor sub-types, shedding light on differences in their molecular mechanisms, heterogeneity, and origins. The present study performs whole-brain…

Neurons and Cognition · Quantitative Biology 2024-07-26 Debanjali Bhattacharya , Ninad Aithal , Manish Jayswal , Neelam Sinha

Gliomas are brain tumours with a high mortality rate. There are various grades and sub-types of this tumour, and the treatment procedure varies accordingly. Clinicians and oncologists diagnose and categorise these tumours based on visual…

Image and Video Processing · Electrical Eng. & Systems 2020-11-12 Azam Hamidinekoo , Tomasz Pieciak , Maryam Afzali , Otar Akanyeti , Yinyin Yuan

Robust and generalizable segmentation of brain tumors on multi-parametric magnetic resonance imaging (MRI) remains difficult because tumor types differ widely. The BraTS 2025 Lighthouse Challenge benchmarks segmentation methods on diverse…

Locoregional recurrences (LRR) are still a frequent site of treatment failure for head and neck squamous cell carcinoma (HNSCC) patients. Identification of high risk subvolumes based on pretreatment imaging is key to biologically targeted…

Objective: Lung cancer is the leading cause of cancer-related death worldwide. Computer-aided diagnosis (CAD) systems have shown significant promise in recent years for facilitating the effective detection and classification of abnormal…

Computer Vision and Pattern Recognition · Computer Science 2019-01-16 Vignesh Sankar , Devinder Kumar , David A. Clausi , Graham W. Taylor , Alexander Wong

Identifying image features that are robust with respect to segmentation variability and domain shift is a tough challenge in radiomics. So far, this problem has mainly been tackled in test-retest analyses. In this work we analyze radiomics…

Image and Video Processing · Electrical Eng. & Systems 2020-01-22 Christoph Haarburger , Justus Schock , Daniel Truhn , Philippe Weitz , Gustav Mueller-Franzes , Leon Weninger , Dorit Merhof

Purpose: to optimize a pipeline of clinical data gathering and CT images processing implemented during the COVID-19 pandemic crisis and to develop artificial intelligence model for different of viral pneumonia. Methods: 1028 chest CT image…

Medical Physics · Physics 2021-09-30 Giulia Zorzi , Luca Berta , Stefano Carrazza , Alberto Torresin

Accurate segmentation of Anatomical brain Barriers to Cancer spread (ABCs) plays an important role for automatic delineation of Clinical Target Volume (CTV) of brain tumors in radiotherapy. Despite that variants of U-Net are…

Image and Video Processing · Electrical Eng. & Systems 2022-06-08 Hao Fu , Guotai Wang , Wenhui Lei , Wei Xu , Qianfei Zhao , Shichuan Zhang , Kang Li , Shaoting Zhang

Artificial Intelligence (AI) can potentially support histopathologists in the diagnosis of a broad spectrum of cancer types. In colorectal cancer (CRC), AI can alleviate the laborious task of characterization and reporting on resected…

Image and Video Processing · Electrical Eng. & Systems 2023-02-10 John-Melle Bokhorst , Iris D. Nagtegaal , Filippo Fraggetta , Simona Vatrano , Wilma Mesker , Michael Vieth , Jeroen van der Laak , Francesco Ciompi

Purpose: Radiotherapy commonly relies on CT, but there is growing interest in using hybrid PET/MR. Therefore, dedicated hardware setups have been proposed for PET/MR systems which enable imaging in radiotherapy treatment position. These…

Medical Physics · Physics 2024-11-14 R. M. Winter , O. Engelsen , O. J. Bratting , N. Brekke , J. Sæterstøl , O. Sæther , K. R. Redalen

We predict mechanical ventilation requirement and mortality using computational modeling of chest radiographs (CXRs) for coronavirus disease 2019 (COVID-19) patients. This two-center, retrospective study analyzed 530 deidentified CXRs from…

Background and Purpose: Biopsy is the main determinants of glioma clinical management, but require invasive sampling that fail to detect relevant features because of tumor heterogeneity. The purpose of this study was to evaluate the…

Quantitative Methods · Quantitative Biology 2019-08-08 Emily E Diller , Sha Cao , Beth Ey , Robert Lober , Jason G Parker

While colorectal liver metastasis (CRLM) is potentially curable via hepatectomy, patient outcomes remain highly heterogeneous. Postoperative survival prediction is necessary to avoid non-beneficial surgeries and guide personalized therapy.…

Computer Vision and Pattern Recognition · Computer Science 2026-03-12 Muhammad Alberb , Jianan Chen , Hossam El-rewaidy , Paul Karanicolas , Arun Seth , Yutaka Amemiya , Anne Martel , Helen Cheung
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