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The trade-off between throughput and image quality is an inherent challenge in microscopy. To improve throughput, compressive imaging under-samples image signals; the images are then computationally reconstructed by solving a regularized…

Image and Video Processing · Electrical Eng. & Systems 2023-03-07 Udith Haputhanthri , Andrew Seeber , Dushan Wadduwage

We discuss recently emerging applications of the state-of-art deep learning methods on optical microscopy and microscopic image reconstruction, which enable new transformations among different modes and modalities of microscopic imaging,…

Machine Learning · Computer Science 2018-07-23 Yair Rivenson , Aydogan Ozcan

Prototype optical microscopes, built to pursue developments in advanced imaging techniques, need specific optomechanical constructions: preferably with high flexibility in the elements arrangement, easy access to the optical paths,…

Instrumentation and Detectors · Physics 2023-05-30 Łukasz Zinkiewicz , Milena Królikowska , Alexander Krupiński-Ptaszek , Piotr Wasylczyk

Optical imaging technologies are central to discovery in the life and physical sciences, yet their impact depends on how readily they can be built, adapted, and sustained across laboratories. Digital fabrication, including desktop 3D…

Most camera lens systems are designed in isolation, separately from downstream computer vision methods. Recently, joint optimization approaches that design lenses alongside other components of the image acquisition and processing pipeline…

Computer Vision and Pattern Recognition · Computer Science 2023-03-29 Geoffroi Côté , Fahim Mannan , Simon Thibault , Jean-François Lalonde , Felix Heide

Ultrathin meta-optics offer unmatched, multifunctional control of light. Next-generation optical technologies, however, demand unprecedented performance. This will likely require design algorithms surpassing the capability of human…

Optics · Physics 2021-04-06 Shane Colburn , Arka Majumdar

Phase retrieval in optical imaging refers to the recovery of a complex signal from phaseless data acquired in the form of its diffraction patterns. These patterns are acquired through a system with a coherent light source that employs a…

Coded-illumination can enable quantitative phase microscopy of transparent samples with minimal hardware requirements. Intensity images are captured with different source patterns and a non-linear phase retrieval optimization reconstructs…

Signal Processing · Electrical Eng. & Systems 2019-02-07 Michael R. Kellman , Emrah Bostan , Nicole Repina , Laura Waller

Differentiable optics, as an emerging paradigm that jointly optimizes optics and (optional) image processing algorithms, has made innovative optical designs possible across a broad range of applications. Many of these systems utilize…

Phase retrieval is a nonlinear inverse problem that arises in a wide range of imaging modalities, from electron microscopy to Fourier ptychography. In particular, the reconstruction is facilitated when the sensing matrix is i.i.d. random,…

Optical microscopy is an indispensable tool in life sciences research, but conventional techniques require compromises between imaging parameters like speed, resolution, field-of-view, and phototoxicity. To overcome these limitations,…

Quantitative Methods · Quantitative Biology 2024-04-01 Leonor Morgado , Estibaliz Gómez-de-Mariscal , Hannah S. Heil , Ricardo Henriques

The design of astronomical hardware operating at the diffraction limit requires optimisation of physical optical simulations of the instrument with respect to desired figures of merit, such as photometric or astrometric precision. System…

Instrumentation and Methods for Astrophysics · Physics 2026-04-02 Louis Desdoigts , Benjamin Pope , Michael Gully-Santiago , Peter Tuthill

This review article provides a contemporary overview of phase retrieval in optical imaging, linking the relevant optical physics to the information processing methods and algorithms. Its purpose is to describe the current state of the art…

Information Theory · Computer Science 2014-03-03 Yoav Shechtman , Yonina C. Eldar , Oren Cohen , Henry N. Chapman , Jianwei Miao , Mordechai Segev

Phase is a fundamental resource for optical imaging but cannot be directly observed with intensity measurements. The existing methods to quantify a phase distribution rely on complex devices and structures. Here we experimentally…

Optics · Physics 2020-03-25 Tengfeng Zhu , Junyi Huang , Zhichao Ruan

Fourier Ptychographic Microscopy (FPM) is a computational imaging method that is able to super-resolve features beyond the diffraction-limit set by the objective lens of a traditional microscope. This is accomplished by using synthetic…

Signal Processing · Electrical Eng. & Systems 2019-04-09 Michael Kellman , Emrah Bostan , Michael Chen , Laura Waller

The principal limitation in many areas of astronomy, especially for directly imaging exoplanets, arises from instability in the point spread function (PSF) delivered by the telescope and instrument. To understand the transfer function, it…

Instrumentation and Methods for Astrophysics · Physics 2021-09-01 Alison Wong , Benjamin Pope , Louis Desdoigts , Peter Tuthill , Barnaby Norris , Chris Betters

Smart microscopy represents a paradigm shift in biological imaging, moving from passive observation tools to active collaborators in scientific inquiry. Enabled by advances in automation, computational power, and artificial intelligence,…

Artificial Intelligence · Computer Science 2025-05-28 P. S. Kesavan , Pontus Nordenfelt

Deep optics has emerged as a promising approach by co-designing optical elements with deep learning algorithms. However, current research typically overlooks the analysis and optimization of manufacturing and assembly tolerances. This…

Computer Vision and Pattern Recognition · Computer Science 2025-02-10 Jun Dai , Liqun Chen , Xinge Yang , Yuyao Hu , Jinwei Gu , Tianfan Xue

Computational imaging systems jointly design computation and hardware to retrieve information which is not traditionally accessible with standard imaging systems. Recently, critical aspects such as experimental design and image priors are…

Image and Video Processing · Electrical Eng. & Systems 2020-03-13 Michael Kellman , Jon Tamir , Emrah Boston , Michael Lustig , Laura Waller

Inserting a patterned occluder at the aperture of a camera lens has been shown to improve the recovery of depth map and all-focus image compared to a fully open aperture. However, design of the aperture pattern plays a very critical role.…

Computer Vision and Pattern Recognition · Computer Science 2017-06-02 Prasan A Shedligeri , Sreyas Mohan , Kaushik Mitra
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