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The infrared beamline at BESSY II storage ring was upgraded recently to extend capabilities of infrared microscopy. The end-stations available at the beamline are now facilitating improved characterization of molecules and materials at…

Optics · Physics 2024-05-09 Alexander Veber , Ljiljana Puskar , Janina Kneipp , Ulrich Schade

Atomic Force Microscopy - Infrared (AFM-IR) spectroscopy allows spectroscopic studies in the mid-infrared spectral region with a spatial resolution better than 50 nm. We show that the high spatial resolution can be used to perform…

Quantitative Methods · Quantitative Biology 2017-04-06 Luca Quaroni , Katarzyna Pogoda , Joanna-Wiltowska Zuber , Wojciech Kwiatek

This comprehensive review discusses the development of scanning electron microscopy and the application of this technology in different fields such as biology, nanobiotechnology and biomedical science. Besides being a tool for high…

Quantitative Methods · Quantitative Biology 2023-11-02 Aniruddha Acharya

Conventional biomedical imaging modalities, including endoscopy, X-rays, and magnetic resonance, are invasive and cannot provide sufficient spatial and temporal resolutions for regular imaging of gastrointestinal (GI) tract to guide…

Spatial mapping of thermal properties is critical for unveiling the structure-property relation of materials, heterogeneous interfaces, and devices. These property images can also serve as datasets for training artificial intelligence…

Applied Physics · Physics 2025-07-18 Haobo Yang , Zhenguo Zhu , Zhongnan Xie , Jinhong Du , Shuo Bai , Hong Guo , Te-Huan Liu , Ronggui Yang , Xin Qian

Rapid, comprehensive, and accurate cell phenotyping without compromising viability, is crucial to many important biomedical applications, including stem-cell therapy, drug screening, and liquid biopsy. Typical image cytometry methods…

This work proposes an innovative approach to improve Bragg coherent diffraction imaging (BCDI) microscopy applied to time evolving crystals and/or non-homogeneous crystalline strain fields, identified as two major limitations of BCDI…

Optics · Physics 2024-03-12 I. Calvo-Almazán , V. Chamard , T. Grünewald , M. Allain

Imaging in thick biological tissues is often degraded by sample-induced aberrations, which reduce image quality and resolution, particularly in super-resolution techniques. While hardware-based adaptive optics, which correct aberrations…

Dual-comb spectroscopy has been proven a powerful tool in molecular characterization, which remains challenging to implement in the mid-infrared region due to difficulties in the realization of two mutually locked comb sources and efficient…

We present a Bayesian framework to establish a power-spectrum space decomposition of frequency tomographic (PSDFT) data for future intensity mapping (IM) experiments. Different from most traditional component-separation methods which work…

Instrumentation and Methods for Astrophysics · Physics 2023-08-30 Chang Feng , Filipe B. Abdalla

Light-field imaging is an emerging paradigm in biomedical optics, offering the unique ability to capture volumetric information in a single snapshot by encoding both the spatial and angular components of light. Unlike conventional…

Optics · Physics 2025-09-30 Ruixuan Zhao , Xuanwen Hua , Woongjae Baek , Zhaoqiang Wang , Shu Jia , Liang Gao

The Infra-Red Imaging Spectrograph (IRIS) is one of the three first light instruments for the Thirty Meter Telescope (TMT) and is the only one to directly sample the diffraction limit. The instrument consists of a parallel imager and…

Instrumentation and Methods for Astrophysics · Physics 2015-05-19 Anna M. Moore , Brian J. Bauman , Elizabeth J. Barton , David Crampton , Alex Delacroix , James E. Larkin , Luc Simard , Ryuji Suzuki , Shelley A. Wright

We propose a new strategy for narrow band, active array imaging of localized scat- terers when only the intensities are recorded and measured at the array. We consider a homogeneous medium so that wave propagation is fully coherent. We show…

Optimization and Control · Mathematics 2014-11-12 Alexei Novikov , Miguel Moscoso , George Papanicolaou

The widespread deployment of Infrared Small-Target Detection (IRSTD) algorithms on edge devices necessitates the exploration of model compression techniques. Binarized neural networks (BNNs) are distinguished by their exceptional efficiency…

Computer Vision and Pattern Recognition · Computer Science 2025-08-05 Biqiao Xin , Qianchen Mao , Bingshu Wang , Jiangbin Zheng , Yong Zhao , C. L. Philip Chen

Mid-infrared spectrum is a critical tool for chemical analysis, industrial inspection, environment, and other fields due to its rich chemical bond information. However, the complicated growth or fabrication procedures of existing…

We present a novel approach to implement compressive sensing in laser scanning microscopes (LSM), specifically in image scanning microscopy (ISM), using a single-photon avalanche diode (SPAD) array detector. Our method addresses two…

Image and Video Processing · Electrical Eng. & Systems 2023-07-20 Ajay Gunalan , Marco Castello , Simonluca Piazza , Shunlei Li , Alberto Diaspro , Leonardo S. Mattos , Paolo Bianchini

An accurate treatment of electronic spectra in large systems with a technique such as time dependent density functional theory (TDDFT) is computationally challenging. Due to the Nyquist sampling theorem, direct real time simulations must be…

Materials Science · Physics 2024-01-17 Matthias Kick , Ezra Alexander , Anton Beiersdorfer , Troy Van Voorhis

Modern imaging techniques at the molecular scale rely on utilizing novel coherent light sources like X-ray free electron lasers for the ultimate goal of visualizing such objects as individual biomolecules rather than crystals. Here, unlike…

The still unmet ability of following the fate of specific cells or molecules within the whole body would give an outstanding breakthrough in the comprehension of disease mechanisms and in the monitoring of therapeutic approaches. Our idea…

Recent advances in photon detectors have resulted in high-density imaging arrays that offer many performance and cost advantages. In particular, the excellent transit time spread of certain devices show promise to provide tangible benefits…

Instrumentation and Detectors · Physics 2009-04-17 Gary S. Varner , Larry L. Ruckman
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