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Strongly coupled immersed boundary (IB) methods solve the nonlinear fluid and structural equations of motion simultaneously for strongly enforcing the no-slip constraint on the body. Handling this constraint requires solving several large…

Fluid Dynamics · Physics 2021-03-12 Nirmal Jayaprasad Nair , Andres Goza

Identifying minimum-energy paths (MEPs) is crucial for understanding chemical reaction mechanisms but remains computationally demanding. We introduce MEPIN, a scalable machine-learning method for efficiently predicting MEPs from reactant…

Chemical Physics · Physics 2026-02-18 Juno Nam , Miguel Steiner , Max Misterka , Soojung Yang , Avni Singhal , Rafael Gómez-Bombarelli

We define the projected entropy S(T) at a given temperature T in the context of an Ising model transition matrix calculation as the entropy associated with the distribution of Markov chain realizations in energy-magnetization, E-H, space.…

Statistical Mechanics · Physics 2018-10-17 David Yevick

We introduce two synthetic likelihood methods for Simulation-Based Inference (SBI), to conduct either amortized or targeted inference from experimental observations when a high-fidelity simulator is available. Both methods learn a…

Machine Learning · Computer Science 2023-04-19 Pierre Glaser , Michael Arbel , Samo Hromadka , Arnaud Doucet , Arthur Gretton

Even though thermodynamic energy-based crystal structure prediction (CSP) has revolutionized materials discovery, the energy-driven CSP approaches often struggle to identify experimentally realizable metastable materials synthesized through…

Materials Science · Physics 2025-05-15 Yu Xin , Peng Liu , Zhuohang Xie , Wenhui Mi , Pengyue Gao , Hong Jian Zhao , Jian Lv , Yanchao Wang , Yanming Ma

How does the information flow between different brain regions during various stimuli? This is the question we aim to address by studying complex cognitive paradigms in terms of Information Theory. To assess creativity and the emergence of…

Neurons and Cognition · Quantitative Biology 2025-07-08 Ania Mesa-Rodríguez , Ernesto Estevez-Rams , Holger Kantz

In this work, we consider the numerical estimation of the probability for a stochastic process to hit a set B before reaching another set A. This event is assumed to be rare. We consider reactive trajectories of the stochastic Allen-Cahn…

Analysis of PDEs · Mathematics 2019-10-21 Charles-Edouard Bréhier , Maxime Gazeau , Ludovic Goudenège , Mathias Rousset

Agentic language models compose multi step reasoning chains, yet intermediate steps can be corrupted by inconsistent context, retrieval errors, or adversarial inputs, which makes post hoc evaluation too late because errors propagate before…

Machine Learning · Computer Science 2025-11-11 Valentin Noël

Accurate and scalable machine-learned inter-atomic potentials (MLIPs) are essential for molecular simulations ranging from drug discovery to new material design. Current state-of-the-art models enforce roto-translational symmetries through…

This paper addresses the problem of asymptotic tracking for high-order control-affine MIMO nonlinear systems with unknown dynamic terms subject to input and transient state constraints. We introduce Barrier Integral Control (BRIC), a novel…

Systems and Control · Electrical Eng. & Systems 2026-01-21 Christos K. Verginis

We explore the electronic entropy per particle $s$ and Seebeck coefficient $\mathcal{S}$ in zigzag graphene ribbons. Pristine and edge-doped ribbons are considered using tight-binding models to inspect the role of edge states in the…

Mesoscale and Nanoscale Physics · Physics 2023-03-08 Natalia Cortés , Patricio Vargas , S. E. Ulloa

Many quantum phases, from topological orders to superfluids, are destabilized at finite temperature by the proliferation and motion of topological defects such as anyons or vortices. Conventional protection mechanisms rely on energetic gaps…

Quantum Physics · Physics 2026-04-23 Yi-Lin Tsao , Zhu-Xi Luo

The information bottleneck (IB) method is a technique designed to extract meaningful information related to one random variable from another random variable, and has found extensive applications in machine learning problems. In this paper,…

Information Theory · Computer Science 2025-07-29 Lingyi Chen , Shitong Wu , Sicheng Xu , Huihui Wu , Wenyi Zhang

Transition states and minimum energy paths are essential to understand and predict chemical reactivity. Double-ended methods represent a standard approach for their determination. We introduce a new double-ended method that optimizes…

Chemical Physics · Physics 2020-02-18 Alain C. Vaucher , Markus Reiher

In this study, we introduce a training protocol for developing machine learning force fields (MLFFs), capable of accurately determining energy barriers in catalytic reaction pathways. The protocol is validated on the extensively explored…

Chemical Physics · Physics 2023-08-23 Lars Schaaf , Edvin Fako , Sandip De , Ansgar Schäfer , Gábor Csányi

Information entropic measures such as Fisher information, Shannon entropy, Onicescu energy and Onicescu Shannon entropy of a symmetric double-well potential are calculated in both position and momentum space. Eigenvalues and eigenvectors of…

Quantum Physics · Physics 2019-04-26 Neetik Mukherjee , Arunesh Roy , Amlan K. Roy

Kinetic proofreading mechanisms explain the extraordinary accuracy observed in central biological events in terms of the enhanced specificity of substrate selection networks under a nonequilibrium environment. The nonequilibrium steady…

Adaptation and Self-Organizing Systems · Physics 2022-06-29 Premashis Kumar , Kinshuk Banerjee , Gautam Gangopadhyay

We translate the problem of calculating the entropy of a set of binary configurations/signals into a sequence of supervised classification tasks. Subsequently, one can use virtually any machine learning classification algorithm for…

Statistical Mechanics · Physics 2019-10-25 Romuald A. Janik

A kink-based path integral method, previously applied to atomic systems, is modified and used to study molecular systems. The method allows the simultaneous evolution of atomic and electronic degrees of freedom. Results for CH$_4 $, NH$_3…

Chemical Physics · Physics 2009-11-11 Randall W. Hall

In this work, we propose a multi-scale protocol for routine theoretical studies of chemical reaction mechanisms. The initial reaction paths of our investigated systems are sampled using the Nudged-Elastic Band (NEB) method driven by a cheap…

Chemical Physics · Physics 2023-07-26 Tomislav Piskor , Peter Pinski , Thilo Mast , Vladimir V. Rybkin
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