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The first and maybe the most important step in designing a model-based predictive controller is to develop a model that is as accurate as possible and that is valid under a wide range of operating conditions. The sugar boiling process is a…

Chemical Physics · Physics 2012-12-24 Alfred Jean Philippe Lauret , Harry Boyer , Jean Claude Gatina

We develop a new model of insulin-glucose dynamics for forecasting blood glucose in type 1 diabetics. We augment an existing biomedical model by introducing time-varying dynamics driven by a machine learning sequence model. Our model…

Machine Learning · Statistics 2020-08-10 Andrew C. Miller , Nicholas J. Foti , Emily Fox

Background: Accurate week-ahead forecasts of continuous glucose monitoring (CGM) derived metrics could enable proactive diabetes management, but relative performance of modern tabular learning approaches is incompletely defined. Methods: We…

Other Quantitative Biology · Quantitative Biology 2026-01-05 Simon Lebech Cichosz , Stine Hangaard , Thomas Kronborg , Peter Vestergaard , Morten Hasselstrøm Jensen

Many practical applications of optimal control are subject to real-time computational constraints. When applying model predictive control (MPC) in these settings, respecting timing constraints is achieved by limiting the number of…

Optimization and Control · Mathematics 2024-12-16 Anusha Srikanthan , Aren Karapetyan , Vijay Kumar , Nikolai Matni

Achieving global optimality in nonlinear model predictive control (NMPC) is challenging due to the non-convex nature of the underlying optimization problem. Since commonly employed local optimization techniques depend on carefully chosen…

Systems and Control · Electrical Eng. & Systems 2025-06-19 Tzu-Yuan Huang , Armin Lederer , Nicolas Hoischen , Jan Brüdigam , Xuehua Xiao , Stefan Sosnowski , Sandra Hirche

Real-time model predictive control of non-smooth switching systems remains challenging due to discontinuities and the presence of discrete modes, which complicate numerical integration and optimization. This paper presents a real-time…

Systems and Control · Electrical Eng. & Systems 2025-12-11 Hendrik Alsmeier , Felix Häusser , Andreas Knödler , Armin Nurkanović , Anton Pozharskiy , Moritz Diehl , Rolf Findeisen

This paper presents a distributed model predictive control (DMPC) scheme for nonlinear continuous-time systems. The underlying distributed optimal control problem is cooperatively solved in parallel via a sensitivity-based algorithm. The…

Optimization and Control · Mathematics 2024-06-06 Maximilian Pierer von Esch , Andreas Völz , Knut Graichen

Diabetes mellitus affects over 537 million adults worldwide. Insulin-dependent patients require continuous glucose monitoring and precise dose calculation while operating under strict power budgets on wearable devices. This paper presents…

Machine Learning · Computer Science 2026-03-31 Sahil Shrivastava

With advanced data analytical techniques, efforts for more accurate decision support systems for disease prediction are on rise. Surveys by World Health Organization (WHO) indicate a great increase in number of diabetic patients and related…

Machine Learning · Computer Science 2017-06-27 Maham Jahangir , Hammad Afzal , Mehreen Ahmed , Khawar Khurshid , Raheel Nawaz

This research paper compares two neural-network-based adaptive controllers, namely the Hybrid Deep Learning Neural Network Controller (HDLNNC) and the Adaptive Model Predictive Control with Nonlinear Prediction and Linearization along the…

Systems and Control · Electrical Eng. & Systems 2023-04-27 Bartłomiej Guś , Jakub Możaryn

This paper focuses on the trajectory tracking control problem for an articulated unmanned ground vehicle. We propose and compare two approaches in terms of performance and computational complexity. The first uses a nonlinear mathematical…

Systems and Control · Electrical Eng. & Systems 2021-03-26 Erkan Kayacan , Wouter Saeys , Herman Ramon , Calin Belta , Joshua M. Peschel

Heavy-duty hydraulic manipulators (HHMs) operate under strict physical and safety-critical constraints due to their large size, high power, and complex nonlinear dynamics. Ensuring that both joint-level and end-effector trajectories remain…

Robotics · Computer Science 2025-10-28 Alvaro Paz , Mahdi Hejrati , Pauli Mustalahti , Jouni Mattila

Model predictive control (MPC) is a method to formulate the optimal scheduling problem for grid flexibilities in a mathematical manner. The resulting time-constrained optimization problem can be re-solved in each optimization time step…

Systems and Control · Electrical Eng. & Systems 2021-08-20 Steven de Jongh , Sina Steinle , Anna Hlawatsch , Felicitas Mueller , Michael Suriyah , Thomas Leibfried

This work investigates the use of digital twins for dynamical system modeling and control, integrating physics-based, data-driven, and hybrid approaches with both traditional and AI-driven controllers. Using a miniature greenhouse as a test…

Artificial Intelligence · Computer Science 2025-10-29 Adil Rasheed , Oscar Ravik , Omer San

Temperature control is a complex task due to its often unknown dynamics and disturbances. This paper explores the use of Neural Nonlinear AutoRegressive eXogenous (NNARX) models for nonlinear system identification and model predictive…

Systems and Control · Electrical Eng. & Systems 2024-02-09 Jing Xie , Léo Simpson , Jonas Asprion , Riccardo Scattolini

This paper addresses the problem of decentralized tube-based nonlinear Model Predictive Control (NMPC) for a class of uncertain nonlinear continuous-time multi-agent systems with additive and bounded disturbance. In particular, the problem…

Systems and Control · Computer Science 2019-09-05 Alexandros Nikou , Dimos V. Dimarogonas

In this paper we develop a multiple model reference adaptive controller (MMRAC) with blending. The systems under consideration are non-square, i.e., the number of inputs is not equal to the number of states; multi-input, linear,…

Systems and Control · Electrical Eng. & Systems 2024-03-28 Alex Lovi , Baris Fidan , Christopher Nielsen

According to the American Diabetes Association(ADA), 30.3 million people in the United States have diabetes, but only 7.2 million may be undiagnosed and unaware of their condition. Type 2 diabetes is usually diagnosed for most patients…

Machine Learning · Computer Science 2019-10-22 Ramya Akula , Ni Nguyen , Ivan Garibay

We consider two approaches to modelling of cell metabolism of 6-mercaptopurine, which is one of the important chemotherapy drugs used for treating of acute lymphocytic leukemia: kinetic ordinary differential equations and random Boolean…

Molecular Networks · Quantitative Biology 2016-11-02 Anastasia I. Lavrova , Eugene B. Postnikov , Andrey Yu. Zyubin , Svetlana V. Babak

Model predictive control (MPC) is an effective approach to control multivariable dynamic systems with constraints. Most real dynamic models are however affected by plant-model mismatch and process uncertainties, which can lead to…

Systems and Control · Electrical Eng. & Systems 2022-11-29 Zhengang Zhong , Ehecatl Antonio del Rio-Chanona , Panagiotis Petsagkourakis