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Retrosynthesis involves determining a sequence of reactions to synthesize complex molecules from simpler precursors. As this poses a challenge in organic chemistry, machine learning has offered solutions, particularly for predicting…

Machine Learning · Computer Science 2023-10-12 Mikołaj Sacha , Michał Sadowski , Piotr Kozakowski , Ruard van Workum , Stanisław Jastrzębski

Calculating hydrocarbon components solubility of natural gases is known as one of the important issues for operational works in petroleum and chemical engineering. In this work, a novel solubility estimation tool has been proposed for…

Machine Learning · Computer Science 2020-09-10 Narjes Nabipour , Amir Mosavi , Alireza Baghban , Shahaboddin Shamshirband , Imre Felde

Autonomous computations that rely on automated reaction network elucidation algorithms may pave the way to make computational catalysis on a par with experimental research in the field. Several advantages of this approach are key to…

Materials Science · Physics 2022-03-18 Miguel Steiner , Markus Reiher

Identifying minimum-energy paths (MEPs) is crucial for understanding chemical reaction mechanisms but remains computationally demanding. We introduce MEPIN, a scalable machine-learning method for efficiently predicting MEPs from reactant…

Chemical Physics · Physics 2026-02-18 Juno Nam , Miguel Steiner , Max Misterka , Soojung Yang , Avni Singhal , Rafael Gómez-Bombarelli

This paper presents a modeling study of the oxidation of cyclohexane from low to intermediate temperature (650-1050 K), including the negative temperature coefficient (NTC) zone. A detailed kinetic mechanism has been developed using…

Gaining insights into flame behaviour at small scales can lead to improvements in the efficiency of micro-reactors, compact power generation systems, fire safety technologies, and various other applications where combustion is confined to…

Fluid Dynamics · Physics 2026-02-24 M Ashwin Ganesh , Akhil Aravind , Balasundaram Mohan , Saptarshi Basu

An in-house large-eddy simulation (LES) code is applied to compute the chemically reacting flow in a turbine stage to analyze the influence of fuel injection and combustion on its aerodynamic and thermodynamic performance. Two reacting…

Fluid Dynamics · Physics 2026-04-01 Yalu Zhu , Feng Liu , William A. Sirignano

A method to calculate reactions in quantum mechanics is outlined. It is advantageous, in particular, in problems with many open channels of various nature i.e. when energy is not low. In the method there is no need to specify reaction…

Nuclear Theory · Physics 2017-01-06 V. D. Efros

Understanding and prediction of the chemical reactions are fundamental demanding in the study of many complex chemical systems. Reactive molecular dynamics (MD) simulation has been widely used for this purpose as it can offer atomic details…

Chemical Physics · Physics 2020-11-12 Jinzhe Zeng , Liqun Cao , Mingyuan Xu , Tong Zhu , John ZH Zhang

Mapping reaction pathways and transition states (TS) is fundamental to chemistry but computationally expensive at scale. The minimum energy pathway (MEP) dictates reaction rates and mechanisms, yet recovering it via electronic-structure…

Chemical Physics · Physics 2026-05-25 Rémi Schlama , Philippe Schwaller

The utilization of renewable energy technologies, particularly hydrogen, has seen a boom in interest and has spread throughout the world. Ethanol steam reformation is one of the primary methods capable of producing hydrogen efficiently and…

Analysis of PDEs · Mathematics 2023-04-27 Robert Joseph George , Xinwei Yu

The present work reports on the numerical investigation of NOx in three turbulent piloted diffusion flames of different levels of extinction. The study involves two-dimensional axisymmetric modeling of combustion in these flames with fairly…

Fluid Dynamics · Physics 2021-03-03 Rohit Saini , Swetha Prakash , Ashoke De , Rakesh Yadav

We developed an automated approach to construct the complex reaction network and explore the reaction mechanism for several reactant molecules. The nanoreactor type molecular dynamics was employed to generate possible chemical reactions, in…

Chemical Physics · Physics 2023-12-05 Yutai Zhang , Chao Xu , Zhenggang Lan

The mechanisms of direct detonation initiation (DDI) in methane/air mixtures containing coal particles are investigated through simulations conducted using the Eulerian-Lagrangian method in a two-dimensional configuration. Methane-air…

Chemical Physics · Physics 2025-03-05 Shengnan Li , Shangpeng Li , Shumeng Xie , Yong Xu , Ke Gao , Huangwei Zhang

This work surveys an r-adaptive moving mesh finite element method for the numerical solution of premixed laminar flame problems. Since the model of chemically reacting flow involves many different modes with diverse length scales, the…

Numerical Analysis · Mathematics 2020-08-26 Zhen Sun , Malte Braack , Jens Lang

Accurately modeling chemical reactions at the atomistic level requires high-level electronic structure theory due to the presence of unpaired electrons and the need to properly describe bond breaking and making energetics. Commonly used…

Retrosynthesis analysis is pivotal yet challenging in drug discovery and organic chemistry. Despite the proliferation of computational tools over the past decade, AI-based systems often fall short in generalizing across diverse reaction…

Machine Learning · Computer Science 2024-08-21 Yifei Yang , Runhan Shi , Zuchao Li , Shu Jiang , Bao-Liang Lu , Yang Yang , Hai Zhao

We train an equivariant machine learning model to predict energies and forces for a real-world study of hydrogen combustion under conditions of finite temperature and pressure. This challenging case for reactive chemistry illustrates that…

Chemical Physics · Physics 2023-06-16 Xingyi Guan , Joseph Heindel , Taehee Ko , Chao Yang , Teresa Head-Gordon

There has been great progress in developing methods for machine-learned potential energy surfaces. There have also been important assessments of these methods by comparing so-called learning curves on datasets of electronic energies and…

Chemical Physics · Physics 2022-06-28 Joel M. Bowman , Chen Qu Riccardo Conte , Apurba Nandi , Paul L. Houston , Qi Yu

Motivated by the work of Cooper & Showman, we revisit the chemical relaxation method, which seeks to enhance the computational efficiency of chemical-kinetics calculations by replacing the chemical network with a handful of independent…

Earth and Planetary Astrophysics · Physics 2018-08-01 Shang-Min Tsai , Daniel Kitzmann , James R. Lyons , João Mendonça , Simon L. Grimm , Kevin Heng
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