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A two-dimensional resonant inelastic x-ray scattering (2D-RIXS) microscopy system has been developed at the beamline BL02U of NanoTerasu. The instrument combines a Wolter type-I mirror for spatial imaging with a varied-line-spacing grating…

Materials Science · Physics 2026-05-07 Kohei Yamamoto , Hakuto Suzuki , Jun Miyawaki

We demonstrate a label-free, scan-free {\it intensity} diffraction tomography technique utilizing annular illumination (aIDT) to rapidly characterize large-volume 3D refractive index distributions in vitro. By optimally matching the…

Optics · Physics 2020-01-01 Jiaji Li , Alex Matlock , Yunzhe Li , Qian Chen , Chao Zuo , Lei Tian

High-resolution chemical imaging within deep tissues and intact spheroids remains a grand challenge. Here, we introduce mid-wave infrared photothermal (MWIP) microscopy operating in the underexplored 2000-2500 nm spectral window for…

Gastrointestinal (GI) tract cancers pose a global health challenge, demanding precise radiotherapy planning for optimal treatment outcomes. This paper introduces a cutting-edge approach to automate the segmentation of GI tract regions in…

Image and Video Processing · Electrical Eng. & Systems 2024-01-30 Ye Zhang , Yulu Gong , Dongji Cui , Xinrui Li , Xinyu Shen

There has been a longstanding expectation that the optical resolution embodiment of photoacoustic tomography could have a substantial impact on gastrointestinal endoscopy by enabling microscopic visualization of the vasculature based on the…

Gastrointestinal (GI) pathologies are periodically screened, biopsied, and resected using surgical tools. Usually the procedures and the treated or resected areas are not specifically tracked or analysed during or after colonoscopies.…

Deep-tissue chemical imaging plays a vital role in biological and medical applications. Here, we present a shortwave infrared photothermal (SWIP) microscope for millimeter-deep vibrational imaging with sub-micron lateral resolution and…

Long wavelength infrared (8-13 $\mu$m) spectroscopy is invaluable for detecting molecular features in the atmospheres of gas giant and terrestrial exoplanets. The nulling-optimized mid-infrared camera (NOMIC) on the Large Binocular…

Earth and Planetary Astrophysics · Physics 2024-07-08 Brittany E. Miles , Steve Ertel , Kevin Wagner , Daniel Apai

Recent work on mid-infrared (MIR) detection through the process of non-degenerate two-photon absorption (NTA) in semiconducting materials has shown that wide-field MIR imaging can be achieved with standard Si cameras. While this approach…

Three-dimensional molecular imaging of living cells is essential for unraveling cellular metabolism and response to therapies. However, existing volumetric methods, including fluorescence microscopy and quantitative phase imaging, either…

Label-free vibrational microscopy provides chemically specific access to cellular structure, yet quantitative volumetric chemical dynamics in living cells remain largely inaccessible, particularly on subsecond timescales relevant to…

Magnetic resonance (MR) images collected in 2D clinical protocols typically have large inter-slice spacing, resulting in high in-plane resolution and reduced through-plane resolution. Super-resolution technique can enhance the through-plane…

Image and Video Processing · Electrical Eng. & Systems 2023-03-21 Xin Wang , Sheng Wang , Honglin Xiong , Kai Xuan , Zixu Zhuang , Mengjun Liu , Zhenrong Shen , Xiangyu Zhao , Lichi Zhang , Qian Wang

Tissue oxygenation and perfusion can be an indicator for organ viability during minimally invasive surgery, for example allowing real-time assessment of tissue perfusion and oxygen saturation. Multispectral imaging is an optical modality…

Computer Vision and Pattern Recognition · Computer Science 2017-06-23 Geoffrey Jones , Neil T Clancy , Xiaofei Du , Maria Robu , Simon Arridge , Daniel S Elson , Danail Stoyanov

Circular aperture probes have been successfully used for high-resolution near-field microwave imaging. It has been established that circular aperture probes could conceivably provide higher image fidelity compared to rectangular aperture…

Systems and Control · Electrical Eng. & Systems 2022-12-13 Zubair Akhter , MS Rahman , M Aboukhousa

Fluorophores emitting in the NIR-IIb wavelength range (1.5 micron - 1.7 micron) show great potential for bioimaging due to their large tissue penetration. However, current fluorophores suffer from poor emission with quantum yields ~2% in…

Materials Science · Physics 2023-01-26 Ananth Kamath , Richard D. Schaller , Philippe Guyot-Sionnest

Thick tissue sections strongly scatter and absorb light, which limits transmission-based label-free examination via quantitative phase imaging (QPI) modalities. Here we introduce a simple, room-temperature optical clearing medium - glycerol…

Post-endoscopic gastrointestinal (GI) rebleeding frequently occurs within the first 72 hours after therapeutic hemostasis and remains a major cause of early morbidity and mortality. Existing non-invasive monitoring approaches primarily…

Image and Video Processing · Electrical Eng. & Systems 2026-01-27 Yunhao Bian , Dawei Wang , Mingyang Shen , Xinze Li , Jiayi Shi , Ziyao Zhou , Tiancheng Cao , Hen-Wei Huang

Temporal ghost imaging (TGI) enables ultrafast signal reconstruction beyond electronic bandwidth limits. Extending this concept to the mid-infrared (MIR) regime through nonlinear frequency conversion offers new opportunities for…

Optics · Physics 2026-05-22 Ziyu He , Kun Huang , Huijie Ma , Wen Zhang , Jianan Fang , Heping Zeng

Mid-infrared (mid-IR) spectroscopy is a crucial workhorse for a plethora of analytical applications and is suitable for diverse materials, including gases, polymers or biological tissue. However, this technologically significant wavelength…

Optics · Physics 2022-02-23 Paul Kaufmann , Helen M. Chrzanowski , Aron Vanselow , Sven Ramelow

Endoscopy provides a major contribution to the diagnosis of the Gastrointestinal Tract (GIT) diseases. With Colon Endoscopy having its certain limitations, Wireless Capsule Endoscopy is gradually taking over it in the terms of ease and…

Image and Video Processing · Electrical Eng. & Systems 2020-09-03 Vanshika Vats , Pooja Goel , Amodini Agarwal , Nidhi Goel