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Chirality is a feature of many biological systems and much research has been focused on understanding the origin and implications of this property. Famously, sugars and amino acids found in nature are homochiral, i.e., chiral symmetry is…

Cell Behavior · Quantitative Biology 2023-07-28 Ludwig A. Hoffmann , Luca Giomi

Chirality is a fundamental property of great importance in physics, chemistry, and biology, and has recently been found to generate unexpected spin polarization for electrons passing through organic molecules, known as chirality-induced…

Mesoscale and Nanoscale Physics · Physics 2024-01-25 Qun Yang , Yongkang Li , Claudia Felser , Binghai Yan

Many of the building blocks of life such as amino acids and nucleotides are chiral, i.e., different from their mirror image. Contemporary life selects and synthesizes only one of two possible handednesses. In an abiotic environment,…

Biomolecules · Quantitative Biology 2022-09-20 Axel Brandenburg

The chirality-induced spin selectivity (CISS) effect gives rise to strongly spin-dependent transport through many organic molecules and structures. Its discovery raises fascinating fundamental questions as well as the prospect of possible…

Mesoscale and Nanoscale Physics · Physics 2023-01-18 Dan Klein , Karen Michaeli

Life is homochiral and homochirality is a fundamental feature of living systems on Earth. While the exact mechanism that led to homochirality is still not fully understood, any realistic scenario on the origins of life needs to address the…

Chirality-induced spin selectivity (CISS) describes how chiral molecules and materials generate spin polarization even at thermal equilibrium. This observation has challenged established principles of microscopic reversibility and Onsager…

Strongly Correlated Electrons · Physics 2025-10-29 Pius M. Theiler , Matthew C. Beard

The observation of chiral-induced spin selectivity (CISS) in biological molecules still awaits a full theoretical explanation. In a recent Rapid Communication, Varela et al. [Phys. Rev. B 101, 241410(R) (2020)] presented a model for…

Mesoscale and Nanoscale Physics · Physics 2021-02-24 Ora Entin-Wohlman , Amnon Aharony , Yasuhiro Utsumi

Chirality is breaking of mirror symmetry in matter. In the fields of biology and chemistry, this is particularly important because some of the essential molecules in life such as amino acids and DNA have chirality. It is a long-standing…

Strongly Correlated Electrons · Physics 2019-07-04 N. Jiang , Y. Nii , H. Arisawa , E. Saitoh , Y. Onose

Most amino acids and sugars molecules occur in mirror, or chiral, images of each other, knowns as enantiomers. However, life on Earth is mostly homochiral: proteins contain almost exclusively L-amino acids, while only D-sugars appear in RNA…

Earth and Planetary Astrophysics · Physics 2022-12-29 Marcelo Gleiser

Chirality pervades multiple scientific domains-physics, chemistry, biology, and astronomy-and profoundly influences their foundational principles. Recently, the chirality-induced spin selectivity (CISS) phenomenon has captured significant…

Life demonstrates remarkable homochirality of its major building blocks: nucleic acids, amino acids, sugars, and phospholipids. We propose a mechanism that places the root of life homochirality in the formation of phospholipid bilayer…

Populations and Evolution · Quantitative Biology 2025-12-30 Vladimir Subbotin , Gennady Fiksel

The interplay between chirality and magnetism has been a source of fascination among scientists for over a century. In recent years, chirality-induced spin selectivity (CISS) has attracted renewed interest. It has been observed that…

Mesoscale and Nanoscale Physics · Physics 2024-08-07 Mohammad Reza Safari , Frank Matthes , Claus M. Schneider , Karl-Heinz Ernst , Daniel E. Bürgler

Chirality or the property that distinguishes lefthandedness from righthandedness is an important aspect of the universe, starting from neutrinos, which are lefthanded. Fifteen years ago the author had proposed that life on the earth was…

General Physics · Physics 2009-11-01 Burra G. Sidharth

Since the chiral-induced spin selectivity (CISS) was first observed experimentally, its microscopic mechanism has been continuously explored by the scientific community. Among these investigations, the non-equilibrium effects and the…

Mesoscale and Nanoscale Physics · Physics 2023-09-12 Song Chen , Hua-Hua Fu

In this paper, I tentatively put forward a new hypothesis that the emergence of a single chiral form of biomolecules in living organisms is specifically determined by the electron spin state during their enzyme-catalyzed synthesis…

Biological Physics · Physics 2016-07-06 Wei Wang

The chiral-induced spin selectivity (CISS) effect, a phenomenon where the chirality of molecules imparts significant spin selectivity to electron transfer processes, has garnered increasing interest among the chemistry, biology, and physics…

Chemical Physics · Physics 2025-09-05 Tian-Yi Zhang , Yue Mao , Ai-Min Guo , Qing-Feng Sun

Chirality induced spin selectivity, discovered about two decades ago in helical molecules, is a non-equilibrium effect that emerges from the interplay between geometrical helicity and spin-orbit interactions. Several model Hamiltonians…

Mesoscale and Nanoscale Physics · Physics 2019-11-13 J. Fransson

The origin and function of chirality in DNA, proteins, and other building blocks of life represent a central question in biology. Observations of spin polarization and magnetization associated with electron transport through chiral…

The chiral(ity)-induced spin selectivity (CISS) effect, where electrons passing through a chiral medium acquire significant spin-polarization at ambient temperatures, has been widely observed experimentally, yet its theoretical foundations…

Chemical Physics · Physics 2025-09-03 Yan Xi Foo , Aisha Kermiche , Farhan T. Chowdhury , Clarice D. Aiello , Luke D. Smith

The interaction between electron spin and molecular chirality plays a fundamental role in quantum phenomena, with significant implications for spintronics and quantum computing. The chirality-induced spin selectivity (CISS) effect, where…