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Life as we know it is homochiral, but the origins of biological homochirality on early Earth remain elusive. Shallow closed-basin lakes are a plausible prebiotic environment on early Earth, and most are expected to have significant…

Chemical Physics · Physics 2025-04-15 S. Furkan Ozturk , Dimitar D. Sasselov

The emergence of biomolecular homochirality is a critically important question about life phenomenon and the origins of life. In a previous paper (arXiv:1309.1229), I tentatively put forward a new hypothesis that the emergence of a single…

Biological Physics · Physics 2015-04-06 Wei Wang

The emergence of biomolecular homochirality is a critical open question in the field of origins of life. In order to seek out an answer to this unsettled issue, a number of mechanisms have been offered over time, but it still remains a…

Biological Physics · Physics 2020-01-13 Wei Wang

Biomolecules that constitute life on Earth are chiral, but the precise mechanism by which homochirality emerged remains a mystery. In this work it is demonstrated that reactions of radical pairs, where one of the radical electron spins is…

Chemical Physics · Physics 2025-08-08 Thomas P Fay

The search for life elsewhere in the universe is a pivotal question in modern science. However, to address whether life is common in the universe we must first understand the likelihood of abiogenesis by studying the origin of life on…

Astrophysics · Physics 2008-11-11 Marcelo Gleiser , Sara Imari Walker

A key open question in the study of life is the origin of biomolecular homochirality: almost every life-form on Earth has exclusively levorotary amino acids and dextrorotary sugars. Will the same handedness be preferred if life is found…

Biomolecules · Quantitative Biology 2015-06-04 Marcelo Gleiser , Sara Imari Walker

For over two decades, the role of structural chirality in spin polarization has been widely investigated, with implications for the origins of life, catalysis, and quantum phenomena. Yet, it remains unclear whether all chirality-induced…

Mesoscale and Nanoscale Physics · Physics 2025-05-12 Pius M. Theiler , Sander Driessen , Matthew C. Beard

While biologists have not yet reached a consensus on the definition of life, homochirality - the specific molecular handedness of biomolecules - is a phenomenon only produced by life. The unraveling of its origin requires interdisciplinary…

Biological Physics · Physics 2021-10-06 Noemie Globus , Roger D. Blandford , Anatoli Fedynitch

(abridged) We review recent studies of chirality using circularly polarized light, along with the birth and evolution of life and planetary systems. Terrestrial life consists almost exclusively of one enantiomer, left-handed amino acids.…

Astrophysics of Galaxies · Physics 2011-12-08 Tsubasa Fukue

Living organisms exhibit consistent homochirality. It is argued that the specific, binary choice made is not an accident but is a consequence of parity violation in the weak interaction expressed by cosmic irradiation. The secondary muons…

Biological Physics · Physics 2019-11-07 Noemie Globus , Roger D. Blandford

Homochirality is a signature of life on Earth yet its origins remain an unsolved puzzle. Achieving homochirality is essential for a high-yielding prebiotic network capable of producing functional polymers like ribonucleic acid (RNA) and…

Biological Physics · Physics 2025-04-15 S. Furkan Ozturk , Ziwei Liu , John D. Sutherland , Dimitar D. Sasselov

The phenomenon of life is discussed within a framework of its origin as defined by four hypotheses. The 1. hypothesis says: Life, as we know, is (H-C-N-O) based and relies on the number of bulk (Na-Mg-P-S-Cl-K-Ca) and trace elements…

Astrophysics of Galaxies · Physics 2020-11-25 Vlado Valkovic , Jasmina Obhodas

Most biomolecules occur in mirror, or chiral, images of each other. However, life is homochiral: proteins contain almost exclusively levorotatory (L) amino acids, while only dextrorotatory (R) sugars appear in RNA and DNA. The mechanism…

Astrophysics · Physics 2009-06-23 Marcelo Gleiser , Joel Thorarinson , Sara Imari Walker

Spin-orbit coupling gives rise to a range of spin-charge interconversion phenomena in non-magnetic systems where certain spatial symmetries are reduced or absent. Chirality-induced spin selectivity (CISS), a term that generically refers to…

Mesoscale and Nanoscale Physics · Physics 2023-04-25 W. Dednam , M. A. García-Blázquez , Linda A. Zotti , E. B. Lombardi , C. Sabater , S. Pakdel , J. J. Palacios

Chiral-Induced Spin Selectivity (CISS) describes the emergence of spin-polarized electron transport in chiral systems without magnetic fields, a remarkable effect in light-element materials with weak intrinsic spin-orbit coupling (SOC).…

Molecular chirality is inherent to biology and cellular chemistry. In this report, the origin of enantiomeric selectivity is analyzed from the viewpoint of the "RNA World" model, based on the autocatalytic self-replication of glyceraldehyde…

Chemical Physics · Physics 2021-10-26 J. A. Cowan , R. J. Furnstahl

We provide a critical overview of the theory of the chirality-induced spin selectivity (CISS) effect, i.e., phenomena in which the chirality of molecular species imparts significant spin selectivity to various electron processes. Based on…

Chirality-induced spin selectivity (CISS) refers to the fact that electrons get spin polarized after passing through organic chiral molecules in a nanoscale device. In CISS, chiral molecules are commonly believed to be a spin filter through…

Mesoscale and Nanoscale Physics · Physics 2022-12-06 Yotam Wolf , Yizhou Liu , Jiewen Xiao , Noejung Park , Binghai Yan

Chirality has been a property of central importance in chemistry and biology for more than a century, and is now taking on increasing relevance in condensed matter physics. Recently, electrons were found to become spin polarized after…

Chirality-induced spin selectivity (CISS) generates spin-polarized currents in nonmagnetic materials from structural chirality alone, yet its microscopic origin remains debated. Using a first-principles spatiotemporal density-matrix…

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