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We use numerical simulations to demonstrate third-harmonic generation with near-unity nonlinear circular dichroism (CD) and high conversion efficiency ($ 10^{-2}\ \text{W}^{-2}$) in asymmetric Si-on-SiO$_2$ metasurfaces. The working…

Circular dichroism, arising from interactions with light fields of opposite spin angular momentum, has become a fundamental tool for molecular characterization. Meanwhile, helical dichroism (HD) - the dichroic response to vortex beams…

We propose a Babinet-invertible chiral metasurface for achieving dynamically reversible and strong circular dichroism (CD). The proposed metasurface is composed of VO$_2$-metal hybrid structure, and when VO$_2$ transits between the…

Optics · Physics 2021-04-07 Xiaoqing Luo , Fangrong Hu , Guangyuan Li

Recent advancements in X-ray light sources at synchrotrons and X-ray free-electron lasers (XFELs) present exciting opportunities to probe molecular chirality using novel nonlinear spectroscopies with element-sensitivity. Circular dichroism…

Chemical Physics · Physics 2025-01-27 Yeonsig Nam , Majed Chergui , Linda Young , Jérémy R. Rouxel

Chiral molecule sensing is currently performed using chromatography, electrophoresis, enzymatic-assays, mass spectrometry, and chiroptical sensing techniques. Currently polarimetry is the only method having in-vivo sensing capabilities,…

Medical Physics · Physics 2024-01-22 Swathi Padmanabhan , Jaya Prakash

Circulating tumor cells (CTCs) are cancer cells found in the bloodstream that serve as biomarkers for early cancer detection, prognostication, and disease monitoring. However, CTC detection remains challenging due to low cell abundance and…

Chiral response is of tremendous importance to many fields, such as analytical chemistry, polarization manipulation and biological sensing. Here, a chiral metasurface based on rectangular holes is systematically investigated. The results…

Optics · Physics 2021-12-07 Biyuan Wu , Mingjun Wang , Yasong Sun , Feng Wu , Zhangxing Shi , Xiaohu Wu

Amino acids and other small chiral molecules play key roles in biochemistry. However, in order to understand how these molecules behave in vivo, it is necessary to study them under aqueous-phase conditions. Photoelectron circular dichroism…

We propose an enantio-detection method of chiral molecules in a cavity with external drive. The chiral molecules are coupled with a quantized cavity field and two classical light fields to form the cyclic three-level systems. The…

Quantum Physics · Physics 2022-02-15 Yu-Yuan Chen , Jian-Jian Cheng , Chong Ye , Yong Li

Chiral molecules with broken parity symmetries can be modeled as quantum systems with cyclic-transition structures. By using these novel properties, we design two-step laser pulses to distinguish left- and right-handed molecules from the…

Quantum Physics · Physics 2015-05-19 W. Z. Jia , L. F. Wei

Chiral optical terahertz (THz) devices have significant technological implications for telecommunications, spectroscopy, and sensing. Engineering tunable, broadband, and cost-effective THz chiral materials has long been recognized as a…

Chiral molecules exhibit enantiosensitive light-matter interactions, with photoelectron circular dichroism (PECD) serving as a sensitive probe of molecular chirality through the asymmetry in the photoelectron wavepacket amplitude. Here, we…

Atomic Physics · Physics 2025-05-07 Zheming Zhou , Yang Li , Xu Zhang , Yueming Zhou , Peixiang Lu

Circular dichroism (CD) sensing plays a pivotal role in probing molecular chirality in biomedical sciences. However, engineering superchiral electromagnetic fields that can reliably amplify the faint signatures of chiral analytes remains…

We demonstrate coherent control over the photoelectron circular dichroism in randomly oriented chiral molecules, based on quantum interference between multiple photoionization pathways. To significantly enhance the chiral signature, we use…

Quantum Physics · Physics 2019-01-16 R. Esteban Goetz , Christiane P. Koch , Loren Greenman

Automatic detection of dicentric chromosomes is an essential step to estimate radiation exposure and development of end to end emergency bio dosimetry systems. During accidents, a large amount of data is required to be processed for…

Computer Vision and Pattern Recognition · Computer Science 2022-04-19 Angad Singh Wadhwa , Nikhil Tyagi , Pinaki Roy Chowdhury

Separation of the two mirror images of a chiral molecule, the enantiomers, is a historically complicated problem of major relevance for biological systems. Since chiral molecules are optically active, it has been speculated that strong…

Chemical Physics · Physics 2024-10-23 Rosario R. Riso , Matteo Castagnola , Enrico Ronca , Henrik Koch

We develop photoelectron interferometry based on laser-assisted extreme ultraviolet ionization for flexible and robust control of photoelectron circular dichroism in randomly oriented chiral molecules. A comb of XUV photons ionizes a sample…

Metasurfaces, the two-dimensional analogues of metamaterials, are ideal platforms for sensing molecular chirality at the nanoscale, e.g. of inclusions of natural optically active molecules, as they offer large accessible areas (they are…

Applied Physics · Physics 2020-08-19 Sotiris Droulias

Detection of chiral molecules requires amplification of chirality to measurable levels. Typically, amplification mechanisms are considered at the microscopic scales of individual molecules and their aggregates. Here we demonstrate chirality…

Soft Condensed Matter · Physics 2015-07-28 Chenhui Peng , Oleg D. Lavrentovich

We show that the intensity of pumped states near Weyl point is different when pumped with left- and right-handed circular polarized light, which leads to a special circular dichroism (CD) in time-dependent angle resolved photoemission…

Materials Science · Physics 2016-05-25 Rui Yu , Hongming Weng , Zhong Fang , Hong Ding , Xi Dai