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Differential privacy is a rigorous privacy condition achieved by randomizing query answers. This paper develops efficient algorithms for answering multiple queries under differential privacy with low error. We pursue this goal by advancing…

Databases · Computer Science 2011-03-08 Chao Li , Gerome Miklau

Perfect data privacy seems to be in fundamental opposition to the economical and scientific opportunities associated with extensive data exchange. Defying this intuition, this paper develops a framework that allows the disclosure of…

Information Theory · Computer Science 2019-04-04 Borzoo Rassouli , Fernando E. Rosas , Deniz Gunduz

We show new lower bounds on the sample complexity of $(\varepsilon, \delta)$-differentially private algorithms that accurately answer large sets of counting queries. A counting query on a database $D \in (\{0,1\}^d)^n$ has the form "What…

Cryptography and Security · Computer Science 2018-10-25 Mark Bun , Jonathan Ullman , Salil Vadhan

We live in a period where bio-informatics is rapidly expanding, a significant quantity of genomic data has been produced as a result of the advancement of high-throughput genome sequencing technology, raising concerns about the costs…

Quantitative Methods · Quantitative Biology 2023-03-10 Mehedi Hasan Sarkar , Adnan Ferdous Ashrafi

In some socio-economic surveys, data are collected on sensitive or stigmatizing issues such as tax evasion, criminal conviction, drug use, etc. In such surveys, direct questioning of respondents is not of much use and the randomized…

Statistics Theory · Mathematics 2013-03-22 Mausumi Bose

The projected increase of genotyping in the clinic and the rise of large genomic databases has led to the possibility of using patient medical data to perform genomewide association studies (GWAS) on a larger scale and at a lower cost than…

Quantitative Methods · Quantitative Biology 2016-04-18 Sean Simmons , Cenk Sahinalp , Bonnie Berger

Sparse histogram methods can be useful for returning differentially private counts of items in large or infinite histograms, large group-by queries, and more generally, releasing a set of statistics with sufficient item counts. We consider…

Cryptography and Security · Computer Science 2022-02-03 Brian Karrer , Daniel Kifer , Arjun Wilkins , Danfeng Zhang

Access to genomic data is highly regulated due to its sensitive nature. While safeguards are essential, cumbersome data access processes pose a significant barrier to the development of AI methods for genomics. Synthetic data generation can…

Cryptography and Security · Computer Science 2026-05-01 Daniil Filienko , Martine De Cock , Sikha Pentyala

Statistical model checking is a class of sequential algorithms that can verify specifications of interest on an ensemble of cyber-physical systems (e.g., whether 99% of cars from a batch meet a requirement on their energy efficiency). These…

Machine Learning · Computer Science 2022-06-29 Yu Wang , Hussein Sibai , Mark Yen , Sayan Mitra , Geir E. Dullerud

We study the problem of performing counting queries at different levels in hierarchical structures while preserving individuals' privacy. Motivated by applications, we propose a new error measure for this problem by considering a…

Data Structures and Algorithms · Computer Science 2023-04-28 Badih Ghazi , Pritish Kamath , Ravi Kumar , Pasin Manurangsi , Kewen Wu

In this paper, we study methods for improving the efficiency and privacy of compressed DNA sequence comparison computations, under various querying scenarios. For instance, one scenario involves a querier, Bob, who wants to test if his DNA…

Cryptography and Security · Computer Science 2011-07-20 David Eppstein , Michael T. Goodrich , Pierre Baldi

A cache-aided compression problem with perfect privacy is studied, where a server has access to a database of $N$ files, $(Y_1,...,Y_N)$, each of size $F$ bits. The server is connected to $K$ users through a shared link, where each user has…

Information Theory · Computer Science 2025-06-17 Amirreza Zamani , Mikael Skoglund

Genome-wide association studies (GWAS) are an essential tool in biomedical research for identifying genetic factors linked to health and disease. However, publicly releasing GWAS summary statistics poses well-recognized privacy risks,…

Quantitative Methods · Quantitative Biology 2025-12-05 Anupama Nandi , Seth Neel , Hyunghoon Cho

Suppose there is a group of N people some of whom possess a specific property. For example, their wealth is above or below a threshold, they voted for a particular candidate, they have a certain disease, etc. The group wants to find out how…

Cryptography and Security · Computer Science 2007-05-23 Oleg Kiselyov

The problem we address is the following: how can a user employ a predictive model that is held by a third party, without compromising private information. For example, a hospital may wish to use a cloud service to predict the readmission…

Machine Learning · Computer Science 2014-12-25 Pengtao Xie , Misha Bilenko , Tom Finley , Ran Gilad-Bachrach , Kristin Lauter , Michael Naehrig

In this work we analyze the problem of, given the probability distribution of a population, questioning an unknown individual that is representative of the distribution so that our uncertainty about certain characteristics is significantly…

Computational Complexity · Computer Science 2026-01-22 David Pantoja , Ismael Rodriguez , Fernando Rubio , Clara Segura

Differential privacy is a leading protection setting, focused by design on individual privacy. Many applications, in medical / pharmaceutical domains or social networks, rather posit privacy at a group level, a setting we call integral…

Machine Learning · Statistics 2019-07-04 Hisham Husain , Zac Cranko , Richard Nock

The Gaussian mechanism is one differential privacy mechanism commonly used to protect numerical data. However, it may be ill-suited to some applications because it has unbounded support and thus can produce invalid numerical answers to…

Cryptography and Security · Computer Science 2022-12-01 Bo Chen , Matthew Hale

Deep generative models are often trained on sensitive data, such as genetic sequences, health data, or more broadly, any copyrighted, licensed or protected content. This raises critical concerns around privacy-preserving synthetic data, and…

We give a new proof of the "transfer theorem" underlying adaptive data analysis: that any mechanism for answering adaptively chosen statistical queries that is differentially private and sample-accurate is also accurate out-of-sample. Our…

Machine Learning · Computer Science 2024-06-05 Christopher Jung , Katrina Ligett , Seth Neel , Aaron Roth , Saeed Sharifi-Malvajerdi , Moshe Shenfeld