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This paper proposes a multi-shell sampling scheme and corresponding transforms for the accurate reconstruction of the diffusion signal in diffusion MRI by expansion in the spherical polar Fourier (SPF) basis. The sampling scheme uses an…

Computer Vision and Pattern Recognition · Computer Science 2017-05-15 Alice P. Bates , Zubair Khalid , Jason D. McEwen , Rodney A. Kennedy

A three-dimensional cell culture called a spheroid serves as a foundational entity in a wide variety of modern tissue engineering applications, including 3D-bioprinting and preclinical drug testing. Lack of oxygen within tissue spheroids…

Computational Physics · Physics 2025-02-05 Katherine Vilinski-Mazur , Bogdan Kirillov , Oleg Rogozin , Dmitry Kolomenskiy

We present a new method for modeling tissue perfusion on the capillary scale. The microvasculature is represented by a network of one-dimensional vessel segments embedded in the extra-vascular space. Vascular and extra-vascular space…

Computational Physics · Physics 2020-03-23 Timo Koch , Martin Schneider , Rainer Helmig , Patrick Jenny

The measurement of cellular traction forces on soft elastic substrates has become a standard tool for many labs working on mechanobiology. Here we review the basic principles and different variants of this approach. In general, the…

Quantitative Methods · Quantitative Biology 2015-06-09 Ulrich S. Schwarz , Jerome R. D. Soine

Muscle contraction is often detected via EMG in prosthetics. However, signal disturbances due to electrode motions can lead to misinterpretations. Therefore, alternative measurement approaches are desired to increase the reliability of the…

Medical Physics · Physics 2020-09-17 Roman Kusche , Martin Ryschka

Functional Spectral Imaging (FSI) models image formation as the recovery of tissue surrogates such as density and stiffness from spectral perturbations of a self-adjoint elliptic operator. Rather than relying on reflectivity or relaxation…

Medical Physics · Physics 2025-10-21 Cesar Mello Fernando Medina da Cunha

The discrete fracture model (DFM) has been widely used in the simulation of fluid flow in fractured porous media. Traditional DFM uses the so-called hybrid-dimensional approach to treat fractures explicitly as low-dimensional entries (e.g.…

Numerical Analysis · Mathematics 2021-02-01 Ziyao Xu , Yang Yang

Soft biological tissues demonstrate strong time-dependent and strain-rate mechanical behavior, arising from their intrinsic visco-elasticity and fluid-solid interactions (especially at sufficiently large time scales). The time-dependent…

Tissues and Organs · Quantitative Biology 2023-06-09 Thomas Lavigne , Stéphane Urcun , Pierre-Yves Rohan , Giuseppe Sciumè , Davide Baroli , Stéphane P. A. Bordas

Multiplex Imaging (MI) enables the simultaneous visualization of multiple biological markers in separate imaging channels at subcellular resolution, providing valuable insights into cell-type heterogeneity and spatial organization. However,…

Image and Video Processing · Electrical Eng. & Systems 2024-11-07 Simon Gutwein , Daria Lazic , Thomas Walter , Sabine Taschner-Mandl , Roxane Licandro

We introduce a full field fluorescence imaging technique with axial confinement of about 100 nm at the sample/substrate interface. Contrary to standard surface imaging techniques, this confinement is obtained through emission filtering.…

Neurosurgery interventions involve complex tracking systems because a tissue deformation takesplace. The neuronavigation system relies only on preoperative images. In order to overcome the soft tissue deformations and guarantee the accuracy…

Medical Physics · Physics 2007-10-03 Claudio Lobos , Marek Bucki , Yohan Payan , Nancy Hitschfeld

Diffusion pore imaging is an extension of diffusion-weighted nuclear magnetic resonance imaging enabling the direct measurement of the shape of arbitrarily formed, closed pores by probing diffusion restrictions using the motion of…

Cross-term spatiotemporal encoding (xSPEN) is a recently introduced imaging approach delivering single-scan 2D NMR images with unprecedented resilience to field inhomogeneities. The method relies on performing a pre-acquisition encoding and…

Medical Physics · Physics 2017-08-25 Eddy Solomon , Gilad Liberman , Zhiyong Zhang , Lucio Frydman

The flexoelectric (FE) effect provides a linear coupling between electric polarization and orientational deformation in liquid crystals. It influences many electrooptical phenomena and it is used in some bistable nematic devices. A…

Soft Condensed Matter · Physics 2023-07-19 A. Kapanowski

In vivo, eukaryotic cells are embedded in a matrix environment, where they grow and develop. Generally, this extracellular matrix (ECM) is an anisotropic fibrous structure, through which macromolecules and biochemical signaling molecules at…

Biological Physics · Physics 2020-01-06 David Gomez , Sari Natan , Yair Shokef , Ayelet Lesman

We use a numerical electromagnetic simulation software to investigate a filtering device consisting of a small dimensional microstrips embedded with a thin layer of ferromagnetic material and we compare our results to experimental results.…

Materials Science · Physics 2008-02-20 Jonah N. Gollub , Bijoy Kuanr , Zibigniew Celinski , Robert Camley , David R. Smith

Accurate modeling of moving boundaries and interfaces is a difficulty present in many situations of computational mechanics. We use the eXtreme Mesh deformation approach (X-Mesh) to simulate the interaction between two immiscible flows…

Computational Engineering, Finance, and Science · Computer Science 2024-02-02 Antoine Quiriny , Jonathan Lambrechts , Nicolas Moës , Jean-François Remacle

While high-resolution microscopic techniques are crucial for studying cellular structures in cell biology, obtaining such images from thick 3D engineered tissues remains challenging. In this review, we explore advancements in fluorescence…

Tissues and Organs · Quantitative Biology 2025-02-07 Yasaman Kargar Gaz Kooh , Nathaniel Huebsch

Liquid-liquid phase separation has emerged as a fundamental mechanism underlying intracellular organization, with evidence for it being reported in numerous different systems. However, there is a growing concern regarding the lack of…

Soft Condensed Matter · Physics 2022-12-09 Mrityunjay Kothari , Tal Cohen

Computed Tomography (CT) imaging, while essential for diagnostics, exposes patients to ionizing radiation. To accurately quantify radiation dosage, this study introduces MIDSX, a specialized open-source Monte Carlo (MC) photon transport…

Medical Physics · Physics 2023-11-29 John Meneghini