Related papers: A Model-Based Architecture for Automatic Anesthesi…
This paper proposes an adaptive neuro-fuzzy framework to improve drug infusion rate in closed-loop control of anesthesia. The proposed controller provides a sub-optimal propofol administration rate as input to reach the desired bispectral…
In this paper, a multi-model predictive control approach is used to automate the co-administration of propofol and remifentanil from bispectral index measurement during general anesthesia. To handle the parameter uncertainties in the…
Significant effort toward the automation of general anesthesia has been made in the past decade. One open challenge is in the development of control-ready patient models for closed-loop anesthesia delivery. Standard depth-of-anesthesia…
This paper proposes a constrained control scheme for the control of the depth of hypnosis during induction phase in clinical anesthesia. In contrast with existing control schemes for propofol delivery, the proposed scheme guarantees…
Accurately predicting anesthetic effects is essential for target-controlled infusion systems. The traditional (PK-PD) models for Bispectral index (BIS) prediction require manual selection of model parameters, which can be challenging in…
We obtain an analytical solution for the time-optimal control problem in the induction phase of anesthesia. Our solution is shown to align numerically with the results obtained from the conventional shooting method. The induction phase of…
Medical drug infusion problems pose a combination of challenges such as nonlinearities from physiological models, model uncertainty due to inter- and intra-patient variability, as well as strict safety specifications. With these challenges…
This work provides a formalized model-invariant safety system for closed-loop anesthesia that uses feedback from measured data for model falsification to reduce conservatism. The safety system maintains predicted propofol plasma…
We present a non-linear dynamical system for modelling the effect of drug infusions on the vital signs of patients admitted in Intensive Care Units (ICUs). More specifically we are interested in modelling the effect of a widely used…
In this paper, an efficient control strategy for physiological interaction based anaesthetic drug infusion model is explored using the fractional order (FO) proportional integral derivative (PID) controllers. The dynamic model is composed…
In this paper, an MPC for tracking formulation is proposed for the control of anesthesia dynamics. It seamlessly enables the optimization of the steady-states pair that is not unique due to the MISO nature of the model. Anesthesia dynamics…
The development of a fully autonomous artificial pancreas system (APS) to independently regulate the glucose levels of a patient with Type 1 diabetes has been a long-standing goal of diabetes research. A significant barrier to progress is…
Estimating intervention effects in dynamical systems is crucial for outcome optimization. In medicine, such interventions arise in physiological regulation (e.g., cardiovascular system under fluid administration) and pharmacokinetics, among…
This paper proposes a mathematical approach for robust control of a nanoscale drug delivery system in treatment of atherosclerosis. First, a new nonlinear lumped model is introduced for mass transport in the arterial wall, and its accuracy…
Closed loop anesthesia delivery (CLAD) systems can help anesthesiologists efficiently achieve and maintain desired anesthetic depth over an extended period of time. A typical CLAD system would use an anesthetic marker, calculated from…
The cerebral autoregulation system (CAS), is a mechanism which aims to regulate pressure variations occurring in the cerebral circulatory system. At present, there only exist invasive methods and, in turn, they are not used to prevent…
The management of type 1 diabetes has been revolutionized by the artificial pancreas system (APS), which automates insulin delivery based on continuous glucose monitor (CGM). While conventional closed-loop systems rely on CGM data, which…
This study investigates the paradigm of intraoperative analgesic dosage using a data-driven approach based on retrospective clinical data. Remifentanil, an analgesic widely used during anesthesia, presents a dosing challenge due to the…
This paper addresses the challenge of amplitude-unbounded false data injection (FDI) attacks targeting the sensor-to-controller (S-C) channel in cyber-physical systems (CPSs). We introduce a resilient tube-based model predictive control…
This study presents a noise-robust closed-loop control strategy for wake flows employing model predictive control. The proposed control framework involves the autonomous offline selection of hyperparameters, eliminating the need for user…