In this paper, a multi-model predictive control approach is used to automate the co-administration of propofol and remifentanil from bispectral index measurement during general anesthesia. To handle the parameter uncertainties in the non-linear output function, multiple Extended Kalman Filters are used to estimate the state of the system in parallel. The best model is chosen using a model-matching criterion and used in a non-linear MPC to compute the next drug rates. The method is compared with a conventional non-linear MPC approach and a PID from the literature. The robustness of the controller is evaluated using Monte-Carlo simulations on a wide population introducing uncertainties in the models. Both simulation setup and controller codes are accessible in open source for further use. Our preliminary results show the potential interest in using a multi-model method to handle parameter uncertainties.
@article{arxiv.2309.08229,
title = {Automated Multi-Drugs Administration During Total Intravenous Anesthesia Using Multi-Model Predictive Control},
author = {Bob Aubouin-Pairault and Mirko Fiacchini and Thao Dang},
journal= {arXiv preprint arXiv:2309.08229},
year = {2023}
}