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Isolated sarcoplasmic reticulum vesicles in the presence of Mg(2+) and absence of Ca(2+) retain significant ATP hydrolytic activity that can be attributed to the Ca(2+)-ATPase protein. At neutral pH and the presence of 5 mM Mg(2+), the…

Molecular Networks · Quantitative Biology 2024-02-01 A Lax , F Soler , F Fernandez Belda

In the framework of irreversible thermodynamics, we study autonomous systems of reaction-diffusion equations to show how the entropy and free energy of an open and irreversible reactor depend on concentrations. To do this, we find a…

Statistical Mechanics · Physics 2022-07-13 Aldo Ledesma-Durán , Iván Santamaría-Holek

ATP synthases utilize a proton motive force to synthesize ATP. In reverse, these membrane-embedded enzymes can also hydrolyze ATP to pump protons over the membrane. To prevent wasteful ATP hydrolysis, distinct control mechanisms exist for…

Biomolecules · Quantitative Biology 2018-01-16 Hendrik Sielaff , Dhirendra Singh , Gerhard Grueber , Michael Börsch

In models with flavour symmetries added to the gauge group of the Standard Model the CP-violating asymmetry necessary for leptogenesis may be related with low-energy parameters. A particular case of interest is when the flavour symmetry…

High Energy Physics - Phenomenology · Physics 2011-04-22 Ivo de Medeiros Varzielas

F$_{1}$-ATPase is a rotary molecular motor that \emph{in vivo} is subject to strong nonequilibrium driving forces. There is great interest in understanding the operational principles governing its high efficiency of free-energy…

Statistical Mechanics · Physics 2022-12-29 Deepak Gupta , Steven J. Large , Shoichi Toyabe , David A. Sivak

Taking advantage from a recent analog realization of certain automata via spectral encodings as permutation machines, we reach at an improved version of the previously introduced remotely acting Maxwellian demon in arXiv:1408.3797. A number…

General Physics · Physics 2017-08-25 Theophanes E. Raptis

The asymptotic convergence of probability density function (pdf) and convergence of differential entropy are examined for the non-stationary processes that follow the maximum entropy principle (MaxEnt) and maximum entropy production…

Information Theory · Computer Science 2014-01-14 Alexander L. Fradkov , Dmitry S. Shalymov

Thermogenesis is a physiological activity of releasing heat that originates from intracellular biochemical reactions. Recent experimental studies discovered that externally applied heat changes intracellular signaling locally, resulting in…

Biological Physics · Physics 2023-02-28 Ikuo Kurisaki , Madoka Suzuki

We revisit here the mathematical model for ATP production in mitochondria introduced recently by Bertram, Pedersen, Luciani, and Sherman (BPLS) as a simplification of the more complete but intricate Magnus and Keizer's model. We identify…

Biological Physics · Physics 2014-04-22 Alberto Saa , Kellen M. Siqueira

Maxwell's demon explores the role of information in physical processes. Employing information about microscopic degrees of freedom, this "intelligent observer" is capable of compensating entropy production (or extracting work), apparently…

To synthesize proteins in a cell, an mRNA has to work with a finite pool of ribosomes. When this constraint is included in the modeling by a totally asymmetric simple exclusion process (TASEP), non-trivial consequences emerge. Here, we…

Statistical Mechanics · Physics 2010-09-01 L. Jonathan Cook , R. K. P. Zia

Identifying dissipation is essential for understanding the physical mechanisms underlying nonequilibrium processes. {In living systems, for example, the dissipation is directly related to the hydrolysis of fuel molecules such as adenosine…

Statistical Mechanics · Physics 2019-09-02 Ignacio A. Martínez , Gili Bisker , Jordan M. Horowitz , Juan M. R. Parrondo

F$_1$-ATPase (F$_1$) is central to cellular energy transduction. Forcibly rotated by another motor F$_\mathrm{o}$, F$_1$ catalyzes ATP synthesis by converting mechanical work into chemical free energy stored in the molecule ATP. The details…

Maxwell's demon (MD) has proven an instructive vehicle by which to explore the relationship between information theory and thermodynamics, fueling the possibility of information driven machines. A long standing debate has been the concern…

A discrete-state model of the F1-ATPase molecular motor is developed which describes not only the dependences of the rotation and ATP consumption rates on the chemical concentrations of ATP, ADP, and inorganic phosphate, but also on…

Subcellular Processes · Quantitative Biology 2009-04-28 E. Gerritsma , P. Gaspard

In mathematical physical analyses of Szilard's engine and Maxwell's demon, a general assumption (explicit or implicit) is that one can neglect the energy needed for relocating the piston in Szilard's engine and for driving the trap door in…

General Physics · Physics 2012-06-26 Laszlo B. Kish , Claes G. Granqvist

We experimentally showed that biological molecular motor F$_1$-ATPase (F$_1$) implements an optimal rectification mechanism. F$_1$ hardly suppresses adenosine triphosphate (ATP) synthesis, which is the F$_1$'s physiological role while…

Biological Physics · Physics 2021-05-24 Yohei Nakayama , Shoichi Toyabe

The diffusion of a molecular motor in the presence of a constant external force is considered on the basis of a simple theoretical model. The motor is represented by a Brownian particle moving in a series of parabolic potentials placed…

Statistical Mechanics · Physics 2016-06-01 Ryota Shinagawa , Kazuo Sasaki

The construction of the potential energy surface (PES) of even a medium-sized molecule employing correlated theory, such as CCSD(T), is an arduous task due to the high computational cost. In this Letter, we report the possibility of…

Chemical Physics · Physics 2022-05-04 Subodh S. Khire , Nalini D. Gurav , Apurba Nandi , Shridhar R. Gadre

Multiscale thermodynamics is a theory of relations among levels of description. Energy and entropy are its two main ingredients. Their roles in the time evolution describing approach of a level (starting level) to another level involving…

Statistical Mechanics · Physics 2024-02-26 Miroslav Grmela
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