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In digital pathology, different staining procedures and scanners cause substantial color variations in whole-slide images (WSIs), especially across different laboratories. These color shifts result in a poor generalization of deep…

Image and Video Processing · Electrical Eng. & Systems 2021-07-27 Sophia J. Wagner , Nadieh Khalili , Raghav Sharma , Melanie Boxberg , Carsten Marr , Walter de Back , Tingying Peng

Pathology is practiced by visual inspection of histochemically stained slides. Most commonly, the hematoxylin and eosin (H&E) stain is used in the diagnostic workflow and it is the gold standard for cancer diagnosis. However, in many cases,…

The recent direction of unpaired image-to-image translation is on one hand very exciting as it alleviates the big burden in obtaining label-intensive pixel-to-pixel supervision, but it is on the other hand not fully satisfactory due to the…

Computer Vision and Pattern Recognition · Computer Science 2019-02-27 Rui Zhang , Tomas Pfister , Jia Li

Three-dimensional X-ray histology techniques offer a non-invasive alternative to conventional 2D histology, enabling volumetric imaging of biological tissues without the need for physical sectioning or chemical staining. However, the…

Image and Video Processing · Electrical Eng. & Systems 2025-09-12 Sarah C. Irvine , Christian Lucas , Diana Krüger , Bianca Guedert , Julian Moosmann , Berit Zeller-Plumhoff

Variability in staining protocols, such as different slide preparation techniques, chemicals, and scanner configurations, can result in a diverse set of whole slide images (WSIs). This distribution shift can negatively impact the…

Image and Video Processing · Electrical Eng. & Systems 2023-04-25 Kudaibergen Abutalip , Numan Saeed , Mustaqeem Khan , Abdulmotaleb El Saddik

Different types of staining highlight different structures in organs, thereby assisting in diagnosis. However, due to the impossibility of repeated staining, we cannot obtain different types of stained slides of the same tissue area.…

Image and Video Processing · Electrical Eng. & Systems 2024-04-17 Zexin Li , Yiyang Lin , Zijie Fang , Shuyan Li , Xiu Li

Renal pathology, as the gold standard of kidney disease diagnosis, requires doctors to analyze a series of tissue slices stained by H&E staining and special staining like Masson, PASM, and PAS, respectively. These special staining methods…

Image and Video Processing · Electrical Eng. & Systems 2023-09-19 Tao Ma , Chao Zhang , Min Lu , Lin Luo

Accurate and fast histological staining is crucial in histopathology, impacting diagnostic precision and reliability. Traditional staining methods are time-consuming and subjective, causing delays in diagnosis. Digital pathology plays a…

Image and Video Processing · Electrical Eng. & Systems 2023-07-06 Marian Boktor , James E. D. Tweel , Benjamin R. Ecclestone , Jennifer Ai Ye , Paul Fieguth , Parsin Haji Reza

Recently image-to-image translation has attracted significant interests in the literature, starting from the successful use of the generative adversarial network (GAN), to the introduction of cyclic constraint, to extensions to multiple…

Computer Vision and Pattern Recognition · Computer Science 2020-01-16 Zengming Shen , S. Kevin Zhou , Yifan Chen , Bogdan Georgescu , Xuqi Liu , Thomas S. Huang

Staining is essential in cell imaging and medical diagnostics but poses significant challenges, including high cost, time consumption, labor intensity, and irreversible tissue alterations. Recent advances in deep learning have enabled…

Computer Vision and Pattern Recognition · Computer Science 2025-04-15 Ziwang Xu , Lanqing Guo , Satoshi Tsutsui , Shuyan Zhang , Alex C. Kot , Bihan Wen

Stain variation is a unique challenge associated with automated analysis of digital pathology. Numerous methods have been developed to improve the robustness of machine learning methods to stain variation, but comparative studies have…

Image and Video Processing · Electrical Eng. & Systems 2023-11-14 Michael Yeung , Todd Watts , Sean YW Tan , Pedro F. Ferreira , Andrew D. Scott , Sonia Nielles-Vallespin , Guang Yang

Cycle-Consistent Adversarial Network (CycleGAN) is very promising in domain adaptation. In this report, an example in medical domain will be explained. We present struecture of a CycleGAN model for unpaired image-to-image translation from…

Computer Vision and Pattern Recognition · Computer Science 2026-02-09 Yanhua Zhao

The problem of image-to-image translation is one that is intruiging and challenging at the same time, for the impact potential it can have on a wide variety of other computer vision applications like colorization, inpainting, segmentation…

Computer Vision and Pattern Recognition · Computer Science 2024-03-18 BahaaEddin AlAila , Zahra Jandaghi , Abolfazl Farahani , Mohammad Ziad Al-Saad

In this work, we study the problem of training deep networks for semantic image segmentation using only a fraction of annotated images, which may significantly reduce human annotation efforts. Particularly, we propose a strategy that…

Computer Vision and Pattern Recognition · Computer Science 2019-09-02 Arnab Kumar Mondal , Aniket Agarwal , Jose Dolz , Christian Desrosiers

Unsupervised image-to-image translation methods such as CycleGAN learn to convert images from one domain to another using unpaired training data sets from different domains. Unfortunately, these approaches still require centrally collected…

Computer Vision and Pattern Recognition · Computer Science 2021-06-18 Joonyoung Song , Jong Chul Ye

Staining is critical to cell imaging and medical diagnosis, which is expensive, time-consuming, labor-intensive, and causes irreversible changes to cell tissues. Recent advances in deep learning enabled digital staining via supervised model…

Image and Video Processing · Electrical Eng. & Systems 2023-03-06 Ziwang Xu , Lanqing Guo , Shuyan Zhang , Alex C. Kot , Bihan Wen

Domain shift in digital histopathology can occur when different stains or scanners are used, during stain translation, etc. A deep neural network trained on source data may not generalise well to data that has undergone some domain shift.…

Image and Video Processing · Electrical Eng. & Systems 2022-05-10 Zeeshan Nisar , Jelica Vasiljević , Pierre Gançarski , Thomas Lampert

Fully supervised segmentation methods require a large training cohort of already segmented images, providing information at the pixel level of each image. We present a method to automatically segment and model pathologies in medical images,…

Computer Vision and Pattern Recognition · Computer Science 2019-08-22 Simon Andermatt , Antal Horváth , Simon Pezold , Philippe Cattin

The process of digitising histology slides involves multiple factors that can affect a whole slide image's (WSI) final appearance, including the staining protocol, scanner, and tissue type. This variability constitutes a domain shift and…

Computer Vision and Pattern Recognition · Computer Science 2024-11-26 Manahil Raza , Saad Bashir , Talha Qaiser , Nasir Rajpoot

Large-scale synthetic datasets are beneficial to stereo matching but usually introduce known domain bias. Although unsupervised image-to-image translation networks represented by CycleGAN show great potential in dealing with domain gap, it…

Computer Vision and Pattern Recognition · Computer Science 2020-05-06 Rui Liu , Chengxi Yang , Wenxiu Sun , Xiaogang Wang , Hongsheng Li