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Laser Doppler holography (LDH) is a full-field blood flow imaging technique able to reveal human retinal and choroidal blood flow with high temporal resolution. We here report on using LDH in the anterior segment of the eye without making…

Laser Doppler holography (LDH) is a full-field imaging technique that was recently used in the human eye to reveal blood flow contrasts in the retinal and choroidal vasculature non-invasively, and with high temporal resolution. We here…

Medical Physics · Physics 2020-04-01 L. Puyo , M. Paques , M. Fink , J-A Sahel , M. Atlan

Laser Doppler holography (LDH) is a full-field interferometric imaging technique recently applied in ophthalmology to measure blood flow, a parameter of high clinical interest. From the temporal fluctuations of digital holograms acquired at…

Image and Video Processing · Electrical Eng. & Systems 2020-05-13 Leo Puyo , Michel Paques , Michael Atlan

Laser Doppler holography (LDH) is an interferometric blood flow imaging technique based on full-field measurements of the Doppler spectrum. LDH has so far been demonstrated in the retina with ultrafast cameras, typically at 75 kHz. We show…

Image and Video Processing · Electrical Eng. & Systems 2020-08-26 Leo Puyo , Michel Paques , Michael Atlan

A comprehensive assessment of retinal health demands reliable and precise methods to measure localized blood perfusion. Despite considerable advancements in imaging techniques, such as indocyanine green and fluorescein angiography, along…

Medical Physics · Physics 2024-03-15 Michael Atlan

Laser Doppler holography was introduced as a full-field imaging technique to measure blood flow in the retina and choroid with an as yet unrivaled temporal resolution. We here investigate separating the different contributions to the power…

Medical Physics · Physics 2021-06-02 Léo Puyo , Michel Paques , Mathias Fink , José-Alain Sahel , Michael Atlan

Laser Doppler holography is a planar blood flow imaging technique recently introduced in ophthalmology to image human retinal and choroidal blood flow non-invasively. Here we present a digital method based on the Doppler spectrum asymmetry…

Medical Physics · Physics 2021-08-10 Léo Puyo , Michel Paques , Michael Atlan

This study presents a novel quantitative estimation method for total retinal arterial blood flow utilizing real-time Doppler holography at an unprecedented frame rate of 33,000 frames per second. This technique, leveraging high-speed…

Image and Video Processing · Electrical Eng. & Systems 2024-09-27 Yann Fischer , Zacharie Auray , Olivier Martinache , Marius Dubosc , Noé Topéza , Chloé Magnier , Maxime Boy-Arnould , Michael Atlan

Corneal evaluation in ophthalmology necessitates cellular-resolution and fast imaging techniques allowing accurate diagnoses. Currently, the fastest volumetric imaging technique is Fourier-domain full-field optical coherence tomography…

We report on using a laser Doppler processing of Fourier-domain optical coherence tomography (OCT) data for the assessment of pulsatile blood flow in the choriocapillaris. Signal fluctuations in B-scans recorded at 2 kHz were analyzed by…

High-speed digital holography reveals local blood flow contrasts in the eye fundus through deterministic signal analysis, leveraging a forward scattering model of dynamically diffused light. This approach enables the estimation of absolute…

Instrumentation and Detectors · Physics 2025-05-14 Zacharie Auray , Yann Fischer , Olivier Martinache , Michael Atlan

Holographic optical coherence tomography (OCT) is a powerful imaging technique, but its ability to reveal low-reflectivity features is limited. In this study, we performed holographic OCT by incoherently averaging volumes with changing…

We performed non-invasive video imaging of retinal blood flow in a pigmented rat by holographic interferometry of near-infrared laser light backscattered by retinal tissue, beating against an off-axis reference beam sampled at a frame rate…

Instrumentation and Detectors · Physics 2016-07-27 Mathilde Pellizzari , Manuel Simonutti , Julie Degardin , Jose-Alain Sahel , Mathias Fink , Michel Paques , Michael Atlan

We report on local superficial blood flow monitoring in biological tissue from laser Doppler holographic imaging. In time averaging recording conditions, holography acts as a narrowband bandpass filter, which, combined with a frequency…

The eye offers a unique opportunity for non-invasive exploration of cardiovascular diseases. Optical angiography in the retina requires sensitive measurements, which hinders conventional full-field laser Doppler imaging schemes. To overcome…

Medical Physics · Physics 2018-09-18 L. Puyo , M. Paques , M. Fink , J. -A. Sahel , M. Atlan

We report on wide-field imaging of pulsatile motion induced by blood flow using heterodyne holographic interferometry on the thumb of a healthy volunteer, in real-time. Optical Doppler images were measured with green laser light by a…

This paper reports on advances in optical coherence tomography (OCT) for application in dermatology. Full-field OCT is a particular approach of OCT based on white-light interference microscopy. FF-OCT produces en face tomographic images by…

Medical Physics · Physics 2018-04-06 Olivier Levecq , Arthur Davis , Hicham Azimani , David Siret , Jean-Luc Perrot , Arnaud Dubois

This dissertation relates to the transition of the state of the art of swept source optical coherence tomography (SS-OCT) systems to a new realm in which the image acquisition speed is improved by an order of magnitude. With the aid of a…

Image and Video Processing · Electrical Eng. & Systems 2020-02-21 Amir Tofighi Zavareh

Traditional full-field optical coherence tomography (FF-OCT) is effective for rapid cross-sectional imaging but often suffers from incoherent signals due to imbalanced light intensities between the sample and reference arms. While the…

Optics · Physics 2024-10-17 Youlong Fan , Qingye Hu , Zhongping Wang , Zengming Zhang , Xiantao Wei

We report laser Doppler ophthalmoscopic fundus imaging in the rat eye with near-IR heterodyne holography. Sequential sampling of the beat of the reflected radiation against a frequency-shifted optical local oscillator is made onto an array…

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