This study presents a novel quantitative estimation method for total retinal arterial blood flow utilizing real-time Doppler holography at an unprecedented frame rate of 33,000 frames per second. This technique, leveraging high-speed digital holography, enables non-invasive angiographic imaging of the retina, providing detailed blood flow contrasts essential for assessing retinal health. The proposed quantitative analysis method consists of segmenting primary in-plane retinal arteries and calculating local blood velocity using Doppler frequency broadening. The analysis integrates a forward scattering model to achieve blood flow estimation. Our findings highlight the potential of Doppler holography as a powerful tool for diagnosing and monitoring the treatment of retinal vascular conditions, complementary to existing imaging methods.
@article{arxiv.2409.17180,
title = {Retinal arterial blood flow measured by real-time Doppler holography at 33,000 frames per second},
author = {Yann Fischer and Zacharie Auray and Olivier Martinache and Marius Dubosc and Noé Topéza and Chloé Magnier and Maxime Boy-Arnould and Michael Atlan},
journal= {arXiv preprint arXiv:2409.17180},
year = {2024}
}