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Microarray data analysis is one of the major area of research in the field computational biology. Numerous techniques like clustering, biclustering are often applied to microarray data to extract meaningful outcomes which play key roles in…

Neural and Evolutionary Computing · Computer Science 2019-09-04 Shubhankar Mohapatra , Moumita Sarkar , Anjali Mohapatra , Bhawani Sankar Biswal

Many clustering algorithms when the data are curves or functions have been recently proposed. However, the presence of contamination in the sample of curves can influence the performance of most of them. In this work we propose a robust,…

The identification of sets of co-regulated genes that share a common function is a key question of modern genomics. Bayesian profile regression is a semi-supervised mixture modelling approach that makes use of a response to guide inference…

The analysis of continously larger datasets is a task of major importance in a wide variety of scientific fields. In this sense, cluster analysis algorithms are a key element of exploratory data analysis, due to their easiness in the…

Machine Learning · Statistics 2018-01-10 Marco Capó , Aritz Pérez , Jose A. Lozano

We propose a new method for clustering of functional data using a $k$-means framework. We work within the elastic functional data analysis framework, which allows for decomposition of the overall variation in functional data into amplitude…

Methodology · Statistics 2020-11-26 Xiao Zang , Sebastian Kurtek , Oksana Chkrebtii , J. Derek Tucker

Over the last decade, a large variety of clustering algorithms have been developed to detect coregulatory relationships among genes from microarray gene expression data. Model based clustering approaches have emerged as statistically well…

Quantitative Methods · Quantitative Biology 2008-01-15 Anagha Joshi , Yves Van de Peer , Tom Michoel

Time-course gene expression data such as yeast cell cycle data may be periodically expressed. To cluster such data, currently used Fourier series approximations of periodic gene expressions have been found not to be sufficiently adequate to…

Methodology · Statistics 2011-09-23 K. Wang , S. K. Ng , G. J. McLachlan

Cluster analysis of biological samples using gene expression measurements is a common task which aids the discovery of heterogeneous biological sub-populations having distinct mRNA profiles. Several model-based clustering algorithms have…

Methodology · Statistics 2012-01-30 Alberto Cozzini , Ajay Jasra , Giovanni Montana

We develop a new method to locally cluster curves and discover functional motifs, i.e.~typical ``shapes'' that may recur several times along and across the curves capturing important local characteristics. In order to identify these shared…

Methodology · Statistics 2023-01-30 Marzia A. Cremona , Francesca Chiaromonte

Clustering is one of the main tasks in exploratory data analysis and descriptive statistics where the main objective is partitioning observations in groups. Clustering has a broad range of application in varied domains like climate,…

Databases · Computer Science 2012-03-20 Saptarsi Goswami , Amlan Chakrabarti

Microarray technology is a process that allows thousands of genes simultaneously monitor to various experimental conditions. It is used to identify the co-expressed genes in specific cells or tissues that are actively used to make proteins,…

Computational Engineering, Finance, and Science · Computer Science 2013-07-16 T. Chandrasekhar , K. Thangavel , E. Elayaraja

We study feature selection for $k$-means clustering. Although the literature contains many methods with good empirical performance, algorithms with provable theoretical behavior have only recently been developed. Unfortunately, these…

Machine Learning · Computer Science 2016-11-17 Christos Boutsidis , Malik Magdon-Ismail

A new method to sort gene expression patterns into functional groups is presented. The method is based on a sorting algorithm using a non-local similarity score, which takes all other patterns in the dataset into account. The method is…

Biological Physics · Physics 2007-05-23 Sven Bilke

Clustering analysis of functional data, which comprises observations that evolve continuously over time or space, has gained increasing attention across various scientific disciplines. Practical applications often involve functional data…

Methodology · Statistics 2024-06-19 Tingyu Zhu , Lan Xue , Carmen Tekwe , Keith Diaz , Mark Benden , Roger Zoh

In many fields, researchers are interested in large and complex biological processes. Two important examples are gene expression and DNA methylation in genetics. One key problem is to identify aberrant patterns of these processes and…

Applications · Statistics 2012-10-03 Matthias Kormaksson , James G. Booth , Maria E. Figueroa , Ari Melnick

Many biological processes display oscillatory behavior based on an approximately 24 hour internal timing system specific to each individual. One process of particular interest is gene expression, for which several circadian transcriptomic…

Applications · Statistics 2024-12-23 Michael Gorczyca , Tavish McDonald , Justice Sefas

Distributed data mining techniques and mainly distributed clustering are widely used in the last decade because they deal with very large and heterogeneous datasets which cannot be gathered centrally. Current distributed clustering…

Databases · Computer Science 2018-02-02 Malika Bendechache , M-Tahar Kechadi

In this work, the possibility of clustering correlated random variables was examined, both because of their mutual similarity and because of their similarity to the principal components. The k-means algorithm and spectral algorithms were…

Machine Learning · Computer Science 2019-09-10 Zenon Gniazdowski , Dawid Kaliszewski

Recently, it has become feasible to generate large-scale, multi-tissue gene expression data, where expression profiles are obtained from multiple tissues or organs sampled from dozens to hundreds of individuals. When traditional clustering…

Quantitative Methods · Quantitative Biology 2021-10-29 Pau Erola , Johan LM Björkegren , Tom Michoel

Recent technological developments have enabled us to collect complex and high-dimensional data in many scientific fields, such as population health, meteorology, econometrics, geology, and psychology. It is common to encounter such datasets…

Methodology · Statistics 2020-03-16 Ufuk Beyaztas , Han Lin Shang