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Understanding treatment effect heterogeneity is vital for scientific and policy research. However, identifying and evaluating heterogeneous treatment effects pose significant challenges due to the typically unknown subgroup structure.…

Methodology · Statistics 2024-11-05 Kwangho Kim , Jisu Kim , Larry A. Wasserman , Edward H. Kennedy

The expression levels of many thousands of genes can be measured simultaneously by DNA microarrays (chips). This novel experimental tool has revolutionized research in molecular biology and generated considerable excitement. A typical…

Biological Physics · Physics 2007-05-23 Eytan Domany

The problem of data clustering is one of the most important in data analysis. It can be problematic when dealing with experimental data characterized by measurement uncertainties and errors. Our paper proposes a recursive scheme for…

Machine Learning · Computer Science 2024-01-12 Alicja Miniak-Górecka , Krzysztof Podlaski , Tomasz Gwizdałła

Cluster analysis methods seek to partition a data set into homogeneous subgroups. It is useful in a wide variety of applications, including document processing and modern genetics. Conventional clustering methods are unsupervised, meaning…

Methodology · Statistics 2014-07-11 Eric Bair

We propose a statistical method for clustering of multivariate longitudinal data into homogeneous groups. This method relies on a time-varying extension on the classical K-means algorithm, where a multivariate vector autoregressive model is…

Methodology · Statistics 2014-04-25 Antonello Maruotti , Maurizio Vichi

Clustering is a difficult and widely-studied data mining task, with many varieties of clustering algorithms proposed in the literature. Nearly all algorithms use a similarity measure such as a distance metric (e.g. Euclidean distance) to…

Neural and Evolutionary Computing · Computer Science 2019-10-24 Andrew Lensen , Bing Xue , Mengjie Zhang

In microarray experiments, it is often of interest to identify genes which have a pre-specified gene expression profile with respect to time. Methods available in the literature are, however, typically not stringent enough in identifying…

Applications · Statistics 2009-01-18 J. Tuke , G. F. V. Glonek , P. J. Solomon

Feature selection is an important and challenging task in high dimensional clustering. For example, in genomics, there may only be a small number of genes that are differentially expressed, which are informative to the overall clustering…

Methodology · Statistics 2019-10-07 Xiangrui Zeng , Hongyu Zheng

Microarrays are made it possible to simultaneously monitor the expression profiles of thousands of genes under various experimental conditions. It is used to identify the co-expressed genes in specific cells or tissues that are actively…

Machine Learning · Computer Science 2012-03-15 T. Chandrasekhar , K. Thangavel , E. Elayaraja

Functional data analysis involves data described by regular functions rather than by a finite number of real valued variables. While some robust data analysis methods can be applied directly to the very high dimensional vectors obtained…

Machine Learning · Statistics 2012-01-06 Fabrice Rossi , Yves Lechevallier

Discrete mixture models provide a well-known basis for effective clustering algorithms, although technical challenges have limited their scope. In the context of gene-expression data analysis, a model is presented that mixes over a finite…

Methodology · Statistics 2012-11-12 Michael A. Newton , Lisa M. Chung

Recent studies show that ensemble methods enhance the stability and robustness of unsupervised learning. These approaches are successfully utilized to construct multiple clustering and combine them into a one representative consensus…

Neural and Evolutionary Computing · Computer Science 2018-06-01 Elaheh Rashedi , Abdolreza Mirzaei

Purpose: Functional Magnetic Resonance Imaging (fMRI) data acquired through resting-state studies have been used to obtain information about the spontaneous activations inside the brain. One of the approaches for analysis and interpretation…

Image and Video Processing · Electrical Eng. & Systems 2022-02-24 Harshit Parmar , Brian Nutter , Rodney Long , Sameer Antani , Sunanda Mitra

To cluster data that are not linearly separable in the original feature space, $k$-means clustering was extended to the kernel version. However, the performance of kernel $k$-means clustering largely depends on the choice of kernel…

Machine Learning · Computer Science 2018-11-02 Yaqiang Yao , Huanhuan Chen

Existing clustering methods for functional data often prioritize partitioning accuracy over interpretability, making it challenging to extract meaningful insights when the data-generating process follows a specific underlying structure and…

Clustering, a fundamental activity in unsupervised learning, is notoriously difficult when the feature space is high-dimensional. Fortunately, in many realistic scenarios, only a handful of features are relevant in distinguishing clusters.…

Machine Learning · Statistics 2020-10-23 Zhiyue Zhang , Kenneth Lange , Jason Xu

A new procedure for simultaneously finding the optimal cluster structure of multivariate functional objects and finding the subspace to represent the cluster structure is presented. The method is based on the $k$-means criterion for…

Methodology · Statistics 2014-02-11 Michio Yamamoto , Yoshikazu Terada

Identifying the number $K$ of clusters in a dataset is one of the most difficult problems in clustering analysis. A choice of $K$ that correctly characterizes the features of the data is essential for building meaningful clusters. In this…

Methodology · Statistics 2019-05-06 Adriano Zanin Zambom , Julian A. Collazos , Ronaldo Dias

Modelling and forecasting homogeneous age-specific mortality rates of multiple countries could lead to improvements in long-term forecasting. Data fed into joint models are often grouped according to nominal attributes, such as geographic…

Methodology · Statistics 2022-01-05 Chen Tang , Han Lin Shang , Yanrong Yang

Although there is no shortage of clustering algorithms proposed in the literature, the question of the most relevant strategy for clustering compositional data (i.e., data made up of profiles, whose rows belong to the simplex) remains…

Statistics Theory · Mathematics 2018-05-17 Antoine Godichon-Baggioni , Cathy Maugis-Rabusseau , Andrea Rau