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Nuclei instance segmentation on histopathology images is of great clinical value for disease analysis. Generally, fully-supervised algorithms for this task require pixel-wise manual annotations, which is especially time-consuming and…

Computer Vision and Pattern Recognition · Computer Science 2023-06-06 Yang Zhou , Yongjian Wu , Zihua Wang , Bingzheng Wei , Maode Lai , Jianzhong Shou , Yubo Fan , Yan Xu

Accurate segmentation of medical images is essential for diagnosis and treatment of diseases. These problems are solved by highly complex models, such as deep networks (DN), requiring a large amount of labeled data for training. Thereby,…

Image and Video Processing · Electrical Eng. & Systems 2022-04-15 Dario Sitnik , Ivica Kopriva

Cell detection, segmentation and classification are essential for analyzing tumor microenvironments (TME) on hematoxylin and eosin (H&E) slides. Existing methods suffer from poor performance on understudied cell types (rare or not present…

Automated semantic segmentation of whole-slide images (WSIs) stained with hematoxylin and eosin (H&E) is essential for large-scale artificial intelligence-based biomarker analysis in breast cancer. However, existing public datasets for…

Automatic nuclei detection and classification can produce effective information for disease diagnosis. Most existing methods classify nuclei independently or do not make full use of the semantic similarity between nuclei and their grouping…

Computer Vision and Pattern Recognition · Computer Science 2023-10-24 Junjia Huang , Haofeng Li , Weijun Sun , Xiang Wan , Guanbin Li

Nuclei instance segmentation is an essential task in pathology image analysis, serving as the foundation for many downstream applications. The release of several public datasets has significantly advanced research in this area, yet many…

Image and Video Processing · Electrical Eng. & Systems 2025-08-22 Jiamu Wang , Jin Tae Kwak

Best performing nuclear segmentation methods are based on deep learning algorithms that require a large amount of annotated data. However, collecting annotations for nuclear segmentation is a very labor-intensive and time-consuming task.…

Quantitative Methods · Quantitative Biology 2019-09-10 Mostafa Jahanifar , Navid Alemi Koohbanani , Nasir Rajpoot

Classifying the various shapes and attributes of a glioma cell nucleus is crucial for diagnosis and understanding the disease. We investigate automated classification of glioma nuclear shapes and visual attributes using Convolutional Neural…

Computer Vision and Pattern Recognition · Computer Science 2017-01-11 Veda Murthy , Le Hou , Dimitris Samaras , Tahsin M. Kurc , Joel H. Saltz

Early detection and prognosis of breast cancer are feasible by utilizing histopathological grading of biopsy specimens. This research is focused on detection and grading of nuclear pleomorphism in histopathological images of breast cancer.…

Computer Vision and Pattern Recognition · Computer Science 2016-12-06 Pegah Faridi , Habibollah Danyali , Mohammad Sadegh Helfroush , Mojgan Akbarzadeh Jahromi

Different convolutional neural network (CNN) models have been tested for their application in histological image analyses. However, these models are prone to overfitting due to their large parameter capacity, requiring more data or valuable…

Breast cancer is a leading cause of cancer-related mortality worldwide, and timely accurate diagnosis is critical to improving survival outcomes. While convolutional neural networks (CNNs) have demonstrated strong performance on…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Aditya Shribhagwan Khandelwal , Mohammad Samar Ansari , Asra Aslam

Deep learning-based nuclei segmentation and classification in pathology images typically rely on large-scale pixel-level manual annotations, which are costly and difficult to obtain across diverse tissues and staining conditions. To address…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Kazuya Nishimura , Ryoma Bise , Haruka Hirose , Yasuhiro Kojima

Numerous deep learning based methods have been developed for nuclei segmentation for H&E images and have achieved close to human performance. However, direct application of such methods to another modality of images, such as…

Computer Vision and Pattern Recognition · Computer Science 2022-08-15 Roger Trullo , Quoc-Anh Bui , Qi Tang , Reza Olfati-Saber

The presence of certain clinical dermoscopic features within a skin lesion may indicate melanoma, and automatically detecting these features may lead to more quantitative and reproducible diagnoses. We reformulate the task of classifying…

Computer Vision and Pattern Recognition · Computer Science 2019-03-28 Jeremy Kawahara , Ghassan Hamarneh

Accurate identification and localisation of brain tumours from medical images remain challenging due to tumour variability and structural complexity. Convolutional Neural Networks (CNNs), particularly ResNet and Unet, have made significant…

Image and Video Processing · Electrical Eng. & Systems 2024-12-31 Peixin Dai , Jingsi Zhang , Zhitao Shu

Prostate cancer (PCa) is graded by pathologists by examining the architectural pattern of cancerous epithelial tissue on hematoxylin and eosin (H&E) stained slides. Given the importance of gland morphology, automatically differentiating…

Medical image segmentation typically adopts a point-wise convolutional segmentation head to predict dense labels, where each output channel is heuristically tied to a specific class. This rigid design limits both feature sharing and…

Computer Vision and Pattern Recognition · Computer Science 2025-11-20 Bin Xie , Gady Agam

The medical image is characterized by the inter-class indistinction, high variability, and noise, where the recognition of pixels is challenging. Unlike previous self-attention based methods that capture context information from one level,…

Computer Vision and Pattern Recognition · Computer Science 2019-11-26 Fei Ding , Gang Yang , Jinlu Liu , Jun Wu , Dayong Ding , Jie Xv , Gangwei Cheng , Xirong Li

Nuclei segmentation and classification is the first and most crucial step that is utilized for many different microscopy medical analysis applications. However, it suffers from many issues such as the segmentation of small objects,…

Image and Video Processing · Electrical Eng. & Systems 2022-03-07 Hussam Azzuni , Muhammad Ridzuan , Min Xu , Mohammad Yaqub

Blood vessels (BVs) play a critical role in the Tumor Micro-Environment (TME), potentially influencing cancer progression and treatment response. However, manually quantifying BVs in Hematoxylin and Eosin (H&E) stained images is challenging…

Image and Video Processing · Electrical Eng. & Systems 2025-01-27 Jiaqi Lv , Stefan S Antonowicz , Shan E Ahmed Raza