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Critical goals of scientific computing are to increase scientific rigor, reproducibility, and transparency while keeping up with ever-increasing computational demands. This work presents an integrated framework well-suited for data…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-10-13 Paul Nuyujukian

To increase performance and efficiency, systems use FPGAs as reconfigurable accelerators. A key challenge in designing these systems is partitioning computation between processors and an FPGA. An appropriate division of labor may be…

Hardware Architecture · Computer Science 2021-07-21 Endri Bezati , Mahyar Emami , Jörn Janneck , James Larus

Lakehouses are now the default substrate for analytics and AI, but they remain fragile under concurrent, untrusted change: schema mismatches often surface only at runtime, development and production easily diverge, and multi-table pipelines…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-03-18 Weiming Sheng , Jinlang Wang , Manuel Barros , Aldrin Montana , Jacopo Tagliabue , Luca Bigon

In year 2006 Bio-Linux with the work of Tim Booth and team gives its rising and provide an operating system that was and still specialized in providing a bioinformatic specific software environment for the working needs in this corner of…

Operating Systems · Computer Science 2013-10-08 Sasa Paporovic

As spatial and temporal resolutions of scientific instruments improve, the explosion in the volume of data produced is becoming a key challenge. It can be a critical bottleneck for integration between scientific instruments at the edge and…

Instrumentation and Detectors · Physics 2021-11-03 Kazutomo Yoshii , Rajesh Sankaran , Sebastian Strempfer , Maksim Levental , Mike Hammer , Antonino Miceli

The current trend for domain-specific architectures (DSAs) has led to renewed interest in research test chips to demonstrate new specialized hardware. Tape-outs also offer huge pedagogical value garnered from real hands-on exposure to the…

Hardware Architecture · Computer Science 2020-05-27 Paul Whatmough , Marco Donato , Glenn Ko , Sae-Kyu Lee , David Brooks , Gu-Yeon Wei

This paper aims to create a transition path from file-based IO to streaming-based workflows for scientific applications in an HPC environment. By using the openPMP-api, traditional workflows limited by filesystem bottlenecks can be overcome…

The ubiquity of computation in modern scientific research inflicts new challenges for reproducibility. While most journals now require code and data be made available, the standards for organization, annotation, and validation remain lax,…

Other Quantitative Biology · Quantitative Biology 2022-10-07 Griffin Chure

Omics software tools have reshaped the landscape of modern biology and become an essential component of biomedical research. The increasing dependence of biomedical scientists on these powerful tools creates a need for easier installation…

To reduce the carbon footprint of computing and stabilize electricity grids, there is an increasing focus on approaches that align the power usage of IT infrastructure with the availability of clean energy. Unfortunately, research on…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-06-21 Philipp Wiesner , Ilja Behnke , Paul Kilian , Marvin Steinke , Odej Kao

When designing new web applications, developers must cope with different kinds of constraints relative to the resources they rely on: software, hardware, network, online micro-services, or any combination of the mentioned entities.…

Programming Languages · Computer Science 2026-02-06 Anna Gallone , Simon Bliudze , Sophie Cerf , Olga Kouchnarenko

Time-series learning is the bread and butter of data-driven *clinical decision support*, and the recent explosion in ML research has demonstrated great potential in various healthcare settings. At the same time, medical time-series problems…

Machine Learning · Computer Science 2023-10-31 Daniel Jarrett , Jinsung Yoon , Ioana Bica , Zhaozhi Qian , Ari Ercole , Mihaela van der Schaar

Proof autoformalization, the task of translating natural language theorems and proofs into machine-verifiable code, is a critical step for integrating large language models into rigorous mathematical workflows. Current approaches focus on…

Artificial Intelligence · Computer Science 2025-10-21 Rafael Cabral , Tuan Manh Do , Xuejun Yu , Wai Ming Tai , Zijin Feng , Xin Shen

Building multiscale biological models requires integrating independently developed submodels, which involves sharing variables and coordinating execution. Most existing tools focus on isolated mechanisms and numerical methods, but rarely…

Quantitative Methods · Quantitative Biology 2026-01-01 Eran Agmon , Ryan K Spangler

Logs are a common way to record detailed run-time information in software. As modern software systems evolve in scale and complexity, logs have become indispensable to understanding the internal states of the system. At the same time…

Machine Learning · Computer Science 2021-03-15 Armin Catovic , Carolyn Cartwright , Yasmin Tesfaldet Gebreyesus , Simone Ferlin

Difficulty replicating baselines, high computational costs, and required domain expertise create persistent barriers to clinical AI research. To address these challenges, we introduce PyHealth 2.0, an enhanced clinical deep learning toolkit…

Successful data-driven science requires complex data engineering pipelines to clean, transform, and alter data in preparation for machine learning, and robust results can only be achieved when each step in the pipeline can be justified, and…

Databases · Computer Science 2024-04-08 Adriane Chapman , Luca Lauro , Paolo Missier , Riccardo Torlone

Unorganized heaps of analysis code are a growing liability as data analysis pipelines are getting longer and more complicated. This is worrying, as neuroscience papers are getting retracted due to programmer error. In this paper, some…

Software Engineering · Computer Science 2019-08-12 Marijn van Vliet

The increasing risk of epidemics and a fast-growing world population has contributed to a great investment in phylogenetic analysis, in order to track numerous diseases and conceive effective medication and treatments. Phylogenetic analysis…

Social and Information Networks · Computer Science 2022-11-29 Miguel Luis , Catia Vaz

In year 2006 Biolinux inter alia with the work of Tim Booth gives its rise and provide an operating system that was and is specialized in providing an environment for the needs of bioinformatics. Since than some years have been seen and the…

Computers and Society · Computer Science 2013-05-21 Sasa Paporovic