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Treatment planning in low-dose-rate prostate brachytherapy (LDR-PB) aims to produce arrangement of implantable radioactive seeds that deliver a minimum prescribed dose to the prostate whilst minimizing toxicity to healthy tissues. There can…

Computer Vision and Pattern Recognition · Computer Science 2022-05-10 Tajwar Abrar Aleef , Ingrid T. Spadinger , Michael D. Peacock , Septimiu E. Salcudean , S. Sara Mahdavi

Optimizing metamaterials with complex geometries is a big challenge. Although an active learning algorithm, combining machine learning (ML), quantum computing, and optical simulation, has emerged as an efficient optimization tool, it still…

Quantum Physics · Physics 2024-05-06 Seongmin Kim , In-Saeng Suh

Liver infection is a common disease, which poses a great threat to human health, but there is still able to identify an optimal technique that can be used on large-level screening. This paper deals with ML algorithms using different data…

Machine Learning · Computer Science 2023-05-16 P. Deivendran , S. Selvakanmani , S. Jegadeesan , V. Vinoth Kumar

We study capacity- and budget-constrained multi-agent MDPs (CB-MA-MDPs), a class that captures many maintenance and scheduling tasks in which each agent can irreversibly fail and a planner must decide (i) when to apply a restorative action…

Machine Learning · Computer Science 2025-10-08 Manav Vora , Ilan Shomorony , Melkior Ornik

In radiation therapy, mathematical methods have been used for optimizing treatment planning for delivery of sufficient dose to the cancerous cells while keeping the dose to critical surrounding structures minimal. This optimization problem…

Medical Physics · Physics 2015-06-16 Hamed Yarmand , David Craft

Kinodynamic Motion Planning (KMP) is to find a robot motion subject to concurrent kinematics and dynamics constraints. To date, quite a few methods solve KMP problems and those that exist struggle to find near-optimal solutions and exhibit…

Robotics · Computer Science 2021-01-19 Linjun Li , Yinglong Miao , Ahmed H. Qureshi , Michael C. Yip

Multi-agent path finding (MAPF) in large networks is computationally challenging. An approach for MAPF is prioritized planning (PP), in which agents plan sequentially according to their priority. Albeit a computationally efficient approach…

Multiagent Systems · Computer Science 2025-01-22 Patrick Scheffe , Julius Kahle , Bassam Alrifaee

Purpose: To improve the delivery efficiency of VMAT by extending the recently published VMAT treatment planning algorithm vmerge to automatically generate optimal partial-arc plans. Methods and materials: A high-quality initial plan is…

Medical Physics · Physics 2015-06-05 Jeremiah Wala , Ehsan Salari , Wei Chen , David Craft

Machine learning algorithms have been used widely in various applications and areas. To fit a machine learning model into different problems, its hyper-parameters must be tuned. Selecting the best hyper-parameter configuration for machine…

Machine Learning · Computer Science 2022-10-06 Li Yang , Abdallah Shami

Hyperparameter optimization (HPO) is a necessary step to ensure the best possible performance of Machine Learning (ML) algorithms. Several methods have been developed to perform HPO; most of these are focused on optimizing one performance…

Machine Learning · Computer Science 2022-11-16 Alejandro Morales-Hernández , Inneke Van Nieuwenhuyse , Sebastian Rojas Gonzalez

Several recent publications report advances in training optimal decision trees (ODT) using mixed-integer programs (MIP), due to algorithmic advances in integer programming and a growing interest in addressing the inherent suboptimality of…

Machine Learning · Computer Science 2020-11-09 Haoran Zhu , Pavankumar Murali , Dzung T. Phan , Lam M. Nguyen , Jayant R. Kalagnanam

Rheumatoid arthritis (RA) is an autoimmune condition caused when patients' immune system mistakenly targets their own tissue. Machine learning (ML) has the potential to identify patterns in patient electronic health records (EHR) to…

Quantitative Methods · Quantitative Biology 2022-10-25 Shengjia Chen , Nikunj Gupta , Woodward B. Galbraith , Valay Shah , Jacopo Cirrone

Hyperparameters are configuration variables controlling the behavior of machine learning algorithms. They are ubiquitous in machine learning and artificial intelligence and the choice of their values determines the effectiveness of systems…

Proton pencil beam scanning (PBS) treatment planning for head & neck (H&N) cancers involves numerous conflicting objectives, requiring iterative objective parameter adjustments to balance multiple clinical goals. We propose a…

Artificial Intelligence · Computer Science 2025-09-16 Qingqing Wang , Liqiang Xiao , Chang Chang

Identifying and selecting high-quality Metamorphic Relations (MRs) is a challenge in Metamorphic Testing (MT). While some techniques for automatically selecting MRs have been proposed, they are either domain-specific or rely on strict…

Software Engineering · Computer Science 2024-01-05 Alejandra Duque-Torres , Dietmar Pfahl , Claus Klammer , Stefan Fischer

The goal of uplift modeling is to recommend actions that optimize specific outcomes by determining which entities should receive treatment. One common approach involves two steps: first, an inference step that estimates conditional average…

Machine Learning · Computer Science 2025-05-21 Simon De Vos , Christopher Bockel-Rickermann , Stefan Lessmann , Wouter Verbeke

The performance of any Machine Learning (ML) algorithm is impacted by the choice of its hyperparameters. As training and evaluating a ML algorithm is usually expensive, the hyperparameter optimization (HPO) method needs to be…

Machine Learning · Computer Science 2022-09-12 Alejandro Morales-Hernández , Inneke Van Nieuwenhuyse , Gonzalo Nápoles

A number of image-processing problems can be formulated as optimization problems. The objective function typically contains several terms specifically designed for different purposes. Parameters in front of these terms are used to control…

Medical Physics · Physics 2017-11-02 Chenyang Shen , Yesenia Gonzalez , Liyuan Chen , Steve B. Jiang , Xun Jia

Imbalanced problems are prevalent in various real-world scenarios and are extensively explored in classification tasks. However, they also present challenges for regression tasks due to the rarity of certain target values. A common…

Machine Learning · Computer Science 2025-07-17 Juscimara G. Avelino , George D. C. Cavalcanti , Rafael M. O. Cruz

Robust optimization is a commonly employed method to mitigate uncertainties in the planning of intensity-modulated proton therapy (IMPT). In certain contexts, the large number of uncertainty scenarios makes the robust problem impractically…

Medical Physics · Physics 2025-04-22 Ivar Bengtsson
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