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Related papers: Meta-optimization for Fully Automated Radiation Th…

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Radiotherapy (RT) is a critical cancer treatment, with volumetric modulated arc therapy (VMAT) being a commonly used technique that enhances dose conformity by dynamically adjusting multileaf collimator (MLC) positions and monitor units…

Medical Physics · Physics 2025-06-26 Stefanos Achlatis , Efstratios Gavves , Jan-Jakob Sonke

In a treatment plan optimization problem for radiotherapy, a clinically acceptable plan is usually generated by an optimization process with weighting factors or reference doses adjusted for organs. Recent discoveries indicate that…

Medical Physics · Physics 2012-10-29 Masoud Zarepisheh , Andres F. Uribe-Sanchez , Nan Li , Xun Jia , Steve B. Jiang

Deep learning-based automated contouring and treatment planning has been proven to improve the efficiency and accuracy of radiotherapy. However, conventional radiotherapy treatment planning process has the automated contouring and treatment…

Medical Physics · Physics 2024-12-02 Sangwook Kim , Aly Khalifa , Thomas G. Purdie , Chris McIntosh

Recent advancements in large language models (LLMs) have enabled LLM-based agents to successfully tackle interactive planning tasks. However, despite their successes, existing approaches often suffer from planning hallucinations and require…

Computation and Language · Computer Science 2025-09-11 Weimin Xiong , Yifan Song , Qingxiu Dong , Bingchan Zhao , Feifan Song , Xun Wang , Sujian Li

The modern workflow for radiation therapy treatment planning involves mathematical optimization to determine optimal treatment machine parameters for each patient case. The optimization problems can be computationally expensive, requiring…

Mathematical Software · Computer Science 2023-05-30 Felix Liu , Måns I. Andersson , Albin Fredriksson , Stefano Markidis

Recent works in automated radiotherapy treatment planning have used machine learning based on historical treatment plans to infer the spatial dose distribution for a novel patient directly from the planning image. We present an atlas-based…

Medical Physics · Physics 2017-08-02 Chris McIntosh , Mattea Welch , Andrea McNiven , David A. Jaffray , Thomas G. Purdie

The problem of chemotherapy treatment optimization can be defined in order to minimize the size of the tumor without endangering the patient's health; therefore, chemotherapy requires to achieve a number of objectives, simultaneously. For…

Neural and Evolutionary Computing · Computer Science 2023-03-21 Mina Jafari , Behnam Ghavami , Vahid Sattari Naeini

Automated machine learning aims to automate the whole process of machine learning, including model configuration. In this paper, we focus on automated hyperparameter optimization (HPO) based on sequential model-based optimization (SMBO).…

Machine Learning · Computer Science 2019-09-11 Ying Wei , Peilin Zhao , Huaxiu Yao , Junzhou Huang

We apply the recently proposed superiorization methodology (SM) to the inverse planning problem in radiation therapy. The inverse planning problem is represented here as a constrained minimization problem of the total variation (TV) of the…

Optimization and Control · Mathematics 2014-02-07 R. Davidi , Y. Censor , R. W. Schulte , S. Geneser , L. Xing

Recent shifts in global health priorities have positioned Population Health Management (PHM) as a central area of focus. However, optimizing PHM strategies presents several challenges: managing high-dimensional patient covariates, tracking…

Optimization and Control · Mathematics 2026-04-10 Daniel Adelman , Alba V Olivares-Nadal , Miaolan Xie

Background: Parkinson's disease (PD) is a prevalent long-term neurodegenerative disease. Though the diagnostic criteria of PD are relatively well defined, the current medical imaging diagnostic procedures are expertise-demanding, and thus…

Quantitative Methods · Quantitative Biology 2019-02-27 Jiahang Xu , Fangyang Jiao , Yechong Huang , Xinzhe Luo , Qian Xu , Ling Li , Xueling Liu , Chuantao Zuo , Ping Wu , Xiahai Zhuang

High-dose-rate (HDR) brachytherapy plays a critical role in the treatment of locally advanced cervical cancer but remains highly dependent on manual treatment planning expertise. The objective of this study is to develop a fully automated…

One primary goal of precision medicine is to estimate the individualized treatment rules (ITRs) that optimize patients' health outcomes based on individual characteristics. Health studies with multiple treatments are commonly seen in…

Methodology · Statistics 2025-05-07 Xuqiao Li , Qiuyan Zhou , Ying Wu , Ying Yan

High dose-rate brachytherapy (HDRBT) is widely used for gynecological cancer treatment. Although commercial treatment planning systems (TPSs) have inverse optimization modules, it takes several iterations to adjust planning objectives to…

Medical Physics · Physics 2021-09-14 Huan Liu , Chang M Ma , Xun Jia , Chenyang Shen , Peter Klages , Kevin Albuquerque

We apply the superiorization methodology to the intensity-modulated radiation therapy (IMRT) treatment planning problem. In superiorization, linear voxel dose inequality constraints are the fundamental modeling tool within which a…

Medical Physics · Physics 2022-07-28 Florian Barkmann , Yair Censor , Niklas Wahl

Multi-robot systems offer enhanced capability over their monolithic counterparts, but they come at a cost of increased complexity in coordination. To reduce complexity and to make the problem tractable, multi-robot motion planning (MRMP)…

Robotics · Computer Science 2021-11-30 Changrak Choi , Muhammad Adil , Amir Rahmani , Ramtin Madani

Most machine learning algorithms are configured by one or several hyperparameters that must be carefully chosen and often considerably impact performance. To avoid a time consuming and unreproducible manual trial-and-error process to find…

Intelligent interaction with the real world requires robotic agents to jointly reason over high-level plans and low-level controls. Task and motion planning (TAMP) addresses this by combining symbolic planning and continuous trajectory…

Robotics · Computer Science 2025-09-18 Denis Shcherba , Eckart Cobo-Briesewitz , Cornelius V. Braun , Marc Toussaint

Hyper-parameter optimization is one of the most tedious yet crucial steps in training machine learning models. There are numerous methods for this vital model-building stage, ranging from domain-specific manual tuning guidelines suggested…

Machine Learning · Computer Science 2023-03-08 Ahmad Esmaeili , Zahra Ghorrati , Eric T. Matson

Current radiation therapy treatment planning is limited by suboptimal plan quality, inefficiency, and high costs. This perspective paper explores the complexity of treatment planning and introduces Human-Centric Intelligent Treatment…

Medical Physics · Physics 2025-10-16 Adnan Jafar , Xun Jia