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Single-cell organisms and various cell types use a range of motility modes when following a chemical gradient, but it is unclear which mode is best suited for different gradients. Here, we model directional decision-making in chemotactic…

Cell Behavior · Quantitative Biology 2025-05-12 Albert Alonso , Julius B. Kirkegaard , Robert G. Endres

Artificial Intelligence Virtual Cells (AIVCs) aim to learn executable, decision-relevant models of cell state from multimodal, multiscale measurements. Recent studies have introduced single-cell and spatial foundation models, improved…

Artificial Intelligence · Computer Science 2025-12-03 Chengpeng Hu , Calvin Yu-Chian Chen

Animal groups collaborate with one another throughout their lives to better comprehend their surroundings. Here, we try to model, using continuous random walks, how the entire process of birth, reproduction, and death might impact the…

Adaptation and Self-Organizing Systems · Physics 2022-11-07 Sanchayan Bhowal , Ramkrishna Jyoti Samanta , Arnob Ray , Sirshendu Bhattacharyya , Chittaranjan Hens

As artificial intelligence systems move toward clinical deployment, ensuring reliable prediction behavior is fundamental for safety-critical decision-making tasks. One proposed safeguard is selective prediction, where models can defer…

Machine Learning · Computer Science 2026-05-25 L. Julián Lechuga López , Farah E. Shamout , Tim G. J. Rudner

Instance segmentation has witnessed promising advancements through deep neural network-based algorithms. However, these models often exhibit incorrect predictions with unwarranted confidence levels. Consequently, evaluating prediction…

Computer Vision and Pattern Recognition · Computer Science 2023-09-20 Qasim M. K. Siddiqui , Sebastian Starke , Peter Steinbach

Decades of research suggest that information exchange in groups and organizations can reliably improve judgment accuracy in tasks such as financial forecasting, market research, and medical decision-making. However, we show that improving…

General Economics · Economics 2021-04-26 Joshua Becker , Douglas Guilbeault , Ned Smith

Many similarity-based clustering methods work in two separate steps including similarity matrix computation and subsequent spectral clustering. However, similarity measurement is challenging because it is usually impacted by many factors,…

Machine Learning · Computer Science 2017-05-04 Zhao Kang , Chong Peng , Qiang Cheng

Calibration refers to the estimation of unknown parameters which are present in computer experiments but not available in physical experiments. An accurate estimation of these parameters is important because it provides a scientific…

Methodology · Statistics 2019-03-21 Chih-Li Sung , Ying Hung , William Rittase , Cheng Zhu , C. F. Jeff Wu

We develop of a line of work initiated by Curto and Itskov towards understanding the amount of information contained in the spike trains of hippocampal place cells via topology considerations. Previously, it was established that simply…

Neurons and Cognition · Quantitative Biology 2018-11-21 Samir Chowdhury , Bowen Dai , Facundo Mémoli

The spatial structure of the cell is highly organized at all levels: from small complexes and assemblies, to local nano- and micro-clusters, to global, micrometer scales across and between cells. We suggest that this multiscale spatial cell…

Biomolecules · Quantitative Biology 2013-08-06 Ruth Nussinov

Models are expected to engage in invariance learning, which involves distinguishing the core relations that remain consistent across varying environments to ensure the predictions are safe, robust and fair. While existing works consider…

Machine Learning · Computer Science 2025-03-11 Yang Xu , Yihong Gu , Cong Fang

Living organisms survive and multiply even though they have uncertain and incomplete information about their environment and imperfect models to predict the consequences of their actions. Bayesian models have been proposed to face this…

Emerging Technologies · Computer Science 2015-11-13 Jacques Droulez , David Colliaux , Audrey Houillon , Pierre Bessière

We consider clustering in group decision making where the opinions are given by pairwise comparison matrices. In particular, the k-medoids model is suggested to classify the matrices since it has a linear programming problem formulation…

Optimization and Control · Mathematics 2025-04-17 Kolos Csaba Ágoston , Sándor Bozóki , László Csató

Emergent communication offers insight into how agents develop shared structured representations, yet most research assumes homogeneous modalities or aligned representational spaces, overlooking the perceptual heterogeneity of real-world…

Multiagent Systems · Computer Science 2026-01-30 Naomi Pitzer , Daniela Mihai

Currently, data-driven discovery in biological sciences resides in finding segmentation strategies in multivariate data that produce sensible descriptions of the data. Clustering is but one of several approaches and sometimes falls short…

Quantitative Methods · Quantitative Biology 2022-08-12 Richard Tjörnhammar

Previous gait recognition methods primarily trained on labeled datasets, which require painful labeling effort. However, using a pre-trained model on a new dataset without fine-tuning can lead to significant performance degradation. So to…

Computer Vision and Pattern Recognition · Computer Science 2024-12-10 Xuqian Ren , Shaopeng Yang , Saihui Hou , Chunshui Cao , Xu Liu , Yongzhen Huang

Complex systems show the capacity to aggregate information and to display coordinated activity. In the case of social systems the interaction of different individuals leads to the emergence of norms, trends in political positions, opinions,…

Physics and Society · Physics 2016-04-25 Toni Pérez , Jordi Zamora , Víctor M. Eguíluz

To adapt their behaviour in changing environments, cells sense concentrations by binding external ligands to their receptors. However, incorrect ligands may bind nonspecifically to receptors, and when their concentration is large, this…

Molecular Networks · Quantitative Biology 2015-07-23 Thierry Mora

Neural networks are trained primarily based on their inputs and outputs, without regard for their internal mechanisms. These neglected mechanisms determine properties that are critical for safety, like (i) transparency; (ii) the absence of…

Machine Learning · Computer Science 2024-12-02 Alex Cloud , Jacob Goldman-Wetzler , Evžen Wybitul , Joseph Miller , Alexander Matt Turner

Living organisms process information to interact and adapt to their changing environment with the goal of finding food, mates or averting hazards. The structure of their niche has profound repercussions by both selecting their internal…

Physics and Society · Physics 2017-06-07 Hannes Hornischer , Stephan Herminghaus , Marco G. Mazza