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Optoacoustic tomography (OAT) is a promising modality for breast cancer diagnosis because tumor angiogenesis and, potentially, hypoxia can be visualized using quantitative OAT (qOAT) techniques. Clinically meaningful inference generally…

Medical Physics · Physics 2025-10-02 Seonyeong Park , Gangwon Jeong , Umberto Villa , Mark A. Anastasio

As an emerging medical diagnostic technology, photoacoustic imaging has been implemented for both preclinical and clinical applications. For clinical convenience, a handheld free scan photoacoustic tomography (PAT) system providing 3D…

Medical Physics · Physics 2022-03-18 Daohuai Jiang , Hongbo Chen , Yuting Shen , Yifan Zhang , Feng Gao , Rui Zheng , Fei Gao

Photoacoustic imaging (PAI) is a powerful imaging modality that relies on the PA effect. PAI works on the principle of electromagnetic energy absorption by the exogenous contrast agents and/or endogenous molecules present in the biological…

Optics · Physics 2020-12-16 Mohsin Zafar , Qiuyun Xu , Rayyan Manwar

We present a photoacoustic computed tomography investigation on a healthy human finger, to image blood vessels with a focus on vascularity across the interphalangeal joints. The cross-sectional images were acquired using an imager…

Photoacoustic computed tomography (PACT) is an emerging computed imaging modality that exploits optical contrast and ultrasonic detection principles to form images of the absorbed optical energy density within tissue. If the object…

Medical Physics · Physics 2017-09-08 Joemini Poudel , Thomas P. Matthews , Lei Li , Mark A. Anastasio , Lihong V. Wang

Photoacoustic imaging (PAI) can image high-resolution structures of clinical interest such as vascularity in cancerous tumor monitoring. When imaging human subjects, geometric restrictions force limited-view data retrieval causing imaging…

Image and Video Processing · Electrical Eng. & Systems 2022-04-27 Rafael Orozco , Mathias Louboutin , Felix J. Herrmann

Photoacoustic imaging (PAI) is a promising emerging imaging modality that enables spatially resolved imaging of optical tissue properties up to several centimeters deep in tissue, creating the potential for numerous exciting clinical…

Medical Physics · Physics 2021-04-15 Janek Gröhl , Melanie Schellenberg , Kris Dreher , Lena Maier-Hein

Photoacoustic tomography (PAT) and thermoacoustic tomography (TAT) both leverage acoustic signals generated by electromagnetic absorption to noninvasively image deep tissues. PAT operates by detecting optical absorption, whereas TAT targets…

Optics · Physics 2026-03-09 Skyler P. Selvin , XuanHao Wang , Handi Deng , Bohua Chen , Cheng Ma

Imaging of teeth is very important to doctors in the diagnosis and treatment of dental diseases. The main imaging modality currently used is Cone-Beam Computed Tomography (CBCT), which however suffers from ionizing radiation causing…

Medical Physics · Physics 2023-04-13 Yuting Shen , Yiyun Wang , Chengxiao Liu , Niansong Ye , Feng Gao , Lunguo Xia , Bing Fang , Fei Gao

Quantitative photoacoustic tomography (QPAT) is a recent hybrid imaging modality that couples optical tomography with ultrasound imaging to achieve high resolution imaging of optical properties of scattering media. Image reconstruction in…

Analysis of PDEs · Mathematics 2015-09-02 Tian Ding , Kui Ren , Sarah Vallelian

Fluorescence photoacoustic tomography (fPAT) is a molecular imaging modality that combines photoacoustic tomography (PAT) with fluorescence imaging to obtain high-resolution imaging of fluorescence distributions inside heterogeneous media.…

Analysis of PDEs · Mathematics 2019-09-27 Kui Ren , Rongting Zhang , Yimin Zhong

Photoacoustic computed tomography (PACT) is a non-invasive imaging modality, similar to ultrasound, with wide-ranging medical applications. Conventional PACT images are degraded by wavefront distortion caused by the heterogeneous speed of…

Image and Video Processing · Electrical Eng. & Systems 2025-08-05 Tianao Li , Manxiu Cui , Cheng Ma , Emma Alexander

Multispectral photoacoustic imaging (PAI) is an emerging imaging modality which enables the recovery of functional tissue parameters such as blood oxygenation. However, the underlying inverse problems are potentially ill-posed, meaning that…

Photoacoustic (PA) image reconstruction involves acoustic inversion that necessitates the specification of the speed of sound (SoS) within the medium of propagation. Due to the lack of information on the spatial distribution of the SoS…

Image and Video Processing · Electrical Eng. & Systems 2024-06-05 Mengjie Shi , Tom Vercauteren , Wenfeng Xia

Photoacoustic imaging has emerged in the past decades. Compared with the traditional medical imaging mode, it has better imaging performance and has great development potential in the field of biological imaging. In traditional…

Medical Physics · Physics 2020-09-03 Xianlin Song , Jianshuang Wei , Jianmin Xiong , Lingfang Song

Standard photoacoustic tomography (PAT) provides data that consist of time-dependent signals governed by the wave equation, which are measured on an observation surface. In contrast, the measured data from the recently invented full-field…

Numerical Analysis · Mathematics 2024-06-10 Ngoc Do , Markus Haltmeier , Richard Kowar , Linh V. Nguyen , Robert Nuster

Non-invasive imaging of deep blood vessels for mapping hemodynamics remains an open quest in biomedical optical imaging. Although pure optical imaging techniques offer rich optical contrast of blood and have been reported to measure blood…

Medical Physics · Physics 2022-09-20 Yang Zhang , Joshua Olick-Gibson , Anjul Khadria , Lihong V. Wang

Accurate characterization of in utero human brain maturation is critical as it involves complex and interconnected structural and functional processes that may influence health later in life. Magnetic resonance imaging is a powerful tool to…

High-quality imaging in photoacoustic computed tomography (PACT) usually requires a high-channel count system for dense spatial sampling around the object to avoid aliasing-related artefacts. To reduce system complexity, various image…

Image and Video Processing · Electrical Eng. & Systems 2024-09-24 Bowei Yao , Shilong Cui , Haizhao Dai , Qing Wu , Youshen Xiao , Fei Gao , Jingyi Yu , Yuyao Zhang , Xiran Cai

Acoustic impedance mismatches between soft tissues and bones are known to result in strong aberrations in optoacoustic and ultrasound images. Of particular importance are the severe distortions introduced by the human skull, impeding…

Medical Physics · Physics 2021-08-10 Xose Luis Dean-Ben , Daniel Razansky
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