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The relationship between epidemiology, mathematical modeling and computational tools allows to build and test theories on the development and battling of a disease. This PhD thesis is motivated by the study of epidemiological models applied…
Regularization has become a primary tool for developing reliable estimators of the covariance matrix in high-dimensional settings. To curb the curse of dimensionality, numerous methods assume that the population covariance (or inverse…
Reproduction numbers are widely used for the estimation and prediction of epidemic spreading processes over networks. However, reproduction numbers do not enable estimation and prediction in individual communities within networks, and they…
Machine learning algorithms in high-dimensional settings are highly susceptible to the influence of even a small fraction of structured outliers, making robust optimization techniques essential. In particular, within the…
A class of multiple-timescale asymptotic solutions to the equations of the susceptible-infected-recovered (SIR) model is presented for the case of high basic reproduction number, with the inverse of the latter employed as the expansion…
We consider a minimization problem whose objective function is the sum of a fidelity term, not necessarily convex, and a regularization term defined by a positive regularization parameter $\lambda$ multiple of the $\ell_0$ norm composed…
We propose two SIR models which incorporate sociological behavior of groups of individuals. It is these differences in behaviors which impose different infection rates on the individual susceptible populations, rather than biological…
We investigate the global dynamics of a general Kermack-McKendrick-type epidemic model formulated in terms of a system of renewal equations. Specifically, we consider a renewal model for which both the force of infection and the infected…
It is essential to understand the dynamics of epidemics in the presence of coexisting pathogens. There are various phenomenon that can effect the dynamics. In this paper, we formulate a mathematical model using different assumptions to…
During the COVID-19 pandemic, different countries, regions, and communities constructed various epidemic models to evaluate spreading behaviors and assist in making mitigation policies. Model uncertainties, introduced by complex…
Regularization is a central tool for addressing ill-posedness in inverse problems and statistical estimation, with the choice of a suitable penalty often determining the reliability and interpretability of downstream solutions. While recent…
The current survey paper concerns stochastic mathematical models for the spread of infectious diseases. It starts with the simplest setting of a homogeneous population in which a transmittable disease spreads during a short outbreak.…
This article introduces epidemia, an R package for Bayesian, regression-oriented modeling of infectious diseases. The implemented models define a likelihood for all observed data while also explicitly modeling transmission dynamics: an…
Variable selection is a fundamental task in statistical data analysis. Sparsity-inducing regularization methods are a popular class of methods that simultaneously perform variable selection and model estimation. The central problem is a…
The recent outbreak of a novel coronavirus (2019-nCoV) has quickly evolved into a global health crisis. The transmission potential of 2019-nCoV has been modelled and studied in several recent research works. The key factors such as the…
This paper is concerned with a nonlocal dispersal susceptible-infected-susceptible (SIS) epidemic model with Dirichlet boundary condition, where the rates of disease transmission and recovery are assumed to be spatially heterogeneous. We…
Probabilistic control design is founded on the principle that a rational agent attempts to match modelled with an arbitrary desired closed-loop system trajectory density. The framework was originally proposed as a tractable alternative to…
This work presents a model combining the simplest communicable and non-communicable disease models. The latter is, by far, the leading cause of sickness and death in the World, and introduces basal heterogeneity in populations where…
Epidemic models are always simplifications of real world epidemics. Which real world features to include, and which simplifications to make, depend both on the disease of interest and on the purpose of the modelling. In the present paper we…
Rabies remains a pressing global public health issue, demanding effective modeling and control strategies. This study focused on developing a mathematical model using ordinary differential equations (ODEs) to estimate parameters and assess…