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Proton beam therapy has been developed to irradiate the tumor with higher precision and dose conformity compared to conventional X-ray irradiation. The dose conformity of this treatment modality may be further improved if narrower proton…

Prompt Gamma Timing (PGT) is a promising technique for in vivo range verification in particle therapy, exploiting the time-of-flight between primary particles and prompt gamma rays emitted by nuclear interactions. PGT distribution is highly…

In this study, we introduce a Compton SPECT system for whole-body imaging of Actinium-225 (225Ac), one of the trending radionuclides for targeted alpha therapy (TAT). The Compton SPECT system enables multi-energy gamma photon detection with…

Medical Physics · Physics 2025-06-23 Yuemeng Feng , Arkadiusz Sitek , Shadi Abdar Esfahani , Hamid Sabet

The question of whether or not neutron therapy works has been answered. It is a qualified yes, as is the case with all of radiation therapy. But, neutron therapy has not kept pace with the rest of radiation therapy in terms of beam delivery…

Medical Physics · Physics 2014-09-09 Thomas K. Kroc , James S. Welsh

We are currently conceiving, through (MC) simulation, a multi-channel gamma detector array (TIARA for Time-of-flight Imaging ARrAy) for the online monitoring of protontherapy treatments. By measuring the Time-Of-Flight (TOF) between a beam…

Gamma-rays provide a powerful insight into the non-thermal universe and perhaps a unique probe for new physics beyond the standard model. Current experiments are already giving results in the physics of acceleration of cosmic rays in…

Instrumentation and Methods for Astrophysics · Physics 2019-08-14 Michele Doro

A major part of cosmic rays consists of the primary protons, and this portion plays a crucial role in the space applications such as shielding of spacecrafts. In this study, the proton flux values measured at the top of the atmosphere…

Instrumentation and Detectors · Physics 2025-01-03 A. Ilker Topuz

Background: Proton arc therapy is an emerging radiation therapy technique where either the gantry or the patient continuously rotates during the irradiation treatment. One of the perceived advantages of proton arc therapy is the reduced…

Medical Physics · Physics 2023-10-20 Viktor Wase , Otte Marthin , Albin Fredriksson , Anton Finnson

The development and construction of the Cherenkov Telescope Array (CTA) opens up new opportunities for the study of very high energy (VHE, E>100 GeV) sources. As a part of CTA, the ASTRI project, led by INAF, has one of the main goals to…

High Energy Astrophysical Phenomena · Physics 2017-08-09 A. Burtovoi , L. Zampieri , A. Giuliani , C. Bigongiari , F. Di Pierro , A. Stamerra , the ASTRI Collaboration , the CTA Consortium

Purpose: The purpose of this work was to provide a flexible platform for FLASH research with protons by adapting a former clinical pencil beam scanning gantry to irradiations with ultrahigh dose rates. Methods: PSI Gantry 1 treated patients…

Particle physics simulations are the cornerstone of nuclear engineering applications. Among them radiotherapy (RT) is crucial for society, with 50% of cancer patients receiving radiation treatments. For the most precise targeting of tumors,…

Machine Learning · Computer Science 2021-09-10 Oscar Pastor-Serrano , Zoltán Perkó

The radiotherapy of malignant diseases has reached much progress during the past decade. Thus, intensity modulated radiation therapy (IMRT) and VMAT (Rapidarc) now belong to the standard modalities of tumor treatment with high energy…

Medical Physics · Physics 2016-11-15 W. Ulmer , A. Carabe-Fernandez

Proton therapy exploits the finite range of charged particles in tissue to achieve dose distributions no photon based modality can replicate. Yet the modality reaches fewer than 1 percent of patients who might benefit a gap rooted in cost…

Medical Physics · Physics 2026-04-28 Vivek Maradia , Martin Bues

Proton radiotherapy promises accurate dose delivery to a tumor and minimal dose deposition to all other tissues. However, in practice the planned dose distribution may not conform to the actual one due to noisy data and different types of…

Medical Physics · Physics 2018-09-07 Jaroslav Albert , Rudi Labarbe , Edmond Sterpin

SOlar Neutron TRACking (SONTRAC) is a detector concept based on a bundle of plastic scintillators by aiming at tracking the solar neutrons through the generation of the secondary particles such as protons from the (n, np) and (n, p)…

Instrumentation and Detectors · Physics 2024-12-04 Ahmet Ilker Topuz

The WFIRST-AFTA 2.4 m telescope will provide in the next decade the opportunity to host a coronagraph for the imaging and spectroscopy of planets and disks. The telescope, however, is not ideal, given its obscured aperture. Only recently…

Instrumentation and Methods for Astrophysics · Physics 2015-09-18 John Krist , Bijan Nemati , Bertrand Mennesson

Charged particle therapy (CPT) is an advanced modality of radiation therapy which has grown rapidly worldwide, driven by recent developments in technology and methods of delivery. To ensure safe and high quality treatments, various…

Instrumentation and Detectors · Physics 2021-11-16 J. S. L. Yap , N. J. S. Bal , A. Kacperek , J. Resta López , C. P. Welsch

Boron Neutron Capture Therapy (BNCT) is a form of radiotherapy based on the irradiation of the tumour with a low energy neutron beam, after the administration of a selective drug enriched in boron-10. The therapy exploits the high cross…

We present a full-scale clinical prototype system for in vivo range verification of proton pencil-beams using the prompt gamma-ray spectroscopy method. The detection system consists of eight LaBr3 scintillators and a tungsten collimator,…

Hadron therapy is a novel treatment against cancer. The main advantage of this therapy causes less side effect in comparison to X-ray irradiation methods. Hadron therapy is just ahead of a significant breakthrough since this technique can…

Instrumentation and Detectors · Physics 2020-05-07 Ákos Sudár
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