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Hydrophobic interactions are central to biological self-assembly and soft matter organization, yet their microscopic origins remain debated. A key hallmark is the strengthening of attraction between hydrophobic solutes with increasing…

Soft Condensed Matter · Physics 2025-09-25 Nigel B. Wilding , Francesco Turci

We use molecular simulations to demonstrate the connection between transverse water-water correlations and wetting phenomena for a range of hydrophobic to hydrophilic solid surfaces.Near superhydrophobic surfaces, the correlations are long…

Soft Condensed Matter · Physics 2014-09-10 Rahul Godawat , Sumanth N. Jamadagni , Vasudevan Venkateshwaran , Shekhar Garde

Hydrophobic interactions have been studied in detail in the past based on hydrophobic polymers, such as polystyrene (PS). Because fluorinated materials have relatively low surface energy, they often show both oleophobicity and…

Soft Condensed Matter · Physics 2022-02-08 Weishuai Di , Xin Wang , Yanyan Zhou , Yuehai Mei , Wei Wang , Yi Cao

Molecular dynamics simulations have revealed a dramatic increase, with increasing temperature, of the amplitude of electrostatic fluctuations caused by water at the active site of metalloprotein plastocyanin. The increased breadth of…

Biological Physics · Physics 2009-11-13 David N. LeBard , Dmitry V. Matyushov

This paper reviews the molecular theory of hydrophobic effects relevant to biomolecular structure and assembly in aqueous solution. Recent progress has resulted in simple, validated molecular statistical thermodynamic theories and…

Chemical Physics · Physics 2015-06-26 Lawrence R. Pratt

A comprehensive, semi-quantitative model for the thermodynamics of hydrophobic solvation is presented. The model is based on a very simple premise suggested by the scaled particle theory and treats both solute and solvent molecules as hard…

Biological Physics · Physics 2007-05-23 Hong Qian

Is there a low-density region ('gap') between water and a hydrophobic surface? Previous X-ray/neutron reflectivity results have been inconsistent because the effect (if any) is sub-resolution for the surfaces studied. We have used X-ray…

While individual water molecules adsorb strongly on a talc surface (hydrophilic behavior), a droplet of water beads up on the same surface (hydrophobic behavior). To rationalize this dichotomy, we investigate the influence of the…

Chemical Physics · Physics 2011-09-21 Benjamin Rotenberg , Amish J. Patel , David Chandler

Employing smart Monte Carlo sampling techniques within the grand canonical ensemble, we investigate the properties of water at a model hydrophobic substrate. By reducing the strength of substrate-water attraction we find that fluctuations…

Statistical Mechanics · Physics 2015-07-08 Robert Evans , Nigel B. Wilding

To comprehend the complexities of the ice-water interface, we perform a study that attempts to correlate the altered dynamics of water to its perturbed structure at, and due to, the interface. The deviation from bulk values of structural…

Soft Condensed Matter · Physics 2019-08-02 Saumyak Mukherjee , Sayantan Mondal , Biman Bagchi

Hydration of hydrophobic solutes in water is the cause of different phenomena, including the hydrophobic heat-capacity anomaly, which are not yet fully understood. Because of its topicality, there has recently been growing interest in the…

Soft Condensed Matter · Physics 2009-11-10 Susanne Moelbert , Paolo De Los Rios

Thermodynamics tells us to expect underwater contact between two hydrophobic surfaces to result in stronger adhesion compared to two hydrophilic surfaces. However, presence of water changes not only energetics, but also the dynamic process…

Soft Condensed Matter · Physics 2022-11-22 Mengyue Sun1 , Nityanshu Kumar1 , Ali Dhinojwala , Hunter King

We present an overview of the recent progress that has been made in understanding the origin of hydrophobic interactions. We discuss the different character of the solvation behavior of apolar solutes at small and large length scales. We…

Soft Condensed Matter · Physics 2009-11-07 Pieter Rein ten Wolde

Clarifying the factors that control the contact angle of a liquid on a solid substrate is a long-standing scientific problem pertinent across physics, chemistry and materials science. Progress has been hampered by the lack of a…

Statistical Mechanics · Physics 2019-11-11 Robert Evans , Maria C. Stewart , Nigel B. Wilding

The solvation of charged, nanometer-sized spherical solutes in water, and the effective, solvent-induced force between two such solutes are investigated by constant temperature and pressure Molecular Dynamics simulations of model solutes…

Soft Condensed Matter · Physics 2009-11-10 J. Dzubiella , J. -P. Hansen

The hydrophobic effect stabilizes the native structure of proteins by minimizing the unfavourable interactions between hydrophobic residues and water through the formation of a hydrophobic core. Here we include the entropic and enthalpic…

Soft Condensed Matter · Physics 2016-03-23 Erik van Dijk , Patrick Varilly , Tuomas Knowles , Daan Frenkel , Sanne Abeln

An accurate description of the structure and dynamics of interfacial water is essential for phospholipid membranes, since it determines their function and their interaction with other molecules. Here we consider water confined in stacked…

Soft Condensed Matter · Physics 2018-11-16 Sotiris Samatas , Carles Calero , Fausto Martelli , Giancarlo Franzese

The properties of liquid water are known to change drastically in confined geometries. A most interesting and intriguing phenomenon is that the diffusion of water is found to be strongly enhanced by the proximity of a hydrophobic confining…

Soft Condensed Matter · Physics 2024-12-06 Lorenzo Agosta , Kersti Hermansson , Mikhail Dzugutov

We investigate the curvature-dependence of water dynamics in the vicinity of hydrophobic spherical solutes using molecular dynamics simulations. For both, the lateral and perpendicular diffusivity as well as for H-bond kinetics of water in…

Soft Condensed Matter · Physics 2016-01-22 R. Gregor Weiß , Matthias Heyden , Joachim Dzubiella

We use appropriately defined short ranged reference models of liquid water to clarify the different roles local hydrogen bonding, van der Waals attractions, and long ranged electrostatic interactions play in the solvation and association of…

Statistical Mechanics · Physics 2015-02-20 Richard C. Remsing , John D. Weeks